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    Sophoridine

    槐定碱
    产品编号 CFN97172
    CAS编号 6882-68-4
    分子式 = 分子量 C15H24N2O = 248.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Sophora flavescens Ait.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    槐定碱 CFN97172 6882-68-4 10mg QQ客服:1413575084
    槐定碱 CFN97172 6882-68-4 20mg QQ客服:1413575084
    槐定碱 CFN97172 6882-68-4 50mg QQ客服:1413575084
    槐定碱 CFN97172 6882-68-4 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(11):14105-21
  • Mol Med Rep.2014, 9(5):1653-9
  • Mol Med Rep.2015, 12(5):7789-95
  • Int J Mol Sci.2015, 16(1):1232-51
  • Acta Physiologiae Plantarum2016, 38:7
  • Sci Rep. 2017, 12953(7)
  • J Ethnopharmacol.2017, 198:205-213
  • Universite de Bordeaux2017, 2017BORD0867
  • J Nat Med.2017, 71(2):380-388
  • Arch Toxicol.2017, 91(10):3225-3245
  • Sci Rep. 2018, 10590
  • Nat Prod Sci.2018, 24(3):206
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Front Immunol.2018, 9:2091
  • Journal of Life Science2018, 917-922
  • Phytother Res.2019, 10.1002
  • Molecules.2019, 24(1):E159
  • Molecules.2019, 24(11):E2102
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Sci Rep.2019, 9(1):4646
  • Food Research International2020, 108987
  • J Pharmaceut Biomed2020, 178:112894
  • Biochem Biophys Res Commun.2020, 522(4):1052-1058
  • ...
  • 生物活性
    Description: Sophoridine has anti-inflammatory, anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems. Early and short-time applying sophoridine has neuroprotective effect min permanent middle cerebral artery occlusion (pMCAO) rat brain by down-regulating TRAF6 and up-regulating p-ERK1/2 expression, ameliorating brain infaction and edema. Sophoridine also possesses antiviral activities against Coxsackievirus B3, by regulating cytokine expression, may represent a potential therapeutic agent for viral myocarditis.
    Targets: TLR | TNF-α | IL Receptor | ROS | CDK | Bcl-2/Bax | Caspase | p53 | JNK | p38MAPK | AP-1 | NF-kB | ERK
    In vitro:
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 May;31(5):585-9.
    Sophoridine suppresses inflammatory cytokine secretion by lipopolysaccharide-induced RAW264.7 cells and its mechanism.[Pubmed: 25940281]
    To observe the effects of Sophoridine on lipopolysaccharide (LPS)-induced secretion of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) as well as the expressions of Toll-like receptor 4 (TLR4) and c-Jun in RAW264.7 cells and explore the molecular mechanism of anti-LPS of Sophoridine.
    METHODS AND RESULTS:
    RAW264.7 cells were cultured and divided into four groups: macrophage control group (using serum-free DMEM to incubate cells), Sophoridine control group (using 31.25 mg/L Sophoridine-added DMEM to incubate cells), LPS group and Sophoridine intervention group (using 100 μg/L LPS DMEM to incubate cells for 60 minutes, then throwing away LPS and adding serum-free DMEM or 31.25 mg/L Sophoridine DMEM to incubate cells). Cells and culture medium were collected respectively at 5, 30, 60 and 120 minutes after the above treatment. The expression levels of TLR4 and c-Jun mRNA were determined by reverse transcription PCR (RT-PCR), and the expression of c-Jun protein in RAW264.7 cells was measured by immunocytochemistry and Western blotting; The levels of TNF-α and IL-1β in cell culture medium were analyzed by ELISA. Compared with macrophage control group, Sophoridine control group had no statistical difference in each index. Compared with macrophage control group, the expressions of TLR4 mRNA, c-Jun mRNA and protein as well as the secretion of TNF-α and IL-1β significantly increased at each time point in LPS group, and maintained the level to 120 minutes. Sophoridine suppressed the expressions of TLR4 mRNA, c-Jun mRNA and protein, and reduced the secretion of TNF-α and IL-1β in LPS-stimulated RAW264.7 cells in Sophoridine intervention group.
    CONCLUSIONS:
    Sophoridine down-regulated the secretion of TNF-α and IL-1β in LPS-induced RAW264.7 cells via inhibiting the expressions of TLR4 and c-Jun.
    Zhongguo Yao Li Xue Bao. 1999 Jun;20(6):517-20.
    Anti-arrhythmic effects of sophoridine and oxysophoridine.[Pubmed: 10678144]
    To compare the effects of oxysophoridine (Oxy) and sophoridine (Sop) on experimental arrhythmias and myocardial physiologic properties.
    METHODS AND RESULTS:
    Arrhythmias were induced by drugs and myocardial ischemia. Physiologic properties were determined on isolated heart atria. Oxy 500 mg.kg-1 (1/6 LD50) decreased the incidence of ventricular arrhythmias induced by aconitine (P < 0.01), increased the threshold dose of ouabain-induced ventricular premature (VP, P < 0.05), ventricular tachycardia (VT, P < 0.05), ventricular fibrillation (VF, P < 0.01), and cardiac arrest, (P < 0.01). After i.v. Oxy 500 mg.kg-1 into the rats with ligation of left anterior descending coronary artery, the total numbers of ectopic beats were decreased (P < 0.05), the incidence of VF was lowered, and the duration of VT was shortened (P < 0.01). Oxy 250 mg.kg-1 (1/13 LD50) i.v. shortened the duration of arrhythmias induced by BaCl2 (P < 0.01) and delayed the onset of arrhythmias induced by chloroform-epinephrine (P < 0.05). Oxy produced dose-dependent positive inotropic effects in the isolated left atrial of guinea pigs, increased the concentration of epinephrine to elicit automaticity in left atria, decreased slightly the excitability, and prolonged the functional refractory period. Sop produced the similar effects on arrhythmias as Oxy.
    CONCLUSIONS:
    Oxy produced the similar anti-arrhythmic effects as Sop did at the equivalent effective dose.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0258 mL 20.1288 mL 40.2576 mL 80.5153 mL 100.6441 mL
    5 mM 0.8052 mL 4.0258 mL 8.0515 mL 16.1031 mL 20.1288 mL
    10 mM 0.4026 mL 2.0129 mL 4.0258 mL 8.0515 mL 10.0644 mL
    50 mM 0.0805 mL 0.4026 mL 0.8052 mL 1.6103 mL 2.0129 mL
    100 mM 0.0403 mL 0.2013 mL 0.4026 mL 0.8052 mL 1.0064 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    槐定碱; Allomatrine CFN90222 641-39-4 C15H24N2O = 248.36 20mg QQ客服:1413575084
    槐定碱; Sophoridine CFN97172 6882-68-4 C15H24N2O = 248.4 20mg QQ客服:3257982914
    氧化槐定碱; Oxysophoridine CFN90290 54809-74-4 C15H24N2O2 = 264.36 5mg QQ客服:2932563308
    氧化槐果碱; Oxysophocarpine CFN98321 26904-64-3 C15H22N2O2 = 262.4 20mg QQ客服:3257982914
    苦参碱; Matrine CFN98835 519-02-8 C15H24N2O = 248.4 20mg QQ客服:2932563308
    12,13-去氢苦参碱; Lemannine CFN92839 58480-54-9 C15H22N2O = 246.4 5mg QQ客服:2159513211
    新槐胺; Neosophoramine CFN98875 52932-74-8 C15H20N2O = 244.3 5mg QQ客服:2932563308
    槐果碱; Sophocarpine CFN99182 145572-44-7 C15H22N2O = 246.35 20mg QQ客服:1148253675
    氧化苦参碱; 苦参素; Oxymatrine CFN99805 16837-52-8 C15H24N2O2 = 264.4 20mg QQ客服:1148253675
    槐苦参醇,槐醇; (+)-Sophoranol CFN92840 3411-37-8 C15H24N2O2 = 264.4 5mg QQ客服:215959384

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