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  • 木蝴蝶苷A

    Oroxin A

    木蝴蝶苷A
    产品编号 CFN99712
    CAS编号 57396-78-8
    分子式 = 分子量 C21H20O10 = 432.38
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria baicalensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    木蝴蝶苷A CFN99712 57396-78-8 10mg QQ客服:2056216494
    木蝴蝶苷A CFN99712 57396-78-8 20mg QQ客服:2056216494
    木蝴蝶苷A CFN99712 57396-78-8 50mg QQ客服:2056216494
    木蝴蝶苷A CFN99712 57396-78-8 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Copenhagen University (Denmark)
  • National Cancer Institute (USA)
  • University of Cincinnati (USA)
  • University of Lodz (Poland)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • University of Beira Interior (Portugal)
  • University of Melbourne (Australia)
  • Universidade do Porto (Portugal)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Max-Planck-Insitut (Germany)
  • Universidad de Antioquia (Colombia)
  • University of Toronto (Canada)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • S.N.D.T. Women's University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Microb Pathog.2019, 131:128-134
  • Phytochem Anal.2016, 27(5):296-303
  • Evid-Based Compl Alt2020, 7202519:13
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Processes 2021, 9(5),894.
  • Food Funct.2021, 12(13):5892-5902.
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Indian J Pharm Sci.2022, 84(3):144-151
  • Chem Biol Interact.2019, 298:1-7
  • Life Sci.2022, 311(Pt A):121157.
  • Molecules.2021, 26(9):2526.
  • Microchemical Journal2022, 182: 107874.
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Nutrients2020, 12(3):811.
  • J.Food Processing & Preservation2022, jfpp.16666
  • Int J Mol Sci.2017, 18(5)
  • Industrial Crops and Products2022, 188:115638
  • Int J Mol Sci.2022, 23(21):13112.
  • J Cell Mol Med . 2023, jcmm.17954.
  • Molecules.2019, 24(6):E1155
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • Molecules.2019, 24(4):E709
  • Tissue Cell.2022, 78:101901.
  • ...
  • 生物活性
    Description: Oroxin A is a xanthine oxidase (XO) inhibitor, it exerts its antibreast cancer effects by inducing ER stress-mediated senescence, activating the key stress signaling pathway, and increasing key ER stress genes and expression levels.
    Targets: XO
    In vitro:
    Anticancer Drugs. 2016 Mar;27(3):204-15.
    Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence.[Pubmed: 26599214 ]
    Breast cancer is a major cause of cancer death among women. Although various anticancer drugs have been used in clinics, drugs that are effective against advanced and metastatic breast cancer are still lacking and in great demand.
    METHODS AND RESULTS:
    In this study, we found that Oroxin A, an active component isolated from the herb Oroxylum indicum (L.) Kurz, effectively inhibited the growth of human breast cancer cells MDA-MB-231 and MCF7 by inducing endoplasmic reticulum (ER) stress-mediated senescence. Oroxin A caused breast cancer cell cycle arrest at the G2/M stage, and reorganization of microtubules and actin cytoskeleton accompanied by a decrease in cellular mitosis. ER-specific probe ER-Tracker Red and confocal microscope imaging showed that ER-Tracker Red-positive cells increased in an Oroxin A dosage-dependent manner. In addition, Oroxin A increased cell population with high β-Gal activity and SAHF-positive staining; these data suggest that Oroxin A induces breast cancer cell ER stress and senescence. Mechanistic studies showed that Oroxin A led to a significant increase in intracellular reactive oxygen species levels, promoted expression of ER stress markers ATF4 and GRP78, and increased the phosphorylation of a key stress-response signaling protein p38, resulting in an ER stress-mediated senescence.
    CONCLUSIONS:
    Taken together, our data indicate that Oroxin A exerts its antibreast cancer effects by inducing ER stress-mediated senescence, activating the key stress p38 signaling pathway, and increasing key ER stress genes ATF4 and GRP78 expression levels.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3128 mL 11.5639 mL 23.1278 mL 46.2556 mL 57.8195 mL
    5 mM 0.4626 mL 2.3128 mL 4.6256 mL 9.2511 mL 11.5639 mL
    10 mM 0.2313 mL 1.1564 mL 2.3128 mL 4.6256 mL 5.782 mL
    50 mM 0.0463 mL 0.2313 mL 0.4626 mL 0.9251 mL 1.1564 mL
    100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.4626 mL 0.5782 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    白杨素-7-O-龙胆二糖苷; Chrysin 7-O-beta-gentiobioside CFN90833 88640-89-5 C27H30O14 = 578.5 5mg QQ客服:1413575084
    木蝴蝶苷A; Oroxin A CFN99712 57396-78-8 C21H20O10 = 432.38 20mg QQ客服:2159513211
    黄芩苷; Baicalin CFN99111 21967-41-9 C21H18O11 = 446.37 20mg QQ客服:1413575084
    黄芩苷甲酯; Baicalin methyl ester CFN92283 82475-03-4 C22H20O11 = 460.4 20mg QQ客服:1457312923
    黄芩素 7-O-beta-D-葡萄糖醛酸乙酯; Baicalein 7-O-beta-D-ethylglucuronide CFN91993 675624-38-1 C23H22O11 = 474.41 5mg QQ客服:2159513211
    黄芩素 6-O-葡萄糖苷; Baicalein 6-O-glucoside CFN92361 28279-72-3 C21H20O10 = 432.4 5mg QQ客服:3257982914
    木蝴蝶苷B; Oroxin B CFN99713 114482-86-9 C27H30O15 = 594.52 20mg QQ客服:215959384
    千层纸素A-7-0-β-D-葡萄糖醛酸苷; Oroxylin A 7-O-beta-D-glucuronide CFN90191 36948-76-2 C22H20O11 = 460.39 20mg QQ客服:1457312923
    千层纸素A-7-0-β-D-葡萄糖醛酸苷甲酯; Oroxylin A 7-O-beta-D-glucuronide methyl ester CFN92282 82475-01-2 C23H22O11 = 474.4 5mg QQ客服:1457312923
    Glychionide A; Glychionide A CFN92280 119152-50-0 C21H18O11 = 446.4 5mg QQ客服:1457312923

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