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  • 棕矢车菊素

    Jaceosidin

    棕矢车菊素
    产品编号 CFN90386
    CAS编号 18085-97-7
    分子式 = 分子量 C17H14O7 = 330.29
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Artemisia arctica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    棕矢车菊素 CFN90386 18085-97-7 10mg QQ客服:3257982914
    棕矢车菊素 CFN90386 18085-97-7 20mg QQ客服:3257982914
    棕矢车菊素 CFN90386 18085-97-7 50mg QQ客服:3257982914
    棕矢车菊素 CFN90386 18085-97-7 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Weizmann Institute of Science (Israel)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • University of Oslo (Norway)
  • University of Indonesia (Indonesia)
  • Universidad Industrial de Santander (Colombia)
  • University of the Basque Country (Spain)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Cornell University (USA)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University Medical Center Mainz (Germany)
  • University of Leipzig (Germany)
  • University of Bonn (Germany)
  • The University of Newcastle (Australia)
  • University of Toulouse (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Inflammation.2015, 38(4):1502-16
  • Mol Cells.2015, 38(9):765-72
  • Chem Biol Interact.2016, 258:59-68
  • Research on Crops.2017, 18(3):569
  • Exp Parasitol.2017, 183:160-166
  • J Ethnopharmacol.2017, 206:327-336
  • Arch Toxicol.2017, 91(10):3225-3245
  • Front Aging Neurosci.2018, 10:269
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • J Hematol Oncol.2018, 11(1):112
  • International Food Research Journal2018, 25(6):2560-2571
  • Pak J Pharm Sci.2018, 31:311-315
  • Korean J Environ Agric.2018, 37(4):260-267
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Front Cell Infect Microbiol.2018, 8:292
  • Nat Commun.2019, 10(1):2745
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • J Ethnopharmacol.2019, 228:132-141
  • Food Engineering Progress2019, 23(3)209-216
  • Molecules.2019, 24(9):E1719
  • Phytother Res.2019, 33(4):1104-1113
  • Plant Foods Hum Nutr.2020, 10.1007
  • ...
  • 生物活性
    Description: Jaceosidin has immunosuppressive, anti-oxidative, anti-inflammatory, and anticancer activities, it is also a microglial inhibitor with anti-neuroinflammation activity. Jaceosidin modulates the ERK/ATM/Chk1/2 pathway, leading to inactivation of the Cdc2-cyclin B1 complex, followed by G2/M cell cycle arrest in endometrial cancer cells. Jaceosidin inhibits T cell proliferation and activation, which is closely associated with its potent down-regulation of the IFN-γ/STAT1/T-bet signaling pathway.
    Targets: VEGFR | FAK | PI3K | Akt | NF-kB | p21 | Chk | ATM/ATR | NO | P450 (e.g. CYP17) | IFN-γ | IL Receptor | STAT | TNF-α
    In vitro:
    Food Chem Toxicol. 2013 May;55:214-21.
    Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation.[Pubmed: 23274058]
    Jaceosidin, a flavonoid derived from Artemisia princeps (Japanese mugwort), has been shown to inhibit the growth of several human cancer cells, However, the exact mechanism for the cytotoxic effect of jaceosidin is not completely understood.
    METHODS AND RESULTS:
    In this study, we investigated the molecular mechanism involved in the antiproliferative effect of jaceosidin in human endometrial cancer cells. We demonstrated that jaceosidin is a more potent inhibitor of cell growth than cisplatin in human endometrial cancer cells. In contrast, jaceosidin-induced cytotoxicity in normal endometrial cells was lower than that observed for cisplatin. Jaceosidin induced G2/M phase cell cycle arrest and modulated the levels of cyclin B and p-Cdc2 in Hec1A cells. Knockdown of p21 using specific siRNAs partially abrogated jaceosidin-induced cell growth inhibition. Additional mechanistic studies revealed that jaceosidin treatment resulted in an increase in phosphorylation of Cdc25C and ATM-Chk1/2. Ku55933, an ATM inhibitor, reversed jaceosidin-induced cell growth inhibition, in part. Moreover, jaceosidin treatment resulted in phosphorylation of ERK, and pretreatment with the ERK inhibitor, PD98059, attenuated cell growth inhibition by jaceosidin.
    CONCLUSIONS:
    These data suggest that jaceosidin, isolated from Japanese mugwort, modulates the ERK/ATM/Chk1/2 pathway, leading to inactivation of the Cdc2-cyclin B1 complex, followed by G2/M cell cycle arrest in endometrial cancer cells.
    In vivo:
    Phytother Res. 2013 Mar;27(3):404-11.
    Natural flavone jaceosidin is a neuroinflammation inhibitor.[Pubmed: 22619052]
    Jaceosidin is a naturally occurring flavone with pharmacological activity. Jaceosidin, as one of the major constituents of the medicinal herbs of the genus Artemisia, has been shown to exert anticancer, anti-oxidative, anti-inflammatory, and immunosuppressive effects. This study was undertaken to determine the effect of jaceosidin on microglia and neuroinflammation.
    METHODS AND RESULTS:
    Microglia are the innate immune cells in the central nervous system, and they play a central role in the initiation and maintenance of neuroinflammation. We report that jaceosidin inhibits inflammatory activation of microglia, reducing nitric oxide (NO) production and proinflammatory cytokine expression. IC50 for NO inhibition was 27 ± 0.4 μM. The flavone also attenuated microglial neurotoxicity in the microglia/neuroblastoma co-culture. Systemic injection of jaceosidin ameliorated neuroinflammation in the mouse model of experimental allergic encephalomyelitis.
    CONCLUSIONS:
    These results indicate that plant flavone jaceosidin is a microglial inhibitor with anti-neuroinflammation activity.
    Eur J Pharmacol. 2011 Jan 25;651(1-3):205-11.
    Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells.[Pubmed: 21093428]
    In the present study, we aimed to investigate the immunosuppressive activity of jaceosidin, a flavone isolated from Artemisia vestita, on T lymphocytes both in vitro and in vivo, and further explore its potential molecular mechanism.
    METHODS AND RESULTS:
    Jaceosidin exerted a significant inhibition on the T cell proliferation and activation induced by concanavalin A (Con A) in a concentration-dependent manner and it also inhibited the secretion of the proinflammatory cytokines such as IL-2, TNF-α and IFN-γ of activated T cells. Further study showed that jaceosidin down-regulated STAT1 activation and T-bet expression in activated T cells. Moreover, in order to investigate the immunosuppressive effect of jaceosidin in vivo, the picryl chloride (PCl)-induced ear contact dermatitis model was performed on BALB/c mice. Jaceosidin significantly ameliorated PCl-induced ear swelling in a dose-dependent manner, which was due to its inhibition of the STAT1/T-bet signaling pathway.
    CONCLUSIONS:
    In summary, these findings suggest that jaceosidin exerts its immunosuppressive effect both in vitro and in vivo through inhibiting T cell proliferation and activation, which is closely associated with its potent down-regulation of the IFN-γ/STAT1/T-bet signaling pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0276 mL 15.1382 mL 30.2764 mL 60.5528 mL 75.6911 mL
    5 mM 0.6055 mL 3.0276 mL 6.0553 mL 12.1106 mL 15.1382 mL
    10 mM 0.3028 mL 1.5138 mL 3.0276 mL 6.0553 mL 7.5691 mL
    50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.2111 mL 1.5138 mL
    100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,6,3',4'-四羟基-7-甲氧基黄酮; Pedalitin CFN96045 22384-63-0 C16H12O7 = 316.3 5mg QQ客服:2159513211
    泽兰黄酮; 6-甲氧基藤黄菌素; 6-Methoxyluteolin CFN92706 520-11-6 C16H12O7 = 316.3 10mg QQ客服:2159513211
    条叶蓟素; Cirsiliol CFN96508 34334-69-5 C17H14O7 = 330.29 5mg QQ客服:1148253675
    Leucanthogenin; Leucanthogenin CFN92953 99615-00-6 C17H14O8 = 346.29 5mg QQ客服:215959384
    毒马草黄酮; Sideritoflavone CFN96399 70360-12-2 C18H16O8 = 360.3 5mg QQ客服:1413575084
    栀子黄素D; Gardenin D CFN95133 29202-00-4 C19H18O8 = 374.4 5mg QQ客服:1148253675
    香叶木素; Diosmetin CFN90210 520-34-3 C16H12O6 = 300.26 20mg QQ客服:2932563308
    Pilloin; Pilloin CFN96503 32174-62-2 C17H14O6 = 314.29 10mg QQ客服:215959384
    去甲氧基矢车菊黄酮素; Desmethoxycentaureidin CFN98234 22934-99-2 C17H14O7 = 330.3 5mg QQ客服:215959384
    半齿泽兰素; Eupatorin CFN97418 855-96-9 C18H16O7 = 344.3 10mg QQ客服:3257982914

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