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  • 远志酸

    Polygalacic acid

    远志酸
    产品编号 CFN99108
    CAS编号 22338-71-2
    分子式 = 分子量 C30H48O6 = 504.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Polygala tenuifolia Willd.
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    远志酸 CFN99108 22338-71-2 10mg QQ客服:1413575084
    远志酸 CFN99108 22338-71-2 20mg QQ客服:1413575084
    远志酸 CFN99108 22338-71-2 50mg QQ客服:1413575084
    远志酸 CFN99108 22338-71-2 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(11):14105-21
  • Exp Parasitol.2015, 153:160-4
  • Inflammation2015, 38(1):445-55
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Molecules.2016, 21(6)
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  • Phytochem Anal.2016, 27(5):296-303
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  • Cytotechnology.2017, 69(5):765-773
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  • RSC Advances2017, 86
  • Molecules.2018, 23(3):E615
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  • J Sep Sci.2018, 41(9):1938-1946
  • Primary and Industrial.2018, 52(11)
  • Chemistry of Natural Compounds2018, 54(3):572–576
  • Drug Invention Today2019, 12(6):1303-1306
  • Int J Biol Macromol.2019, 126:653-661
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Journal of Third Military Medical University2019, 41(2):110-115
  • Planta Med.2019, 85(4):347-355
  • ...
  • 生物活性
    Description: Polygalacic acid may exert a significant neuroprotective effect on cognitive impairment, driven in part by the modulation of cholinergic activity and neuroinflammation. Polygalacic acid shows significant postingestive effects on Spodoptera littoralis larvae.
    Targets: AChR | Immunology & Inflammation related
    In vitro:
    J Nat Prod. 2010 Nov 29;73(11):1863-7.
    Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells.[Pubmed: 20939516]

    METHODS AND RESULTS:
    Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D(2) (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1-3 were determined on the basis of spectroscopic data interpretation and chemical transformation.
    CONCLUSIONS:
    Saponins with a platycodigenin or polygalacic acid unit as a sapogenin demonstrated significant inhibitory effects on the proliferation of a small panel of cultured human tumor cells.
    Phytochemistry. 2011 Jun;72(8):743-51.
    Bioactive saponins from Microsechium helleri and Sicyos bulbosus.[Pubmed: 21439597 ]
    Eleven oleanane-type saponins (1-11) have been isolated from Microsechium helleri and Sicyos bulbosus roots and were evaluated for their antifeedant, nematicidal and phytotoxic activities.
    METHODS AND RESULTS:
    Saponins {3-O-β-D-glucopyranosyl (1→3)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-[β-D-xylopyranosyl-(1→3)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside} (1), and {3-O-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-[β-D-xylopyranosyl-(1→3)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside} (2) were also isolated from M. helleri roots together with the two known compounds 3 and 4. Seven known structurally related saponins (5-11) were isolated from S. bulbosus roots. The structures of these compounds were established as bayogenin and polygalacic glycosides using one- and two-dimensional NMR spectroscopy and mass spectrometry. Compounds 7, 10, bayogenin (12) and Polygalacic acid (13) showed significant (p<0.05) postingestive effects on Spodoptera littoralis larvae, compounds 5-11 and 12 showed variable nematicidal effects on Meloydogyne javanica and all tested saponins had variable phytotoxic effects on several plant species (Lycopersicum esculentum, Lolium perenne and Lactuca sativa).
    CONCLUSIONS:
    These are promising results in the search for natural pesticides from the Cucurbitaceae family.
    In vivo:
    Phytomedicine. 2016 Feb 15;23(2):149-55.
    Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice.[Pubmed: 26926176 ]
    Polygala tenuifolia Willd is a Traditional Chinese Medicine used for the treatment of learning and memory deficits.
    METHODS AND RESULTS:
    Triterpenoid saponins, the main bioactive compounds of Polygala tenuifolia Willd, are easily hydrolyzed to Polygalacic acid (PA).Treatment with scopolamine significantly increased the escape latency time, decreased the number of crossings, and shortened the time spent in the target quadrant, while PA reversed these scopolamine-induced effects. PA significantly improved cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increased choline acetyltransferase (ChAT) activity, and elevated levels of acetylcholine (ACh) in the hippocampus and frontal cortex. PA also significantly ameliorated neuroinflammation and oxidative stress in mice.
    CONCLUSIONS:
    These results suggest that PA might exert a significant neuroprotective effect on cognitive impairment, driven in part by the modulation of cholinergic activity and neuroinflammation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9813 mL 9.9067 mL 19.8134 mL 39.6267 mL 49.5334 mL
    5 mM 0.3963 mL 1.9813 mL 3.9627 mL 7.9253 mL 9.9067 mL
    10 mM 0.1981 mL 0.9907 mL 1.9813 mL 3.9627 mL 4.9533 mL
    50 mM 0.0396 mL 0.1981 mL 0.3963 mL 0.7925 mL 0.9907 mL
    100 mM 0.0198 mL 0.0991 mL 0.1981 mL 0.3963 mL 0.4953 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2alpha,3alpha,24-三羟基-12-烯-28-齐墩果酸; 2,3,24-Trihydroxyolean-12-en-28-oic acid CFN99628 150821-16-2 C30H48O5 = 488.7 5mg QQ客服:2159513211
    贝萼皂苷元; 贝萼甙元; Bayogenin CFN90314 6989-24-8 C30H48O5 = 488.70 20mg QQ客服:1413575084
    贝萼皂苷元甲酯; Bayogenin methyl ester CFN92819 22425-81-6 C31H50O5 = 502.4 5mg QQ客服:2932563308
    儿茶酚; Caulophyllogenin CFN91135 52936-64-8 C30H48O5 = 488.7 5mg QQ客服:2932563308
    远志酸; Polygalacic acid CFN99108 22338-71-2 C30H48O6 = 504.71 20mg QQ客服:2932563308
    桔梗皂苷元; Platycodigenin CFN92207 22327-82-8 C30H48O7 = 520.7 10mg QQ客服:1413575084
    美商陆酸; Phytolaccagenic acid CFN91881 54928-05-1 C31H48O6 = 516.71 5mg QQ客服:1148253675
    商陆皂苷元; Phytolaccagenin CFN99844 1802-12-6 C31H48O7 = 532.7 20mg QQ客服:1148253675
    远志酸; Polygalic acid CFN92195 1260-04-4 C29H44O6 = 488.7 20mg QQ客服:215959384
    苜蓿酸; Medicagenic acid CFN93933 599-07-5 C30H46O6 = 502.68 5mg QQ客服:1148253675

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