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  • 千金藤碱

    Stephanine

    千金藤碱
    产品编号 CFN98828
    CAS编号 517-63-5
    分子式 = 分子量 C19H19NO3 = 309.4
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Alkaloids
    植物来源 The roots of Stephania japonica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    千金藤碱 CFN98828 517-63-5 1mg QQ客服:3257982914
    千金藤碱 CFN98828 517-63-5 5mg QQ客服:3257982914
    千金藤碱 CFN98828 517-63-5 10mg QQ客服:3257982914
    千金藤碱 CFN98828 517-63-5 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mahidol University (Thailand)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Osmania University (India)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Aarhus University (Denmark)
  • Kyushu University (Japan)
  • University of Malaya (Malaysia)
  • Calcutta University (India)
  • Northeast Normal University Changchun (China)
  • Tohoku University (Japan)
  • Ateneo de Manila University (Philippines)
  • Florida A&M University (USA)
  • Cornell University (USA)
  • Massachusetts General Hospital (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutrients.2023, 15(6):1417.
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • Sci Rep.2018, 8:15059
  • Analytical Letters.2020, doi 10.1008
  • Appl. Sci.2022, 12(17), 8646.
  • Molecules.2022, 27(13):4227.
  • Clin Transl Med.2021, 11(5):e392.
  • Front Microbiol.2019, 10:2806
  • Plant Foods Hum Nutr.2020, 10.1007
  • Environ Toxicol.2021, doi: 10.1002
  • Front Pharmacol.2022, 13:906763.
  • Appl. Sci.2021, 11(19),9343.
  • Kasetsart University2022, ethesis.1144.
  • Food Chem.2020, 327:126992.
  • Food Funct.2021, 12(13):5892-5902.
  • Biosci Rep.2018, 38(4)
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Process Biochemistry2019, 87:213-220
  • VNU Journal of Science2023, No. 20.
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Viruses.2021, 13(11):2118.
  • Molecules.2019, 24(20):3755
  • ...
  • 生物活性
    Description: l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activities with IC(50) ranged from 1.2 uM to 52.3 uM. Stephanine and crebanine have high inhibitory activity against gram-positive animal pathogenic bacteria, with MIC values of 0.078-0.312g/l, but low inhibitory activity against gram-negative animal pathogenic bacteria, they also inhibit hyphal growth of the plant pathogens Cercospora kaki.
    Targets: Adrenergic Receptor | Antifection
    In vitro:
    Food Chemistry,2011,124(4):1556-60。
    Antimicrobial activity of extract and two alkaloids from traditional Chinese medicinal plant Stephania dielsiana[Reference: WebLink]

    METHODS AND RESULTS:
    Two alkaloids, Stephanine and crebanine, were isolated from tubers of the traditional Chinese medicinal plant Stephania dielsiana, using an activity-directed isolation method, and inhibitory activity of methanol extract, Stephanine and crebanine against ten animal pathogenic bacteria and eight plant pathogenic fungi was evaluated in vitro. The results showed that extract from S. dielsiana exhibited high inhibitory activity against five gram-positive and four gram-negative animal pathogenic bacteria, with MIC values of 0.625-7.5g/l; Stephanine and crebanine had high inhibitory activity against gram-positive animal pathogenic bacteria, with MIC values of 0.078-0.312g/l, but low inhibitory activity against gram-negative animal pathogenic bacteria.
    CONCLUSIONS:
    Methanol extract, Stephanine and crebanine also inhibited hyphal growth of the plant pathogens Cercospora kaki, Gymnosporangium haraeanum, Pyricularia oryzae, Rhizoctonia solani and Colletotrichum graminicola, and spores germination of Thielaviopsis paradoxa, Fusarium oxysporum f. sp. niveum, Sphaceloma fawcettii and G. haraeanum.
    J Ethnopharmacol. 2013 Jan 9;145(1):381-5.
    New antiplasmodial alkaloids from Stephania rotunda.[Pubmed: 23127648 ]

    METHODS AND RESULTS:
    A new aporphine alkaloid named vireakine (2) along with two known alkaloids Stephanine (1) and pseudopalmatine (8), described for the first time in Stephania rotunda, and together five known alkaloids tetrahydropalmatine (3), xylopinine (4), roemerine (5), cepharanthine (6) and palmatine (7) were isolated and identified. The structure of the new alkaloid was established on the basis of 1D and 2D NMR experiments and mass spectrometry. The compounds were evaluated for their in vitro antiplasmodial and cytotoxic activities. All tested compounds showed significant antiplasmodial activities with IC(50) ranged from 1.2 μM to 52.3 μM with a good selectivity index for pseudopalmatine with IC(50) of 2.8 μM against W2 strain of Plasmodium falciparum and IC(50)>25 μM on K562S cells.
    CONCLUSIONS:
    This study provides evidence to support the use of Stephania rotunda for the treatment of malaria and/or fever by the healers. Alkaloids of the tuber exhibited antiplasmodial activity and particularly cepharanthine and pseudopalmatine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2321 mL 16.1603 mL 32.3206 mL 64.6412 mL 80.8016 mL
    5 mM 0.6464 mL 3.2321 mL 6.4641 mL 12.9282 mL 16.1603 mL
    10 mM 0.3232 mL 1.616 mL 3.2321 mL 6.4641 mL 8.0802 mL
    50 mM 0.0646 mL 0.3232 mL 0.6464 mL 1.2928 mL 1.616 mL
    100 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.6464 mL 0.808 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (-)-巴婆碱; Asimilobine CFN96772 6871-21-2 C17H17NO2 = 267.32 5mg QQ客服:1457312923
    N-去甲基荷叶碱; 原荷叶碱; N-Nornuciferine CFN96149 4846-19-9 C18H19NO2 = 281.4 20mg QQ客服:3257982914
    北美鹅掌楸尼定碱; Lirinidine CFN91037 54383-28-7 C18H19NO2 = 281.4 10mg QQ客服:215959384
    去氢海罂粟碱; Dehydroglaucine CFN90406 22212-26-6 C21H23NO4 = 353.41 5mg QQ客服:215959384
    去氢克班宁; Dehydrocrebanine CFN97265 77784-22-6 C20H19NO4 = 337.4 5mg QQ客服:215959384
    N-甲基瓜馥木碱甲; N-Methylcalycinine CFN97425 86537-66-8 C19H19NO4 = 325.4 5mg QQ客服:1413575084
    荷包牡丹碱; Dicentrine CFN92331 517-66-8 C20H21NO4 = 339.4 5mg QQ客服:3257982914
    克班宁; Crebanine CFN98275 25127-29-1 C20H21NO4 = 339.4 20mg QQ客服:1457312923
    千金藤碱; Stephanine CFN98828 517-63-5 C19H19NO3 = 309.4 5mg QQ客服:1457312923
    O-去甲基荷叶碱 ; O-Nornuciferine CFN96770 3153-55-7 C18H19NO2 = 281.35 5mg QQ客服:2159513211

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