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  • 黄柏碱

    Phellodendrine

    黄柏碱
    产品编号 CFN99143
    CAS编号 6873-13-8
    分子式 = 分子量 C20H24NO4 = 342.4
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Alkaloids
    植物来源 The peels of Phellodendron chinense Schneid.
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    黄柏碱 CFN99143 6873-13-8 10mg QQ客服:3257982914
    黄柏碱 CFN99143 6873-13-8 20mg QQ客服:3257982914
    黄柏碱 CFN99143 6873-13-8 50mg QQ客服:3257982914
    黄柏碱 CFN99143 6873-13-8 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • University of Sao Paulo (Brazil)
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  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tumour Biol.2015, 36(9):7027-34
  • Food Research International2016, 106-113
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Nat Prod Sci.2016, 22(2)
  • Nat Plants.2016, 3:16205
  • Int J Oncol.2016, 49(4):1497-504
  • Sci Rep. 2017, 12953(7)
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • J Hematol Oncol.2018, 11(1):112
  • Korean J of Medicinal Crop Science2018, 220-226
  • Molecules.2018, 23(3):E615
  • Molecules.2018, 23(9):E2121
  • Toxicol In Vitro.2018, 52:94-105
  • J Nat Med.2018, 72(3):734-744
  • Plant Physiol Biochem.2019, 144:355-364
  • Molecules.2019, 24(10):E1926
  • Molecules.2019, 24(6):E1177
  • J of Dentistry & Oral Health2019, 2641-1962
  • Phytother Res.2019, 33(7):1784-1793
  • Phytomedicine.2019, 56:48-56
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: Phellodendrine has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis, it also has antioxidant, and anti-inflammatory effects. Phellodendrine can suppress local semisyngeneic GvH reactions and systemic allogeneic GvH reactions in X-ray irradiated recipient mice, it also can suppress the induction phase of sheep red blood cell (SRBC)-induced delayed type hypersensitivity in mice and tuberculin-induced delayed type hypersensitivity in guinea pigs, Phellodendrine can down-regulating AKT, IKK, NF-kB phosphorylation and COX-2 expression induced by AAPH, it also ameliorates the ROS-mediated inflammatory response.
    Targets: Akt | IkB | NF-kB | COX | ROS | IL Receptor | IKK
    In vitro:
    J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Sep 1;1029-1030:95-101.
    Pharmacokinetic studies of phellodendrine in rat plasma and tissues after intravenous administration using ultra-high performance liquid chromatography-tandem mass spectrometry.[Pubmed: 27428451 ]
    Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis. However, few investigations have been conducted for the pharmacokinetic study of phellodendrine.
    METHODS AND RESULTS:
    Thus, a rapid, simple and reliable ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UHPLC-QQQ MS/MS) method has been established for quantification of phellodendrine in rat plasma and tissues by using magnoflorine as internal standard. The chromatographic separation was achieved on an Agilent ZORBAX SB-C18 column (4.6mm×50mm, 1.8μm) by gradient elution using 0.1% aqueous formic acid (A) and methanol (B). Triple quadrupole mass detection with multiple reaction monitoring mode was used to monitor the ion transitions, at m/z 342.20→192.20 for phellodendrine and m/z 342.20→58.20 for internal standard, respectively. The developed method was fully validated and successfully applied to the pharmacokinetics and tissue distribution study of phellodendrine after intravenous administration. The lower limits of quantification were 0.5ng/mL for plasma samples, 2.5ng/g for brain and 1ng/g for other tested tissues. Precisions and accuracy values were within the Food and Drug Administration acceptance criteria, the recovery and matrix effects were between 87.8-113.5%. The area under the curve (AUC0-t) ranged from 15.58 to 57.41mg/L min and Cmax were between 1.63-4.93mg/L.
    CONCLUSIONS:
    The results showed that phellodendrine was eliminated in 120min in plasma and most of tissues and the highest concentrations of phellodendrine were found in the kidney. This study may provide a basis for the further study of phellodendrine.
    In vivo:
    Planta Med. 1995 Feb;61(1):45-9.
    Principle of the bark of Phellodendron amurense to suppress the cellular immune response: effect of phellodendrine on cellular and humoral immune responses.[Pubmed: 7700991]
    Previously we have isolated the quaternary base alkaloids, magnoflorine and phellodendrine, from Phellodendri Cortex (cortex of Phellodendron amurense Rupr., Rutaceae) as the biologically active principles to suppress local graft-versus-host (GvH) reactions in mice.
    METHODS AND RESULTS:
    In this paper, we focus on phellodendrine. Phellodendrine suppressed local semisyngeneic GvH reactions and systemic allogeneic GvH reactions in X-ray irradiated recipient mice. Phellodendrine also suppressed the induction phase of sheep red blood cell (SRBC)-induced delayed type hypersensitivity in mice and tuberculin-induced delayed type hypersensitivity in guinea pigs, but did not suppress the effector phase of these reactions.
    CONCLUSIONS:
    Surprisingly, phellodendrine, unlike prednisolone and cyclophosphamide, did not affect antibody production in mice to SRBC. Phellodendrine was expected to be a valuable new type of immunosuppressor against the cellular immune response.
    Life Sci. 2016 Jul 15;157:97-106.
    The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos.[Pubmed: 27234894 ]
    This study is to investigate the effect of phellodendrine (PHE) against AAPH-induced oxidative stress and find out the biological mechanism of PHE by using the zebrafish embryo model.
    METHODS AND RESULTS:
    After treatments by AAPH or PHE, the mortality and heartbeat of zebrafish embryos were recorded and the production of reactive oxygen species (ROS), lipid-peroxidation and the rate of cell death were detected by fluorescence spectrophotometry respectively. Whereafter, the pathways of PHE against AAPH-induced oxidative stress were screened by inhibitors to explore its biological mechanism. The related genes and proteins expressions were analyzed by real-time quantitative reverse-transcription polymerase-chain-reaction (qRT-PCR) and western blotting. The PHE obviously improved the decreased survival rate and abnormally elevated heart-beating rate of zebrafish embryos caused by AAPH. Especially 200μg/mL of PHE make the survival rate increased to 90.26±1.40% at 72hfp and the heartbeat back to normal. Besides, AAPH caused a significant increase in the production of reactive oxygen species (ROS), lipid-peroxidation and cell death rate, all of which could be decreased after PHE treatment dose-dependently. And PHE exerted the protective activity against AAPH-induced oxidative stress through down-regulating AKT phosphorylation and NF-kB3 expression, which associate with modulation of IKK phosphorylation in zebrafish embryos.
    CONCLUSIONS:
    The PHE showed a good antioxidant effect in vivo, and the mechanism has been stated that the PHE can down-regulating AKT, IKK, NF-kB phosphorylation and COX-2 expression induced by AAPH. Moreover, the PHE also ameliorated the ROS-mediated inflammatory response.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9206 mL 14.6028 mL 29.2056 mL 58.4112 mL 73.014 mL
    5 mM 0.5841 mL 2.9206 mL 5.8411 mL 11.6822 mL 14.6028 mL
    10 mM 0.2921 mL 1.4603 mL 2.9206 mL 5.8411 mL 7.3014 mL
    50 mM 0.0584 mL 0.2921 mL 0.5841 mL 1.1682 mL 1.4603 mL
    100 mM 0.0292 mL 0.146 mL 0.2921 mL 0.5841 mL 0.7301 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Mangochinine; Mangochinine CFN98051 209115-67-3 C19H22NO4 = 328.4 5mg QQ客服:1148253675
    别隐品碱; Allocryptopine CFN98254 24240-04-8 C21H23NO5 = 369.4 5mg QQ客服:3257982914
    黄柏碱; Phellodendrine CFN99143 6873-13-8 C20H24NO4 = 342.4 20mg QQ客服:1413575084
    盐酸黄柏碱; Phellodendrine chloride CFN99144 104112-82-5 C20H24NO4.Cl = 377.85 20mg QQ客服:1413575084
    氢化原阿片碱; Hydroprotopine CFN99388 128397-41-1 C20H20NO5 = 354.4 20mg QQ客服:2159513211
    原阿片碱; Protopine CFN99399 130-86-9 C20H19NO5 = 353.4 20mg QQ客服:1413575084
    Coulteropine; Coulteropine CFN89127 6014-62-6 C21H21NO6 = 383.4 5mg QQ客服:1148253675
    1-Methoxyallocryptopine; 1-Methoxyallocryptopine CFN89163 56743-52-3 C22H25NO6 = 399.44 5mg QQ客服:1148253675

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