南烛木糖甙

Lyoniside

	产品编号	CFN98451
	CAS编号	34425-25-7
	分子式 = 分子量	C₂₇H₃₆O₁₂ = 552.6
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Lignans
	植物来源	The stem barks of Canarium bengalense
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
南烛木糖甙	CFN98451	34425-25-7	1mg	QQ客服：215959384
南烛木糖甙	CFN98451	34425-25-7	5mg	QQ客服：215959384
南烛木糖甙	CFN98451	34425-25-7	10mg	QQ客服：215959384
南烛木糖甙	CFN98451	34425-25-7	20mg	QQ客服：215959384

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

Description:

Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes, they demonstrate strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis, suggests that these two compounds potential anti-leishmanial candidates. The synergistic action of lyoniside and triterpene acids was demonstrated in inhibitory effect exerted on germination and growth of Pinus sylvestris.

Targets:

Antifection

In vitro:

Phytochem. Lett., 2011, 4(2):138-43.

Isolation and biological activities of lyoniside from rhizomes and stems of Vaccinium myrtillus.[Reference: WebLink]

A lignan glycoside identified as Lyoniside (9-O-β-d-xylopyranosyl(+)lyoniresinol) was obtained from ethanol extracts of the rhizomes and stems of bilberry (Vaccinium myrtillus L.), on a preparative scale, by droplet counter-current chromatography. The application of this method permitted the isolation of a pure substance in only one chromatographical step.
METHODS AND RESULTS:
The occurrence of Lyoniside in bilberry is reported for the first time. Seasonal fluctuations in the content of this compound in plant organs were demonstrated showing its highest levels in bilberry rhizomes and stems during the winter and their subsequent decrease in the spring. In vitro, the purified Lyoniside was evaluated for antioxidant, allelopathic and antifungal activities. It showed significant radical scavenging properties in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay with IC50 of 23 μg ml−1. Applied at concentration of 10 μg ml−1, it suppressed by 75% the seedling radical growth of Lactuca sativa and Lepidium sativum, and exerted strong inhibitory effect (55%) on germination of Larix decidua. Moreover, the synergistic action of Lyoniside and triterpene acids was demonstrated in inhibitory effect exerted on germination and growth of Pinus sylvestris.
CONCLUSIONS:
Among 5 tested fungi strains of Ascomycota, the highest susceptibility was shown by Fusarium oxysporum and Mucor hiemalis, with mycelial growth inhibited by Lyoniside concentration of 50 μg ml−1 by 78 and 80%, respectively.

In vivo:

Biochem Pharmacol. 2013 Dec 15;86(12):1673-87.

The lignan glycosides lyoniside and saracoside poison the unusual type IB topoisomerase of Leishmania donovani and kill the parasite both in vitro and in vivo.[Pubmed: 24134912]

Lignans are diphenyl propanoids with vast range of biological activities. The present study provides an important insight into the anti-leishmanial activities of two lignan glycosides, viz. Lyoniside and saracoside.
METHODS AND RESULTS:
These compounds inhibit catalytic activities of topoisomerase IB (LdTopIB) of Leishmania donovani in non-competitive manner and stabilize the LdTopIB mediated cleavage complex formation both in vitro and in Leishmania promastigotes and subsequently inhibit the religation of cleaved strand. These two compounds not only poison LdTopIB but also can interact with the free enzyme LdTopIB. We have also shown that Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes. The protein-DNA complex formation leads to double strand breaks in DNA which ultimately triggers apoptosis-like cell death in the parasite. Along with their cytotoxicity towards sodium antimony gluconate (SAG) sensitive AG83 strain, their ability to kill SAG resistant GE1 strain makes these two compounds potential anti-leishmanial candidates. Not only they effectively kill L. donovani amastigotes inside macrophages in vitro, Lyoniside and saracoside demonstrated strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis. Treatment with these lignan glycosides produce nitric oxide and reactive oxygen species which result in almost complete clearance of the liver and splenic parasite burden. These compounds do not inhibit human topoisomerase IB upto 200μM concentrations and had poor cytotoxic effect on uninfected cultured murine peritoneal macrophages upto 100μM concentrations.
CONCLUSIONS:
Taken together it can be concluded that these compounds can be developed into excellent therapeutic agent against deadly disease leishmaniasis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
异落叶松脂素; Isolariciresinol	CFN98915	548-29-8	C₂₀H₂₄O₆ = 360.4	5mg	QQ客服：3257982914
9,9'-O-Isopropyllidene-isolariciresinol; 9,9'-O-Isopropyllidene-isolariciresinol	CFN98276	252333-71-4	C₂₃H₂₈O₆ = 400.5	5mg	QQ客服：1413575084
异落叶松脂素 9'-beta-D-吡喃木糖苷; Schizandriside	CFN96693	71222-06-5	C₂₅H₃₂O₁₀ = 492.52	5mg	QQ客服：1457312923
(-)-异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-Isolariciresinol 9'-O-glucoside	CFN89431	143236-04-8	C₂₆H₃₄O₁₁ = 522.54	5mg	QQ客服：2159513211
Vitexdoin A; Vitexdoin A	CFN96194	1186021-77-1	C₁₉H₁₈O₆ = 342.4	5mg	QQ客服：2159513211
7,8,9,9-四脱氢异落叶松树脂酚; 7,8,9,9-Tetradehydroisolariciresinol	CFN99605	145918-59-8	C₂₀H₂₀O₆ = 356.4	5mg	QQ客服：2056216494
Vitedoin A; Vitedoin A	CFN96448	819861-40-0	C₂₀H₂₀O₆ = 356.37	5mg	QQ客服：3257982914
(-)-5'-甲氧基异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-5'-Methoxyisolariciresinol 3alpha-O-beta-glucopyranoside	CFN95403	143236-03-7	C₂₇H₃₆O₁₂ = 552.6	5mg	QQ客服：215959384
(+)-南烛木树脂酚; (+)-Lyoniresinol	CFN99488	14464-90-5	C₂₂H₂₈O₈ = 420.5	5mg	QQ客服：2056216494
南烛木糖甙; Lyoniside	CFN98451	34425-25-7	C₂₇H₃₆O₁₂ = 552.6	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8096 mL	9.0481 mL	18.0963 mL	36.1925 mL	45.2407 mL
5 mM	0.3619 mL	1.8096 mL	3.6193 mL	7.2385 mL	9.0481 mL
10 mM	0.181 mL	0.9048 mL	1.8096 mL	3.6193 mL	4.5241 mL
50 mM	0.0362 mL	0.181 mL	0.3619 mL	0.7239 mL	0.9048 mL
100 mM	0.0181 mL	0.0905 mL	0.181 mL	0.3619 mL	0.4524 mL

南烛木糖甙

Lyoniside

信息支持

联系方式