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  • 槐苦参醇,槐醇

    (+)-Sophoranol

    槐苦参醇,槐醇
    产品编号 CFN92840
    CAS编号 3411-37-8
    分子式 = 分子量 C15H24N2O2 = 264.4
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Alkaloids
    植物来源 The herbs of Sophora flavescens
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    槐苦参醇,槐醇 CFN92840 3411-37-8 1mg QQ客服:215959384
    槐苦参醇,槐醇 CFN92840 3411-37-8 5mg QQ客服:215959384
    槐苦参醇,槐醇 CFN92840 3411-37-8 10mg QQ客服:215959384
    槐苦参醇,槐醇 CFN92840 3411-37-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Buenos Aires (Argentina)
  • Heidelberg University (Germany)
  • Ateneo de Manila University (Philippines)
  • Seoul National University (Korea)
  • Medical University of South Carolina (USA)
  • Yale University (USA)
  • Colorado State University (USA)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
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  • Harvard University (USA)
  • University of Madras (India)
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  • University of Illinois (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:242
  • Oncotarget.2015, 6(31):30831-49
  • J Pharm Biomed Anal.2016, 129:50-59
  • J Drug Target.2016, 24:1-28
  • J Agric Food Chem.2016, 64(35):6783-90
  • Journal of Life Science2017, 233-240
  • J Biochem Mol Toxicol.2017, 31(9)
  • J Nat Med.2017, 71(4):745-756
  • Journal of Analytical Chemistry2017, 854-861
  • RSC Advances2017, 86
  • Mol Pharm.2018, 15(8):3285-3296
  • Bio-protocol2018, 9(14):e3301
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Drug Invention Today2019, 12(6):1303-1306
  • Microb Pathog.2019, 131:128-134
  • Molecules.2019, 24(12):E2286
  • Molecules.2019, 24(21):E3834
  • Molecules.2019, 24(6):E1177
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Phytomedicine.2019, 57:95-104
  • Int Immunopharmacol.2019, 71:22-31
  • Molecules.2020, 25(3):734
  • ...
  • 生物活性
    Description: (+)-Sophoranol exhibits antiviral activity against the Coxsackie virus B3. It also shows potent anti-HBV activity with an inhibitory potency against HBsAg secretion and against HBeAg secretion.
    Targets: HBV
    In vitro:
    J Nat Prod. 2015 Jul 24;78(7):1683-8.
    Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis.[Pubmed: 26132528]

    CONCLUSIONS:
    Three new matrine-type alkaloids, (+)-5α-hydroxyoxysophocarpine (1), (-)-12β-hydroxyoxysophocarpine (2), and (+)-5α-hydroxylemannine (3), along with 14 known analogues, (-)-sophocarpine (4), (-)-5α-hydroxysophocarpine (5), (-)-9α-hydroxysophocarpine (6), (+)-12α-hydroxysophocarpine (7), (-)-12β-hydroxysophocarpine (8), (+)-oxysophocarpine (9), (+)-matrine (10), (+)-Sophoranol (11), (+)-9α-hydroxymatrine (12), (-)-14β-hydroxymatrine (13), (+)-oxymatrine (14), (+)-5α-hydroxyoxymatrine (15), (-)-14β-hydroxyoxymatrine (16), and (+)-sophoramine (17), were isolated from the rhizomes of Sophora tonkinensis. Their structures were elucidated via spectrometric data analyses, and the absolute configurations were established by single-crystal X-ray diffraction and ECD data.
    CONCLUSIONS:
    Alkaloids 2, 6, 11, and 13 exhibited antiviral activity against the Coxsackie virus B3 (CVB3), with IC50 values of 26.62-252.18 μM, and alkaloids 7, 8, and 17 inhibited influenza virus A/Hanfang/359/95 (H3N2) replication with IC50 values of 63.07-242.46 μM.
    Planta Med. 2006 Jul;72(9):854-6. Epub 2006 Jun 19.
    Quinolizidine alkaloids with anti-HBV activity from Sophora tonkinensis.[Pubmed: 16783704 ]

    METHODS AND RESULTS:
    A new matrine-type alkaloid, (-)-14 beta-hydroxyoxymatrine (1), was isolated from the roots and rhizomes of Sophora tonkinensis Gapnep. (Leguminosae), together with five known matrine-type alkaloids, (-)-14 beta-hydroxymatrine (2), (+)-oxymatrine (3), (+)-matrine (4), (+)-Sophoranol (5), and (-)-5 alpha-hydroxysophocarpine ( 6), as well as with two known cytisine-type alkaloids, (-)-cytisine (7) and (-)- N-methylcytisine (8). Their structures were elucidated by spectroscopic methods.
    CONCLUSIONS:
    Compounds 1, 5 and 7 showed potent anti-HBV activity with an inhibitory potency against HBsAg secretion of 22.6 %, 31.1 % and 33.2 %, and against HBeAg secretion of 30.4 %, 26.3 % and 27.8 %, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7821 mL 18.9107 mL 37.8215 mL 75.643 mL 94.5537 mL
    5 mM 0.7564 mL 3.7821 mL 7.5643 mL 15.1286 mL 18.9107 mL
    10 mM 0.3782 mL 1.8911 mL 3.7821 mL 7.5643 mL 9.4554 mL
    50 mM 0.0756 mL 0.3782 mL 0.7564 mL 1.5129 mL 1.8911 mL
    100 mM 0.0378 mL 0.1891 mL 0.3782 mL 0.7564 mL 0.9455 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    槐定碱; Allomatrine CFN90222 641-39-4 C15H24N2O = 248.36 20mg QQ客服:1413575084
    槐定碱; Sophoridine CFN97172 6882-68-4 C15H24N2O = 248.4 20mg QQ客服:1413575084
    氧化槐定碱; Oxysophoridine CFN90290 54809-74-4 C15H24N2O2 = 264.36 5mg QQ客服:215959384
    氧化槐果碱; Oxysophocarpine CFN98321 26904-64-3 C15H22N2O2 = 262.4 20mg QQ客服:1413575084
    苦参碱; Matrine CFN98835 519-02-8 C15H24N2O = 248.4 20mg QQ客服:2159513211
    12,13-去氢苦参碱; Lemannine CFN92839 58480-54-9 C15H22N2O = 246.4 5mg QQ客服:215959384
    新槐胺; Neosophoramine CFN98875 52932-74-8 C15H20N2O = 244.3 5mg QQ客服:2159513211
    槐果碱; Sophocarpine CFN99182 145572-44-7 C15H22N2O = 246.35 20mg QQ客服:1413575084
    氧化苦参碱; 苦参素; Oxymatrine CFN99805 16837-52-8 C15H24N2O2 = 264.4 20mg QQ客服:1413575084
    槐苦参醇,槐醇; (+)-Sophoranol CFN92840 3411-37-8 C15H24N2O2 = 264.4 5mg QQ客服:2932563308

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