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    产品编号 CFN98254
    CAS编号 24240-04-8
    分子式 = 分子量 C21H23NO5 = 369.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Macleaya cordata
    产品名称 产品编号 CAS编号 包装 QQ客服
    别隐品碱 CFN98254 24240-04-8 1mg QQ客服:3257982914
    别隐品碱 CFN98254 24240-04-8 5mg QQ客服:3257982914
    别隐品碱 CFN98254 24240-04-8 10mg QQ客服:3257982914
    别隐品碱 CFN98254 24240-04-8 20mg QQ客服:3257982914
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  • 生物活性
    Description: Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis; it increases mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Allocryptopine induces a relaxing effect on the ileum by inhibiting phosphodiesterase enzyme, and thus elevating cellular cAMP and its contractile effect on the urinary bladder by affecting alpha-adrenergic receptors in this tissue, it can block human ether-a-go-go related gene (hERG) potassium channels expressed in HEK293 cells.
    Targets: cAMP | P450 (e.g. CYP17) | Potassium channel
    In vitro:
    Acta Pharmacol Sin. 2013 Jun;34(6):847-58.
    Allocryptopine and benzyltetrahydropalmatine block hERG potassium channels expressed in HEK293 cells.[Pubmed: 23524574]
    Allocryptopine (ALL) is an alkaloid extracted from Corydalis decumbens (Thunb) Pers. Papaveraceae, whereas benzyltetrahydropalmatine (BTHP) is a derivative of tetrahydropalmatine extracted from Corydalis ambigua (Pall) Cham et Schlecht. The aim of this study was to investigate the effects of ALL and BTHP on the human ether-a-go-go related gene (hERG) current expressed in HEK293 cells.
    Cultured HEK293 cells were transiently transfected with hERG channel cDNA plasmid pcDNA3.1 using Lipofectamine. The whole-cell current IHERG was evoked and recorded using Axon MultiClamp 700B amplifier. The drugs were applied via supserfusion. Both ALL and BTHP reversibly suppressed the amplitude and density of IHERG in concentration- and voltage-dependent manners (the respective IC50 value was 49.65 and 22.38 μmol/L). BTHP (30 μmol/L) caused a significant negative shift of the steady-state inactivation curve of IHERG, while ALL (30 μmol/L) did not affect the steady-state inactivation of IHERG. Furthermore, BTHP, but not ALL, shortened the time constants of fast inactivation and slow time constants of deactivation of IHERG. But both the drugs markedly lengthened the time constants for recovery of IHERG from inactivation. Using action potential waveform pulses, it was found that both the drugs at 30 μmol/L significantly suppressed the current densities in the late phase of action potential, but did not significantly affect the current densities in the early phase of action potential.
    Both ALL and BTHP derived from Chinese herbs potently block hERG current.
    In vivo:
    Gen Pharmacol. 1997 Oct;29(4):621-3.
    Effects of allocryptopine, an alkaloid isolated from Glaucium arabicum on rat isolated ileum and urinary bladder.[Pubmed: 9352312]
    1. The alkaloid, Allocryptopine, was isolated from the chloroform extract of Glaucium arabicum.
    2. The effect of Allocryptopine on urinary bladder and ileal smooth muscles was investigated in this study. 3. Allocryptopine, in concentrations from 1 x 10(-5) to 3 x 10(-3) M caused a concentration-dependent contraction of rat isolated urinary bladder and a concentration-dependent relaxation of rat ileal smooth muscles. 4. Theophylline (10(-5) M) shifted to the left the Allocryptopine concentration-effect curve on ileum and increased the maximum inhibitory effect of Allocryptopine. 5. Methylene blue (10(-3) M) had no significant effect on the concentration-effect curve of Allocryptopine of the ileum. 6. Phentolamine (10(-6) M) shifted to the right the Allocryptopine concentration-effect curve of urinary bladder.
    7. These observations suggest that Allocryptopine induces a relaxing effect on the ileum by inhibiting phosphodiesterase enzyme, and thus elevating cellular cAMP and its contractile effect on the urinary bladder by affecting alpha-adrenergic receptors in this tissue.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7071 mL 13.5355 mL 27.0709 mL 54.1419 mL 67.6773 mL
    5 mM 0.5414 mL 2.7071 mL 5.4142 mL 10.8284 mL 13.5355 mL
    10 mM 0.2707 mL 1.3535 mL 2.7071 mL 5.4142 mL 6.7677 mL
    50 mM 0.0541 mL 0.2707 mL 0.5414 mL 1.0828 mL 1.3535 mL
    100 mM 0.0271 mL 0.1354 mL 0.2707 mL 0.5414 mL 0.6768 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Mangochinine; Mangochinine CFN98051 209115-67-3 C19H22NO4 = 328.4 5mg QQ客服:1413575084
    别隐品碱; Allocryptopine CFN98254 24240-04-8 C21H23NO5 = 369.4 5mg QQ客服:2932563308
    黄柏碱; Phellodendrine CFN99143 6873-13-8 C20H24NO4 = 342.4 20mg QQ客服:215959384
    盐酸黄柏碱; Phellodendrine chloride CFN99144 104112-82-5 C20H24NO4.Cl = 377.85 20mg QQ客服:2932563308
    氢化原阿片碱; Hydroprotopine CFN99388 128397-41-1 C20H20NO5 = 354.4 20mg QQ客服:1148253675
    原阿片碱; Protopine CFN99399 130-86-9 C20H19NO5 = 353.4 20mg QQ客服:215959384
    Coulteropine; Coulteropine CFN89127 6014-62-6 C21H21NO6 = 383.4 5mg QQ客服:1413575084
    1-Methoxyallocryptopine; 1-Methoxyallocryptopine CFN89163 56743-52-3 C22H25NO6 = 399.44 5mg QQ客服:1413575084





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