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  • 络石苷

    Tracheloside

    络石苷
    产品编号 CFN90597
    CAS编号 33464-71-0
    分子式 = 分子量 C27H34O12 = 550.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herbs of Trachelospermum jasminoides (Lindl.) Lem.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    络石苷 CFN90597 33464-71-0 10mg QQ客服:1148253675
    络石苷 CFN90597 33464-71-0 20mg QQ客服:1148253675
    络石苷 CFN90597 33464-71-0 50mg QQ客服:1148253675
    络石苷 CFN90597 33464-71-0 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Vienna (Austria)
  • Tohoku University (Japan)
  • The University of Newcastle (Australia)
  • Ateneo de Manila University (Philippines)
  • Washington State University (USA)
  • Donald Danforth Plant Science Center (USA)
  • University of Oslo (Norway)
  • Universit?t Basel (Switzerland)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Chang Gung University (Taiwan)
  • University of Beira Interior (Portugal)
  • Srinakharinwirot University (Thailand)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • CSIRO - Agriculture Flagship (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2015, 12(5):7789-95
  • Mol Cells.2015, 38(9):765-72
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • Universidade Estadual Paulista2017, 11449
  • Plant Methods.2017, 13:108
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Biol Pharm Bull.2017, 40(6):797-806
  • Aquaculture2017, 481:94-102
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Nat Prod Sci.2018, 24(2):109-114
  • Industrial Crops and Products2018, 353-362
  • Sci Rep. 2018, 462(8)
  • Planta Med.2018, 84(15):1101-1109
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Int J Mol Sci.2019, 20(23):E6071
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Molecules.2019, 24(12):E2286
  • Chem Biol Interact.2019, 298:1-7
  • FASEB J.2019, 33(8):9685-9694
  • Srinagarind Medical Journal2019, 34(1)
  • Phytomedicine.2019, 62:152962
  • J Cell Physiol.2020, 10.1002
  • ...
  • 生物活性
    Description: Tracheloside significantly decreases the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC(50) value of 0.31 microg/ml, a level of inhibition comparable to that of tamoxifen (IC(50) = 0.43 microg/ml).
    Targets: Estrogen receptor | Progestogen receptor
    In vitro:
    Biosci Biotechnol Biochem. 2006 Nov;70(11):2783-5.
    An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius.[Pubmed: 17090940]
    The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method.
    METHODS AND RESULTS:
    Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC(50) value of 0.31 microg/ml, a level of inhibition comparable to that of tamoxifen (IC(50) = 0.43 microg/ml).
    In vivo:
    Cancer Lett. 2003 Oct 28;200(2):133-9.
    Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.[Pubmed: 14568166]
    Tracheloside, one of the plant lignans which can be extracted from the debris after safflower oil is produced from the seeds of Carthamus tinctorious, is an analogue of another plant lignan, arctiin, the side-chain C-2 of the five-membered ring being changed from a hydrogen to a hydroxyl group. We have already demonstrated that arctiin has chemopreventive effect on mammary carcinogenesis. Therefore, chemopreventive effects of tracheloside on the initiation or post-initiation period of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female rats were examined.
    METHODS AND RESULTS:
    For initiation, female Sprague-Dawley (SD) rats at the 6 weeks of age were given intragastric administrations of 100 mg/kg body weight of PhIP once a week for 8 weeks. The animals were treated with 0.2 or 0.02% tracheloside during or after this carcinogen exposure. Control rats were fed basal diet with PhIP initiation or 0.2% tracheloside or basal diet alone without initiation throughout the experimental period. All surviving animals were necropsied at the week 52 of administration. There were no clear treatment-related changes with statistical significance in all parameters for mammary carcinomas measured in this experiment.
    CONCLUSIONS:
    These results indicate that tracheloside may not exert significant effects on PhIP-induced mammary carcinogenesis at least under the present experiment condition.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8175 mL 9.0876 mL 18.1752 mL 36.3504 mL 45.438 mL
    5 mM 0.3635 mL 1.8175 mL 3.635 mL 7.2701 mL 9.0876 mL
    10 mM 0.1818 mL 0.9088 mL 1.8175 mL 3.635 mL 4.5438 mL
    50 mM 0.0364 mL 0.1818 mL 0.3635 mL 0.727 mL 0.9088 mL
    100 mM 0.0182 mL 0.0909 mL 0.1818 mL 0.3635 mL 0.4544 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甲基牛蒡酚, 甲基牛蒡子素; 2,3-Bis(3,4-dimethoxybenzyl)butyrolactone CFN98281 25488-59-9 C22H26O6 = 386.4 5mg QQ客服:2932563308
    Tupichilignan A; Tupichilignan A CFN97182 69586-96-5 C22H26O7 = 402.4 5mg QQ客服:3257982914
    5-乙酰氧基罗汉松脂酚二甲醚; 5-Acetoxymatairesinol dimethyl ether CFN97230 74892-45-8 C24H28O8 = 444.5 5mg QQ客服:1413575084
    Pluviatolide; Pluviatolide CFN92059 28115-68-6 C20H20O6 = 356.4 5mg QQ客服:1413575084
    Kaerophyllin; Kaerophyllin CFN97234 75590-33-9 C21H20O6 = 368.4 5mg QQ客服:2159513211
    Meridinol; Meridinol CFN99313 120051-54-9 C20H18O7 = 370.4 5mg QQ客服:1148253675
    桧脂素, 洒维宁; Savinin CFN98786 493-95-8 C20H16O6 = 352.3 5mg QQ客服:3257982914
    苏齐内酯; Suchilactone CFN95010 50816-74-5 C21H20O6 = 368.4 5mg QQ客服:215959384
    (E)-alpha-(3,4-Methylenedioxybenzylidene)-beta-(3,4,5-trimethoxybenzyl)-gamma-butyrolactone; Isonemerosin CFN95008 181524-79-8 C22H22O7 = 398.4 20mg QQ客服:215959384
    2,3-双(3,4-亚甲基二氧基苄基)丁-2-烯-4-内酯; 2,3-Di(3',4'-methylenedioxybenzyl)-2-buten-4-olide CFN97895 137809-97-3 C20H16O6 = 352.3 5mg QQ客服:2932563308

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