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    Nudiposide

    Nudiposide

    Nudiposide
    产品编号 CFN89146
    CAS编号 62058-46-2
    分子式 = 分子量 C27H36O12 = 552.57
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The stem barks of Saraca indica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Nudiposide CFN89146 62058-46-2 1mg QQ客服:2932563308
    Nudiposide CFN89146 62058-46-2 5mg QQ客服:2932563308
    Nudiposide CFN89146 62058-46-2 10mg QQ客服:2932563308
    Nudiposide CFN89146 62058-46-2 20mg QQ客服:2932563308
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    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University (Australia)
  • University of Stirling (United Kingdom)
  • Universidad Veracuzana (Mexico)
  • Utah State University (USA)
  • University of Canterbury (New Zealand)
  • Charles University in Prague (Czech Republic)
  • Istanbul University (Turkey)
  • Monash University Malaysia (Malaysia)
  • Utrecht University (Netherlands)
  • Shanghai Institute of Organic Chemistry (China)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • University of Perugia (Italy)
  • Ain Shams University (Egypt)
  • The Institute of Cancer Research (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tumour Biol.2015, 36(9):7027-34
  • Inflammation2015, 38(1):445-55
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Braz J Med Biol Res. 2016, 49(7)
  • Biochem Systematics and Ecology2017, 11-18
  • Int J Mol Sci.2017, 18(5)
  • University of Central Lancashire2017, 20472
  • Sci Rep.2017, 7:467-479
  • Microchemical Journal2018, 137:168-173
  • Phytother Res.2018, 32(5):923-932
  • Anticancer Res.2018, 38(4):2127-2135
  • J Sep Sci.2018, 41(7):1682-1690
  • Toxicol In Vitro.2018, 52:94-105
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Molecules.2019, 24(2):329
  • Molecules.2019, 24(24):E4536
  • J Funct Foods2019, 54:449-456
  • Phytomedicine.2019, 56:48-56
  • Int Immunopharmacol.2019, 71:22-31
  • Metabolites.2019, 9(11):E271
  • Nutrients.2020, 12(12):3638.
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • Pharmacol Rep.2020, 72(2):472-480.
  • ...
  • 生物活性
    Description: Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis in a mouse model and can decrease the plasma levels of TNF-α, IL-10 and ALT activity.
    Targets: TNF-α | IL Receptor | ALT
    In vitro:
    Pharmacogn Mag. 2015 Oct;11(Suppl 2):S303-7.
    Neuroprotective compounds of Tilia amurensis.[Pubmed: 26664019]
    In this study, we isolated five compounds from T. amurensis and determined whether protected neuronal cells against glutamate-induced oxidative stress in HT22 cells.
    METHODS AND RESULTS:
    Compounds were isolated using chromatographic techniques including silica gel, Sephadex LH-20 open column and high performance liquid chromatography analysis, and evaluated neuroprotective effect in HT22 cells by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. RESULTS: β-D-fructofuranosyl α-D-glucopyranoside (1), (-)-epicatechin (2), Nudiposide (3), lyoniside (4), and scopoletin (5) were isolated by bioactivity-guided fractionation from the ethyl acetate fraction of T. amurensis. Among them, (-)-epicatechin, Nudiposide, lyoniside, and scopoletin had significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells.
    CONCLUSIONS:
    These results demonstrated that compound two, three, four, and five have a pronounced protective effect against glutamate-induced neurotoxicity in HT22 cells.
    In vivo:
    Arch Pharm Res. 2011 Sep;34(9):1443-50.
    Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica.[Pubmed: 21975805 ]

    METHODS AND RESULTS:
    In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (-)-catechin (1), catechin-7-O-β-apiofuranoside (2), catechin-7-O-α-Lrhamnopyranoside (3), catechin-3-O-α-L-rhamnopyranoside (4), catechin-7-O-β-D-glucopyranoside (5), butyl (+)-5'-methoxyisolariciresinol-9'-O-β-D-xylopyranoside (6), lyoniside (7), Nudiposide (8), α-nigerose (9), butyl α-D-fructofuranoside (10), and procyanidin B(3) (11) were isolated from the root barks of Ulmus davidiana var. japonica.
    CONCLUSIONS:
    Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/D-GalN ranged from 80%-100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-α, IL-10 and ALT activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8097 mL 9.0486 mL 18.0973 mL 36.1945 mL 45.2431 mL
    5 mM 0.3619 mL 1.8097 mL 3.6195 mL 7.2389 mL 9.0486 mL
    10 mM 0.181 mL 0.9049 mL 1.8097 mL 3.6195 mL 4.5243 mL
    50 mM 0.0362 mL 0.181 mL 0.3619 mL 0.7239 mL 0.9049 mL
    100 mM 0.0181 mL 0.0905 mL 0.181 mL 0.3619 mL 0.4524 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (-)-异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-Isolariciresinol 9'-O-glucoside CFN89431 143236-04-8 C26H34O11 = 522.54 5mg QQ客服:3257982914
    Vitexdoin A; Vitexdoin A CFN96194 1186021-77-1 C19H18O6 = 342.4 5mg QQ客服:2159513211
    7,8,9,9-四脱氢异落叶松树脂酚; 7,8,9,9-Tetradehydroisolariciresinol CFN99605 145918-59-8 C20H20O6 = 356.4 5mg QQ客服:2056216494
    Vitedoin A; Vitedoin A CFN96448 819861-40-0 C20H20O6 = 356.37 5mg QQ客服:1457312923
    (+)-南烛木树脂酚; (+)-Lyoniresinol CFN99488 14464-90-5 C22H28O8 = 420.5 5mg QQ客服:2932563308
    南烛木糖甙; Lyoniside CFN98451 34425-25-7 C27H36O12 = 552.6 5mg QQ客服:2159513211
    (+)-南烛木树脂酚9'-O-葡萄糖甙; (+)-Lyoniresinol 9'-O-glucoside CFN97964 87585-32-8 C28H38O13 = 582.6 5mg QQ客服:2159513211
    (-)-Lyoniresinol 9'-O-glucoside ; (-)-Lyoniresinol 9'-O-glucoside CFN96732 143236-02-6 C28H38O13 = 582.59 5mg QQ客服:2159513211
    Nudiposide; Nudiposide CFN89146 62058-46-2 C27H36O12 = 552.57 5mg QQ客服:2159513211
    异紫杉脂素9,9'-缩丙酮; Isotaxiresinol 9,9'-acetonide CFN97774 252333-72-5 C22H26O6 = 386.44 5mg QQ客服:2056216494

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