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  • 4',5-二羟基- 3,6,7-三甲氧基黄酮

    Penduletin

    4',5-二羟基- 3,6,7-三甲氧基黄酮
    产品编号 CFN98957
    CAS编号 569-80-2
    分子式 = 分子量 C18H16O7 = 344.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Laggera pterodonta
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4',5-二羟基- 3,6,7-三甲氧基黄酮 CFN98957 569-80-2 1mg QQ客服:1413575084
    4',5-二羟基- 3,6,7-三甲氧基黄酮 CFN98957 569-80-2 5mg QQ客服:1413575084
    4',5-二羟基- 3,6,7-三甲氧基黄酮 CFN98957 569-80-2 10mg QQ客服:1413575084
    4',5-二羟基- 3,6,7-三甲氧基黄酮 CFN98957 569-80-2 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Canterbury (New Zealand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anticancer Res.2014, 34(7):3505-9
  • Pharmacogn Mag.2015, 11:S585-91
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Int J Mol Med.2016, 37(2):501-8
  • Front Pharmacol.2016, 7:460
  • Free Radic Biol Med.2016, 97:307-319
  • J Ethnopharmacol.2017, 196:75-83
  • Molecules.2017, 22(6)
  • Pharm Biol.2017, 55(1):360-366
  • Front Plant Sci.2017, 8:723
  • J Nat Prod.2017, 80(4):854-863
  • European Journal of Integrative Medicine2018, 20:165-172
  • Korean J Dent Mater.2018, 45(2):139-146
  • J Cancer.2019, 10(23):5843-5851
  • Drug Invention Today2019, 12(6):1303-1306
  • J Ethnopharmacol.2019, 228:132-141
  • Saudi Pharm J.2019, 27(1):145-153
  • Food Chem.2019, 275:746-753
  • Pak J Pharm Sci.2019, 32(6)
  • J Agric Food Chem.2019, 67(27):7748-7754
  • J Clin Med.2019, 8(10):E1664
  • Food and Chemical Toxicology2020, 111221
  • Antioxidants (Basel).2020, 9(2):E120
  • ...
  • 生物活性
    Description: Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Penduletin has strong activity in vitro against EV71 with low cytotoxicity.
    Targets: VEGFR | TGF-β/Smad | PGE | COX | Antifection
    In vitro:
    Eur J Pharm Sci. 2011 Oct 9;44(3):392-8.
    Inhibition of enterovirus 71 replication by chrysosplenetin and penduletin.[Pubmed: 21914477]
    In recent years, enterovirus 71 (EV71) infections have caused an increasing epidemic in young children, accompanying with more severe nervous system disease and more deaths. Unfortunately, there is no specific medication for it so far.
    METHODS AND RESULTS:
    Here we investigated the anti-EV71 activity of chrysosplenetin and penduletin, two o-methylated flavonols isolated from the leaves of Laggera pterodonta. These two compounds were found to have strong activity in vitro against EV71 with low cytotoxicity. In the cytopathic effect (CPE) inhibition assays, both plaque reduction assay and virus yield inhibition assay, the compounds showed a similar 50% inhibitory concentration (IC(50)) value of about 0.20 μM. The selectivity indices (SI) of chrysosplenetin and penduletin were 107.5 and 655.6 in African green monkey kidney (Vero) cells, and 69.5 and 200.5 in human rhabdomyosarcoma (RD) cells, accordingly. The preliminary mechanism analysis indicates that they function not through blocking virus entry or inactivating virus directly but inhibiting viral RNA replication. In the time-of-addition assay, both compounds inhibited progeny virus production and RNA replication by nearly 100% when introduced within 4h post infection. In addition to EV71, both compounds inhibited several other human enteroviruses with similar efficacy.
    CONCLUSIONS:
    These findings provide a significant lead for the discovery of anti-EV71 drug.
    Oncol Res. 2005;15(2):59-68.
    Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae).[Pubmed: 16119003 ]
    The CH3OH-CH2Cl2 extract of an Indian collection (entire plant) of Gynandropsis gynandra (L.) Briq. was separated based on bioassay results employing cancer cell lines.
    METHODS AND RESULTS:
    Six cancer cell growth inhibitors were isolated and found to be known flavone apegenin (4) and flavonols 1-3, 5, and 6. The structure of flavonol 2 was confirmed by X-ray crystal structure determination. All of the five flavonols (1-3, 5, 6) inhibited the murine P388 lymphocytic leukemia cell line with ED50 values of 3.0, 9.2, 4.0, 0.37, and 3.9 microg/ml, respectively.
    CONCLUSIONS:
    All six of the flavonoids (1-6) also exhibited activity against a panel of six human cancer cell lines. Penduletin (3) inhibited growth of the Gram-negative pathogen Neisseria gonorrhoeae and apegenin (4) inhibited growth of the Gram-positive opportunist Enterococcus faecalis.
    Planta Med. 2006 Jan;72(1):72-4.
    Flavonoids from Artemisia copa with anti-inflammatory activity.[Pubmed: 16450301 ]
    Bioactivity-guided fractionation of the dichloromethane and ethanol extracts from the aerial parts of Artemisia copa led to the isolation of the flavonoids spinacetin, jaceosidin, axillarin, Penduletin, tricin and chrysoeriol.
    METHODS AND RESULTS:
    These compounds were studied for possible inhibitory activity on the generation of inflammatory mediators in a cell line of mouse macrophages (RAW 264.7) stimulated with lipopolysaccharide. Spinacetin and jaceosidin weakly inhibited nitric oxide production whereas all flavonoids reduced prostaglandin E2 levels to different extents. The most active flavonoid was jaceosidin that inhibited cyclooxygenase-2 activity in a concentration-dependent manner with an IC50 value of 2.8 microM. In addition, the other flavonoids partially inhibited synovial phospholipase A2 activity.
    CONCLUSIONS:
    These mechanisms may provide a basis for explaining the anti-inflammatory activity of this plant.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9044 mL 14.5222 mL 29.0444 mL 58.0889 mL 72.6111 mL
    5 mM 0.5809 mL 2.9044 mL 5.8089 mL 11.6178 mL 14.5222 mL
    10 mM 0.2904 mL 1.4522 mL 2.9044 mL 5.8089 mL 7.2611 mL
    50 mM 0.0581 mL 0.2904 mL 0.5809 mL 1.1618 mL 1.4522 mL
    100 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5809 mL 0.7261 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7-二乙酰氧基-3,4',8-三甲氧基黄酮; 5,7-Diacetoxy-3,4',8-trimethoxyflavone CFN98818 5128-43-8 C22H20O9 = 428.4 5mg QQ客服:2932563308
    4',5,7-三羟基 3,6,8-三甲氧基黄酮; 4',5,7-Trihydroxy 3,6,8-trimethoxyflavone CFN70413 57393-71-2 C18H16O8 = 360.3 5mg QQ客服:215959384
    Calycopterin; Calycopterin CFN70374 481-52-7 C19H18O8 = 374.4 5mg QQ客服:215959384
    5,7-二羟基-3,4',6,8-四甲氧基黄酮; Araneosol CFN98797 50461-86-4 C19H18O8 = 374.4 5mg QQ客服:215959384
    2',3,5,7-四羟基黄酮; 2',3,5,7-Tetrahydroxyflavone CFN70373 480-15-9 C15H10O6 = 286.2 5mg QQ客服:2932563308
    山奈酚; Kaempferol CFN98838 520-18-3 C15H10O6 = 286.2 20mg QQ客服:3257982914
    3,4',7-三乙酰山奈酚; 3,4',7-三乙酸堪非醇酯; Kaempferol 3,4,7-triacetate CFN99479 143724-69-0 C21H16O9 = 412.4 5mg QQ客服:2159513211
    四乙酰山奈酚; 四乙酸堪非醇酯; Kaempferol tetraacetate CFN99686 16274-11-6 C23H18O10 = 454.4 5mg QQ客服:2159513211
    异山柰素; Isokaempferide CFN93002 1592-70-7 C16H12O6 = 300.3 5mg QQ客服:215959384
    5-甲氧基山奈酚; 5-甲氧基莰非醇; Kaempferol 5-methyl ether CFN92510 22044-80-0 C16H12O6 = 300.3 5mg QQ客服:3257982914

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