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  • 汉黄芩苷

    Wogonoside

    汉黄芩苷
    产品编号 CFN99710
    CAS编号 51059-44-0
    分子式 = 分子量 C22H20O11 = 460.39
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Scutellaria baicalensis Georgi.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    汉黄芩苷 CFN99710 51059-44-0 10mg QQ客服:2932563308
    汉黄芩苷 CFN99710 51059-44-0 20mg QQ客服:2932563308
    汉黄芩苷 CFN99710 51059-44-0 50mg QQ客服:2932563308
    汉黄芩苷 CFN99710 51059-44-0 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Helmholtz Zentrum München (Germany)
  • University of Hawaii Cancer Center (USA)
  • Florida A&M University (USA)
  • Weizmann Institute of Science (Israel)
  • Technical University of Denmark (Denmark)
  • Deutsches Krebsforschungszentrum (Germany)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Auburn University (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Osmania University (India)
  • University of Leipzig (Germany)
  • University of Vienna (Austria)
  • Hamdard University (India)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(11):14105-21
  • Scientific World Journal.2014, 2014:654193
  • Molecules.2015, 20(11):20014-30
  • University of Limpopo2016, 1-237
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Chem Biol Interact.2016, 258:59-68
  • Bulletin of Health Research2016, 44(4):279-286
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Semyung University2017, 149407
  • Nat Prod Commun.2018, 10.1177
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • J Cell Biochem.2018, 119(2):2231-2239
  • Microchemical Journal2018, 137:168-173
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • Korean J. Crop Sci.2018, 63(2):131-139
  • J Nat Med.2018, 72(3):734-744
  • Front Neurosci.2019, 13:1091
  • Int J Mol Sci.2019, 20(21):E5488
  • Chemistry of Plant Materials.2019, 215-222
  • Molecules.2019, 24(22):E4022
  • Ann Transl Med.2019, 7(23):731
  • Food Chem Toxicol.2020, 135:110863
  • Antioxidants (Basel).2020, 9(2):E120
  • ...
  • 生物活性
    Description: Wogonoside has anticoagulant, anti-inflammatory, anti-angiogenic and anticancer effects, it may exert its anti-inflammatory effect via dual inhibition of NF-κB and NLRP3 inflammasome. Wogonoside induced autophagy through the MAPK-mTOR pathway, it inhibited LTB 4 production at the concentration of 100 uM.
    Targets: IL Receptor | NF-kB | NOS | TLR | p38MAPK | JNK | ERK | p21 | TNF-α | p65 | IkB | mTOR | Histamine Receptor | IKK
    In vitro:
    Toxicology. 2009 May 2;259(1-2):10-7.
    Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction.[Pubmed: 19428938 ]
    Wogonoside, one flavonoid derived from the root of Scutellaria baicalensis Georgi, has been reported for its anti-inflammation activity; however, whether it can inhibit inflammation-induced angiogenesis is still unclear.
    METHODS AND RESULTS:
    In the present study, we evaluated the effect of wogonoside on lipopolysaccharide (LPS)-induced angiogenesis in vitro and in vivo. Wogonoside suppressed the LPS-stimulated migration and tube formation of human umbilical vein endothelial cells (HUVECs), as well as microvessel sprouting from rat aortic rings in vitro. Moreover, wogonoside also inhibited LPS-stimulated vessel growth of Chicken chorioallantoic membrane (CAM) in vivo. The mechanism revealed that wogonoside inhibited LPS-induced toll-like receptor 4 (TLR4) up-regulation and its downstream mitogen-activated protein kinases (MAPKs) activation, by decreasing the phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase.
    CONCLUSIONS:
    The results suggest that wogonoside inhibits LPS-induced angiogenesis both in vitro and in vivo, and that it might have a therapeutic potential for the diseases associated with the development of both inflammation and angiogenesis progress.
    Food Chem Toxicol. 2013 Jan;51:53-60.
    Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway.[Pubmed: 23000445 ]
    Previous studies have demonstrated that wogonoside, a bioactive flavonoid extracted from the root of Scutellaria baicalensis Gerogi, has anti-inflammatory and anti-angiogenic activities.
    METHODS AND RESULTS:
    In this study, we evaluated wogonoside-induced autophagy on human breast MDA-MB-231 cells. We report that wogonoside triggered the formation of microtubule-associated protein-light chain 3 (MAP-LC3) positive autophagosomes and the accumulation of acidic vesicular and autolysosomes in MDA-MB-231 cells. In addition, cells treated by wogonoside developed autophagosome-like characteristics, including single and double membrane vacuoles containing intact and degraded cellular debris. The results showed that wogonoside promotes the expression of LC3-II and Beclin-1. Furthermore, wogonoside inhibited cell growth of MDA-MB-231 cells in a concentration- and time-dependent manner, which was associated with wogonoside-induced autophagy. Wogonoside also suppressed the activation of mammalian target of rapamycin (mTOR) and p70-S6 kinase (p70S6K) by regulating the expression of the extracellular signal-regulated kinase (ERK1/2) and p38 involved mitogen-activated protein kinase (MAPK) signaling pathway.
    CONCLUSIONS:
    Taken together, these results suggest that wogonoside partially inhibits MDA-MB-231 cell growth by inducing autophagy through the MAPK-mTOR pathway and may be a promising anti-tumor agent.
    In vivo:
    Biochem Pharmacol. 2015 Mar 15;94(2):142-54.
    Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation.[Pubmed: 25677765]
    Previous studies have demonstrated that wogonoside, the glucuronide metabolite of wogonin, has anti-inflammatory, anti-angiogenic and anticancer effects. However, the anti-inflammatory mechanism of wogonoside has not been fully elucidated. Recently, NLRP3 inflammasome has been reported to be correlated with inflammatory bowel disease for its ability to induce IL-1β release. Nevertheless, there are few drug candidates targeting NLRP3 inflammasome for this disease.
    METHODS AND RESULTS:
    In this study, we investigated the anti-inflammatory effect of wogonoside in dextran sulfate sodium (DSS)-induced murine colitis and further revealed the underlying mechanisms by targeting NF-κB and NLRP3 inflammasome. Wogonoside treatment dose-dependently attenuated DSS-induced body weight loss and colon length shortening. Moreover, wogonoside prevented DSS-induced colonic pathological damage, remarkably inhibited inflammatory cells infiltration and significantly decreased myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) activities. The production of pro-inflammatory mediators in serum and colon was also significantly reduced by wogonoside. The underlying mechanisms for the protective effect of wogonoside in DSS-induced colitis may be attributed to its inhibition on NF-κB and NLRP3 inflammasome activation in colons. Furthermore, wogonoside markedly decreased production of IL-1β, TNF-α and IL-6 and suppressed mRNA expression of pro-IL-1β and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-κB and NLRP3 inflammasome.
    CONCLUSIONS:
    In conclusion, our study demonstrated that wogonoside may exert its anti-inflammatory effect via dual inhibition of NF-κB and NLRP3 inflammasome, suggesting that wogonoside might be a potential effective drug for inflammatory bowel diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1721 mL 10.8604 mL 21.7207 mL 43.4414 mL 54.3018 mL
    5 mM 0.4344 mL 2.1721 mL 4.3441 mL 8.6883 mL 10.8604 mL
    10 mM 0.2172 mL 1.086 mL 2.1721 mL 4.3441 mL 5.4302 mL
    50 mM 0.0434 mL 0.2172 mL 0.4344 mL 0.8688 mL 1.086 mL
    100 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.4344 mL 0.543 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    千层纸素A-7-0-β-D-葡萄糖醛酸苷; Oroxylin A 7-O-beta-D-glucuronide CFN90191 36948-76-2 C22H20O11 = 460.39 20mg QQ客服:1148253675
    千层纸素A-7-0-β-D-葡萄糖醛酸苷甲酯; Oroxylin A 7-O-beta-D-glucuronide methyl ester CFN92282 82475-01-2 C23H22O11 = 474.4 5mg QQ客服:2932563308
    Glychionide A; Glychionide A CFN92280 119152-50-0 C21H18O11 = 446.4 5mg QQ客服:215959384
    汉黄芩苷; Wogonoside CFN99710 51059-44-0 C22H20O11 = 460.39 20mg QQ客服:2932563308
    穿心莲黄酮苷C; Andrographidine C CFN97852 113963-39-6 C23H24O10 = 460.44 5mg QQ客服:3257982914
    5-Hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside; 5-Hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside CFN95209 942626-74-6 C23H26O10 = 462.5 10mg QQ客服:2932563308
    穿心莲黄酮苷A; Andrographidine A CFN95210 113963-37-4 C23H26O10 = 462.5 5mg QQ客服:215959384
    白杨素-7-O-龙胆二糖苷; Chrysin 7-O-beta-gentiobioside CFN90833 88640-89-5 C27H30O14 = 578.5 10mg QQ客服:1413575084
    木蝴蝶苷A; Oroxin A CFN99712 57396-78-8 C21H20O10 = 432.38 20mg QQ客服:215959384
    黄芩苷; Baicalin CFN99111 21967-41-9 C21H18O11 = 446.37 20mg QQ客服:1413575084

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