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    产品编号 CFN97234
    CAS编号 75590-33-9
    分子式 = 分子量 C21H20O6 = 368.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Bupleurum chinense DC.
    产品名称 产品编号 CAS编号 包装 QQ客服
    Kaerophyllin CFN97234 75590-33-9 1mg QQ客服:215959384
    Kaerophyllin CFN97234 75590-33-9 5mg QQ客服:215959384
    Kaerophyllin CFN97234 75590-33-9 10mg QQ客服:215959384
    Kaerophyllin CFN97234 75590-33-9 20mg QQ客服:215959384
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • 生物活性
    Description: Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting HSC activation, possibly through upregulation of PPAR-γ expression. Kaerophyllin inhibits AB-induced LX-2 activation and migration with downregulation of Akt/ERK phosphorylations and NF-κB activity.
    Targets: TNF-α | PPAR | Akt | ERK | NF-kB | IL Receptor
    In vitro:
    Liver Int. 2011 May;31(5):618-29.
    Kaerophyllin inhibits hepatic stellate cell activation by apoptotic bodies from hepatocytes.[Pubmed: 21457435]
    Hepatic stellate cells (HSCs), the key cell type for hepatic fibrosis, become activated and profibrogenic in the presence of hepatocyte apoptotic bodies (ABs). Bupleurum scorzonerifolium (BS), a widely used traditional Chinese herb for liver diseases, was fractionated, and the inhibitory effects of BS extracts on AB-induced HSC migration were screened. The activity-guided fractionation led to a lignan, Kaerophyllin. In this study, the anti-fibrotic effects of Kaerophyllin were studied in the presence of ABs.
    LX-2 cells phagocytosing ultraviolet (UV)-induced HepG2 ABs were investigated by confocal microscopy and flow cytometry. AB-induced HSC activation was evaluated by immunoblotting and real-time PCR analyses. HSC migration was measured by wound-healing assays. HepG2 ABs induced LX-2 activation, with the production of collagen I and α-smooth muscle actin, upregulated profibrogenic gene transcriptions and increased NF-κB activity, cell migration and phagocytosis. Kaerophyllin from BS antagonized AB-induced HSC migration and activation.
    Kaerophyllin inhibited AB-induced LX-2 activation and migration with downregulation of Akt/ERK phosphorylations and NF-κB activity. Our study suggests a novel platform for screening anti-fibrotic compounds with ABs.
    In vivo:
    Planta Med. 2011, 77(12):1410-1410.
    Kaerophyllin Suppresses Hepatic Stellate Cell Activation by Apoptotic Bodies and Ameliorates Hepatic Fibrosis in Rats.[Reference: WebLink]
    Hepatocyte apoptosis is a central feature of many liver diseases, leading to liver inflammation and fibrosis. In this study, we screened potential drugs inhibiting hepatic stellate cell (HSC) migration induced by hepatocyte apoptotic bodies (ABs) and evaluated the in vivo therapeutic effects in a rat model of hepatic fibrosis induced by thioacetamide (TAA).
    Rat HSCs were exposed to UV-irradiated hepatocyte ABs or TNF-α to investigate the anti-fibrotic effects of Kaerophyllin. Liver fibrosis was induced by TAA injection into rats twice weekly for 6 weeks. Kaerophyllin (10 or 30mg/kg) or curcumin (150mg/kg, as a positive control) was given by gavage twice daily for 4 weeks starting 2 weeks after TAA injection. Kaerophyllin (α-(trans-3,4-dimethoxybenzylidene)-β-(3,4-methylenedioxy-benzyl)-γ-butyrolactone, a lignan isolated from a Chinese herb Bupleurum scorzonerifolium by bioactivity-guided fractionation) attenuated ABs- and TNF-α-induced HSC migration, protein levels of collagen I and α-SMA, and the mRNA levels of ICAM-1, MCP-1 and IL-1β genes, but elevated PPAR-γ luciferase activity. Furthermore, Kaerophyllin reduced TNF-α- and ABs-induced NF-κB luciferase activity with decreased IκB phosphorylation and p65 nuclear translocation. In TAA rats, Kaerophyllin and curcumin treatment significantly protected liver from injury by reducing serum AST and ALT levels, and improved the histological architecture and fibrosis score. In addition, Kaerophyllin treatment suppressed α-SMA protein expression, and mRNA levels of collagen I, TIMP-1, TNF-α, IL-1β and MCP-1 genes in TAA rats.
    Our results demonstrated that Kaerophyllin protected the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting HSC activation.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7144 mL 13.5722 mL 27.1444 mL 54.2888 mL 67.861 mL
    5 mM 0.5429 mL 2.7144 mL 5.4289 mL 10.8578 mL 13.5722 mL
    10 mM 0.2714 mL 1.3572 mL 2.7144 mL 5.4289 mL 6.7861 mL
    50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0858 mL 1.3572 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Styraxlignolide F; Styraxlignolide F CFN92491 823214-06-8 C27H34O11 = 534.6 5mg QQ客服:215959384
    甲基牛蒡酚, 甲基牛蒡子素; 2,3-Bis(3,4-dimethoxybenzyl)butyrolactone CFN98281 25488-59-9 C22H26O6 = 386.4 5mg QQ客服:1413575084
    Tupichilignan A; Tupichilignan A CFN97182 69586-96-5 C22H26O7 = 402.4 5mg QQ客服:1413575084
    5-乙酰氧基罗汉松脂酚二甲醚; 5-Acetoxymatairesinol dimethyl ether CFN97230 74892-45-8 C24H28O8 = 444.5 5mg QQ客服:3257982914
    Pluviatolide; Pluviatolide CFN92059 28115-68-6 C20H20O6 = 356.4 5mg QQ客服:1148253675
    Kaerophyllin; Kaerophyllin CFN97234 75590-33-9 C21H20O6 = 368.4 5mg QQ客服:3257982914
    Meridinol; Meridinol CFN99313 120051-54-9 C20H18O7 = 370.4 5mg QQ客服:1413575084
    桧脂素, 洒维宁; Savinin CFN98786 493-95-8 C20H16O6 = 352.3 5mg QQ客服:215959384
    苏齐内酯; Suchilactone CFN95010 50816-74-5 C21H20O6 = 368.4 5mg QQ客服:2159513211
    (E)-alpha-(3,4-Methylenedioxybenzylidene)-beta-(3,4,5-trimethoxybenzyl)-gamma-butyrolactone; Isonemerosin CFN95008 181524-79-8 C22H22O7 = 398.4 20mg QQ客服:215959384





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