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  • 儿茶酚

    Caulophyllogenin

    儿茶酚
    产品编号 CFN91135
    CAS编号 52936-64-8
    分子式 = 分子量 C30H48O5 = 488.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Caulophyllum robustum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    儿茶酚 CFN91135 52936-64-8 1mg QQ客服:1457312923
    儿茶酚 CFN91135 52936-64-8 5mg QQ客服:1457312923
    儿茶酚 CFN91135 52936-64-8 10mg QQ客服:1457312923
    儿茶酚 CFN91135 52936-64-8 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Max Rubner-Institut (MRI) (Germany)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Universit?t Basel (Switzerland)
  • University of Amsterdam (Netherlands)
  • Chulalongkorn University (Thailand)
  • Kyoto University (Japan)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Griffith University (Australia)
  • Pennsylvania State University (USA)
  • Nanjing University of Chinese Medicine (China)
  • Complutense University of Madrid (Spain)
  • University of Wollongong (Australia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Shanghai University of TCM (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacol Rep.2019, 71(2):289-298
  • Appl. Sci.2020, 10(16),5482.
  • Phytother Res.2015, 29(7):1088-96
  • The Journal of Korean Medicine2022, 43(3): 79-93.
  • Int J Mol Sci.2022, 23(20):12516.
  • GxABT2022, 2268.2:15515.
  • Sci Rep.2021, 11(1):21038.
  • Analytical methods2019, 11(6)
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • Food Chem.2022, 378:131975.
  • Eur J Pharmacol.2020, 889:173589.
  • Food Chemistry2023, 137837.
  • Nutr Cancer.2022, 1-13.
  • Plant Sci.2020, 301:110656.
  • Phytochemistry.2021, 181:112539.
  • Oncotarget.2017, 8(64):108006-108019
  • Pest Manag Sci.2019, 75(9):2530-2541
  • Biomed Pharmacother.2021, 139:111585.
  • Cell Death Differ.2021, 1-8.
  • J of Health Science and Alternative Medicine2019, 1(1)
  • BMC Complement Med Ther.2023, 23(1):264.
  • Pharm Biol.2022, 60(1):2040-2048.
  • Life (Basel).2022, 12(10):1630.
  • ...
  • 生物活性
    Description: Caulophyllogenin in the inhibition of pro-inflammatory cytokine secretion, including IL-12 p40, IL-6, and TNF-α, and for prevention and treatment of inflammatory diseases.
    Targets: TNF-α | IL Recepter
    In vitro:
    Arch Pharm Res. 2013 Mar;36(3):327-34.
    Inhibitory effects of oleanane-type triterpenes and saponins from the stem bark of Kalopanax pictus on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.[Reference: WebLink]
    Kalopanax pictus (Araliaceae) is a deciduous tree distributed in Korea, Japan, and China. The stem bark of K. pictus has been functionally used as a traditional crude drug for the treatment of various inflammatory diseases.
    METHODS AND RESULTS:
    In the present study, we describe the inhibitory effects of oleanane-type triterpenes and saponins isolated from the stem bark of K. pictus on production of pro-inflammatory cytokines in LPS-stimulated bone marrow-derived dendritic cells. Of the compounds tested, 16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid (1), 4,23,29-trihydroxy-3,4-seco-olean-12-en-3-oate-28-oic acid (2), 3β,6β,23-trihydroxyolean-12-en-28-oic acid 28-O-β-D-glucopyranoside (3), nipponogenin E (6), 3β,6β,23-trihydroxyolean-12-en-28-oic acid (7), and caulophyllogenin (19) significantly inhibited the production of IL-12 p40 and IL-6 with IC50 values ranging from 3.3 to 9.1 μM. Compounds 2, 3, 7, and 19 significantly suppressed the secretion of TNF-α with IC50 ranging from 8.8 to 20.0 μM.
    CONCLUSIONS:
    These data provide scientific support for the use of K. pictus stem bark and its triterpene and saponin components in the inhibition of pro-inflammatory cytokine secretion, including IL-12 p40, IL-6, and TNF-α, and for prevention and treatment of inflammatory diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0462 mL 10.2312 mL 20.4625 mL 40.9249 mL 51.1561 mL
    5 mM 0.4092 mL 2.0462 mL 4.0925 mL 8.185 mL 10.2312 mL
    10 mM 0.2046 mL 1.0231 mL 2.0462 mL 4.0925 mL 5.1156 mL
    50 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8185 mL 1.0231 mL
    100 mM 0.0205 mL 0.1023 mL 0.2046 mL 0.4092 mL 0.5116 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    贝萼皂苷元; 贝萼甙元; Bayogenin CFN90314 6989-24-8 C30H48O5 = 488.70 20mg QQ客服:1413575084
    贝萼皂苷元甲酯; Bayogenin methyl ester CFN92819 22425-81-6 C31H50O5 = 502.4 5mg QQ客服:2056216494
    儿茶酚; Caulophyllogenin CFN91135 52936-64-8 C30H48O5 = 488.7 5mg QQ客服:3257982914
    远志酸; Polygalacic acid CFN99108 22338-71-2 C30H48O6 = 504.71 5mg QQ客服:2159513211
    桔梗皂苷元; Platycodigenin CFN92207 22327-82-8 C30H48O7 = 520.7 10mg QQ客服:1413575084
    美商陆酸; Phytolaccagenic acid CFN91881 54928-05-1 C31H48O6 = 516.71 5mg QQ客服:2159513211
    商陆皂苷元; Phytolaccagenin CFN99844 1802-12-6 C31H48O7 = 532.7 20mg QQ客服:3257982914
    远志酸; Polygalic acid CFN92195 1260-04-4 C29H44O6 = 488.7 20mg QQ客服:3257982914
    苜蓿酸; Medicagenic acid CFN93933 599-07-5 C30H46O6 = 502.68 5mg QQ客服:1457312923
    远志皂苷元; Senegenin CFN99109 2469-34-3 C30H45ClO6 = 537.14 20mg QQ客服:215959384

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