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    荷叶碱

    Nuciferine

    荷叶碱
    产品编号 CFN99733
    CAS编号 475-83-2
    分子式 = 分子量 C19H21NO2 = 295.38
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Alkaloids
    植物来源 The leaves of Nelumbo nucifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    荷叶碱 CFN99733 475-83-2 10mg QQ客服:1413575084
    荷叶碱 CFN99733 475-83-2 20mg QQ客服:1413575084
    荷叶碱 CFN99733 475-83-2 50mg QQ客服:1413575084
    荷叶碱 CFN99733 475-83-2 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Bordeaux (France)
  • Agricultural Research Organization (ARO) (Israel)
  • Shanghai University of TCM (China)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Universidad de La Salle (Mexico)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • University of Wisconsin-Madison (USA)
  • Universidad Miguel Hernández (Spain)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • The Institute of Cancer Research (United Kingdom)
  • Pennsylvania State University (USA)
  • Monash University Malaysia (Malaysia)
  • Weizmann Institute of Science (Israel)
  • Sanford Burnham Medical Research Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • J Agric Food Chem.2017, 65(13):2670-2676
  • Nutrients.2018, 10(12)
  • Nutrients.2018, 10(7)
  • Anal Chim Acta.2018, 1039:162-171
  • European Journal of Integrative Medicine2018, 20:165-172
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Nat Prod Sci.2018, 24(2):109-114
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Clin Transl Oncol.2019, 10.1007
  • World J Mens Health.2019, 10.5534
  • Molecules.2019, 24(19):E3417
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Planta Med.2019, 85(9-10):766-773
  • Appl. Sci.2020, 10,1304
  • Genes Genomics.2020, 10.1007
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • Molecules.2020, 25(3):734
  • BMC Complement Med Ther. 2020, 20(1):91.
  • Evid Based Complement Alternat Med.2020, 2020:1970349.
  • Drug Dev Res.2020, doi: 10.1002
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • ...
  • 生物活性
    Description: Nuciferine possesses anti-diabetic, anti-obesity, anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, vasorelaxant, and insulin secretagogue activities. Nuciferine may be potential for the prevention and treatment of hyperuricemia with kidney inflammation. It inhibited tumor-promoting effect of nicotine involving Wnt/β-catenin signaling in non-small cell lung cancer.
    Targets: GLUT | TLR | NF-kB | IL Receptor | NOS | NO | Serine | Calcium Channel | TNF-α | Bcl-2/Bax | VEGFR
    In vitro:
    Br J Pharmacol. 2014 Nov 19.
    Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms.[Pubmed: 25409881]
    Nuciferine, a constituent of lotus leaf, is an aromatic ring-containing alkaloid, with antioxidative properties. We hypothesize Nuciferine might affect vascular reactivity. This study aimed at determining the effects of Nuciferine on vasomotor tone and the underlying mechanism.
    METHODS AND RESULTS:
    Nuciferine-induced relaxations in rings of rat main mesenteric arteries were measured by wire myographs. Endothelial NOS (eNOS) was determined by immunoblotting. Intracellular NO production in HUVECs and Ca2+ level in both HUVECs and vascular smooth muscle cells (VSMCs) from rat mesenteric arteries were assessed by fluorescence imaging. Nuciferine induced relaxations in arterial segments pre-contracted by KCl or phenylephrine. Nuciferine-elicited arterial relaxations were reduced by removal of endothelium or by pretreatment with the eNOS inhibitor L-NAME or the NO-sensitive guanylyl cyclase inhibitor ODQ. In HUVECs, the phosphorylation of eNOS at Ser1177 and increase in cytosolic NO level induced by Nuciferine were mediated by extracellular Ca2+ influx. Under endothelium-free conditions, Nuciferine attenuated CaCl2 -induced contraction in Ca2+ -free depolarizing medium. In the absence of extracellular calcium, Nuciferine relieved the vasoconstriction induced by phenylephrine and the addition of CaCl2 . Nuciferine also suppressed Ca2+ influx in Ca2+ -free K+ -containing solution in VSMCs.
    CONCLUSIONS:
    Nuciferine has a vasorelaxant effect via both endothelium-dependent and -independent mechanisms. These results suggest that Nuciferine may have a therapeutic effect on vascular diseases associated with aberrant vasoconstriction.
    In vivo:
    PLoS One. 2013 May 15;8(5):e63770.
    Nuciferine prevents hepatic steatosis and injury induced by a high-fat diet in hamsters.[Pubmed: 23691094]
    Nuciferine is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn that possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. However, it is currently unknown whether Nuciferine can benefit hepatic lipid metabolism.
    METHODS AND RESULTS:
    In the current study, male golden hamsters were randomly divided into four groups fed a normal diet, a high-fat diet (HFD), or a HFD supplemented with Nuciferine (10 and 15 mg/kg·BW/day). After 8 weeks of intervention, HFD-induced increases in liver and visceral adipose tissue weight, dyslipidemia, liver steatosis, and mild necroinflammation in hamsters were analyzed. Nuciferine supplementation protected against HFD-induced changes, alleviated necroinflammation, and reversed serum markers of metabolic syndrome in hamsters fed a HFD. RT-PCR and western blot analyses revealed that hamsters fed a HFD had up-regulated levels of genes related to lipogenesis, increased free fatty acid infiltration, and down-regulated genes involved in lipolysis and very low density lipoprotein secretion. In addition, gene expression of cytochrome P4502E1 and tumor necrosis factor-α were also increased in the HFD group. Nuciferine supplementation clearly suppressed HFD-induced alterations in the expression of genes involved in lipid metabolism.
    CONCLUSIONS:
    Nuciferine supplementation ameliorated HFD-induced dyslipidemia as well as liver steatosis and injury. The beneficial effects of Nuciferine were associated with altered expression of hepatic genes involved in lipid metabolism.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3855 mL 16.9273 mL 33.8547 mL 67.7094 mL 84.6367 mL
    5 mM 0.6771 mL 3.3855 mL 6.7709 mL 13.5419 mL 16.9273 mL
    10 mM 0.3385 mL 1.6927 mL 3.3855 mL 6.7709 mL 8.4637 mL
    50 mM 0.0677 mL 0.3385 mL 0.6771 mL 1.3542 mL 1.6927 mL
    100 mM 0.0339 mL 0.1693 mL 0.3385 mL 0.6771 mL 0.8464 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    荷包牡丹碱; Dicentrine CFN92331 517-66-8 C20H21NO4 = 339.4 5mg QQ客服:2932563308
    克班宁; Crebanine CFN98275 25127-29-1 C20H21NO4 = 339.4 20mg QQ客服:1457312923
    千金藤碱; Stephanine CFN98828 517-63-5 C19H19NO3 = 309.4 5mg QQ客服:1457312923
    O-去甲基荷叶碱 ; O-Nornuciferine CFN96770 3153-55-7 C18H19NO2 = 281.35 5mg QQ客服:3257982914
    荷叶碱; Nuciferine CFN99733 475-83-2 C19H21NO2 = 295.38 20mg QQ客服:2932563308
    N-甲基荷叶碱; N-Methylnuciferine CFN96064 754919-24-9 C20H24NO2 = 310.4 5mg QQ客服:1413575084
    (-)-巴婆碱; Asimilobine CFN96772 6871-21-2 C17H17NO2 = 267.32 5mg QQ客服:2159513211
    N-去甲基荷叶碱; 原荷叶碱; N-Nornuciferine CFN96149 4846-19-9 C18H19NO2 = 281.4 20mg QQ客服:3257982914
    北美鹅掌楸尼定碱; Lirinidine CFN91037 54383-28-7 C18H19NO2 = 281.4 10mg QQ客服:2056216494
    去氢海罂粟碱; Dehydroglaucine CFN90406 22212-26-6 C21H23NO4 = 353.41 5mg QQ客服:2056216494

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