1'-乙酰氧基胡椒酚乙酸酯

1'-Acetoxychavicol acetate

	产品编号	CFN70397
	CAS编号	52946-22-2
	分子式 = 分子量	C₁₃H₁₄O₄ = 234.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The rhizomes of Alpinia galanga
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
1'-乙酰氧基胡椒酚乙酸酯	CFN70397	52946-22-2	1mg	QQ客服：215959384
1'-乙酰氧基胡椒酚乙酸酯	CFN70397	52946-22-2	5mg	QQ客服：215959384
1'-乙酰氧基胡椒酚乙酸酯	CFN70397	52946-22-2	10mg	QQ客服：215959384
1'-乙酰氧基胡椒酚乙酸酯	CFN70397	52946-22-2	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Chang Gung University (Taiwan)

Seoul National University of Science and Technology (Korea)

Sapienza University of Rome (Italy)

Kyushu University (Japan)

University of Pretoria (South Africa)

Korea Intitute of Science and Technology (KIST) (Korea)

Copenhagen University (Denmark)

Pennsylvania State University (USA)

Universiti Kebangsaan Malaysia (Malaysia)

Universidade de Franca (Brazil)

Imperial College London (United Kingdom)

CSIRO - Agriculture Flagship (Australia)

University of the Basque Country (Spain)

University of Wisconsin-Madison (USA)

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Description:

1'-Acetoxychavicol acetate is a xanthine oxidase inhibitor, it shows potent inhibitory effects on NF-kappaB, and NO production, it induces the apoptosis of myeloma cells in vitro and in vivo, which could contribute to the anticarcinogenic properties of it. 1'-Acetoxychavicol acetate can inhibit the development of AOM-induced ACF through its suppression of cell proliferation in the colonic mucosa and it may be a possible chemopreventive agent against colon tumourigenesis.

Targets:

Xanthine oxidase | NF-κB | NO | AP-1 | Fas | NOS | Caspase | STAT1

In vitro:

Carcinogenesis, 2000, 21(12):2151-7.

Apoptosis induced by 1′-acetoxychavicol acetate in Ehrlich ascites tumor cells is associated with modulation of polyamine metabolism and caspase-3 activation.[Reference: WebLink]

The efficacy of the antitumor activity of 1′-acetoxychavicol acetate (ACA), reported to be a suppressor of chemically induced carcinogenesis, was evaluated in Ehrlich ascites tumor cells.
METHODS AND RESULTS:
ACA treatment resulted in changes in morphology and a dose-dependent suppression of cell viability. Apoptosis, characterized by nuclear condensation, membrane blebbing, cell shrinkage and a significant induction of caspase-3-like protease activity at 8 h in a time-course study were observed. Formation of apoptotic bodies was preceded by lowering of intracellular polyamines, particularly putrescine, and both dose- and time-dependent inhibitory and activation effect by ACA on ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SSAT), respectively. Administration of exogenous polyamines prevented ACA-induced apoptosis represented by a reduction in the number of apoptotic bodies and also caused reduction in the induced caspase-3-like protease activity at 8 h.
CONCLUSIONS:
These findings suggest that the anticarcinogenic effects of ACA might be partly due to perturbation of the polyamine metabolic pathway and triggering of caspase-3-like activity, which result in apoptosis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Orobanchyl acetate; Orobanchyl acetate	CFN89504	1413843-71-6	C₂₁H₂₄O₇ = 388.41	5mg	QQ客服：3257982914
茵芋碱; Skimmianin	CFN92555	83-95-4	C₁₄H₁₃NO₄ = 259.3	20mg	QQ客服：1457312923
银松素; Pinosylvin	CFN98203	22139-77-1	C₁₄H₁₂O₂ = 212.3	20mg	QQ客服：1413575084
2,3'-二甲基三羟苯丙酮 ; 2-Methyl-4-isobutyrylphloroglucinol	CFN96869	69480-03-1	C₁₁H₁₄O₄ = 210.22	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.268 mL	21.3402 mL	42.6803 mL	85.3606 mL	106.7008 mL
5 mM	0.8536 mL	4.268 mL	8.5361 mL	17.0721 mL	21.3402 mL
10 mM	0.4268 mL	2.134 mL	4.268 mL	8.5361 mL	10.6701 mL
50 mM	0.0854 mL	0.4268 mL	0.8536 mL	1.7072 mL	2.134 mL
100 mM	0.0427 mL	0.2134 mL	0.4268 mL	0.8536 mL	1.067 mL