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  • 泽兰黄酮; 6-甲氧基藤黄菌素

    6-Methoxyluteolin

    泽兰黄酮; 6-甲氧基藤黄菌素
    产品编号 CFN92706
    CAS编号 520-11-6
    分子式 = 分子量 C16H12O7 = 316.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The flowers of Chrysanthemum zawadskii var. latilobum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    泽兰黄酮; 6-甲氧基藤黄菌素 CFN92706 520-11-6 10mg QQ客服:1413575084
    泽兰黄酮; 6-甲氧基藤黄菌素 CFN92706 520-11-6 20mg QQ客服:1413575084
    泽兰黄酮; 6-甲氧基藤黄菌素 CFN92706 520-11-6 50mg QQ客服:1413575084
    泽兰黄酮; 6-甲氧基藤黄菌素 CFN92706 520-11-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Virginia (USA)
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  • University Medical Center Mainz (Germany)
  • University of Hull (United Kingdom)
  • Siksha O Anusandhan University (India)
  • University of Illinois (USA)
  • Universidad Miguel Hernández (Spain)
  • Universidad Veracuzana (Mexico)
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  • Regional Crop Research Institute (Korea)
  • University of Dicle (Turkey)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Separations2023, 10(11), 567;
  • Microb Biotechnol.2021, 14(5):2009-2024.
  • Anesth Pain Med (Seoul).2020, 15(4):478-485.
  • Reprod Sci.2022,10.1007/s43032-022-01117-4.
  • Tissue Cell.2022, 75:101728.
  • Pharm Biol.2021, 59(1):134-145.
  • Int J Mol Sci.2019, 20(9):E2244
  • Environ Toxicol.2020, doi: 10.1002
  • Agronomy2023, 13(6), 1435.
  • Front Pharmacol.2022, 13:919230.
  • Food Chem Toxicol.2023, 176:113802.
  • Pharm Biol.2017, 55(1):360-366
  • Cell Prolif.2021, 54(8):e13083.
  • Biol Pharm Bull.2018, 41(1):65-72
  • Plants (Basel).2022, 11(21):2947.
  • Food Control2022, 132:108434.
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • Kasetsart University2022, ethesis.1144.
  • Int J Oncol.2019, 55(1):320-330
  • Spectrochim Acta A2019, 210:372-380
  • APMIS.2019, 127(10):688-695
  • Pharm Biol.2022, 60(1):2040-2048.
  • Biomed Pharmacother.2021, 144:112300.
  • ...
  • 生物活性
    Description: 6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
    Targets: Calcium Channel | Histamine Receptor
    In vitro:
    J Microbiol Biotechnol. 2012 May;22(5):622-7.
    6-Methoxyluteolin from Chrysanthemum zawadskii var. latilobum suppresses histamine release and calcium influx via down-regulation of FcεRI α chain expression.[Pubmed: 22561855]
    Mast cells and basophils are important effector cells in immunoglobulin-E (IgE)-mediated allergic reactions.
    METHODS AND RESULTS:
    Using the human basophilic KU812F cells, we assessed the inhibitory effects of 6-methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcεRI-mediated allergic reaction. We determined that 6-methoxyluteolin inhibited anti-FcεRI α chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Moreover, the inhibitory effects of 6-methoxyluteolin on the cell surface expression and the mRNA level of the FcεRI α chain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR), respectively.
    CONCLUSIONS:
    Therefore, these results show that 6- methoxyluteolin is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
    Biomed Pharmacother . 2018 May;101:87-93.
    Nepetin inhibits IL-1β induced inflammation via NF-κB and MAPKs signaling pathways in ARPE-19 cells[Pubmed: 29477475]
    Abstract Backgrounds: Chronic inflammation in retinal pigment epithelial (RPE) cells is related to the pathogenesis of retinal inflammatory blind causing diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR). Nepetin, a natural flavonoid compound, has shown potent anti-inflammatory activities but has not been studied on ocular resident cells yet. Here, we assess the ability of Nepetin to alleviate the inflammatory responses of ARPE-19 cells induced by interleukin (IL)-1β. Methods: The secretion and mRNA expression of inflammatory cytokines IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1) induced by IL-1β are measured by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (RT-PCR) respectively. To clarify the underlying action mechanism, we examine the effect of Nepetin on activation of nuclear factor of kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways using Western blot. Results: Nepetin can significantly decrease the three inflammatory mediators at both protein and mRNA level in a dose-dependent manner. Western blot results show that Nepetin can decrease the nuclear translocation of p65 through suppressing phosphorylation of inhibitor of nuclear factor kappa B (IκB) and IκB kinase (IKK). Also, Nepetin can decrease the phosphorylation of extracellular signal-regulated kinases (ERK) 1/2, c-Jun N-terminal kinase (JNK) and p38 MAPK. Conclusions: Taken together, Nepetin abolishes IL-1β-induced IL-6, IL-8 and MCP-1 secretion and mRNA expression by repressing the activation of NF-κB and MAPKs. These results indicate that Nepetin shows potential to be used for prevention and treatment of inflammatory retinal diseases or as a lead compound. Keywords: ARPE-19; Inflammation; MAPK; NF-κB; Nepetin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1616 mL 15.8078 mL 31.6156 mL 63.2311 mL 79.0389 mL
    5 mM 0.6323 mL 3.1616 mL 6.3231 mL 12.6462 mL 15.8078 mL
    10 mM 0.3162 mL 1.5808 mL 3.1616 mL 6.3231 mL 7.9039 mL
    50 mM 0.0632 mL 0.3162 mL 0.6323 mL 1.2646 mL 1.5808 mL
    100 mM 0.0316 mL 0.1581 mL 0.3162 mL 0.6323 mL 0.7904 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    木犀草素; 3',4',5,7-四羟基黄酮; Luteolin CFN98784 491-70-3 C15H10O6 = 286.2 20mg QQ客服:1457312923
    羟基芫花素; Hydroxygenkwanin CFN98021 20243-59-8 C16H12O6 = 300.3 20mg QQ客服:2056216494
    5,7-二甲氧基木犀草素; 5,7-Dimethoxyluteolin CFN91001 N/A C17H14O6 = 314.3 10mg QQ客服:1413575084
    5,6,3',4'-四羟基-7-甲氧基黄酮; Pedalitin CFN96045 22384-63-0 C16H12O7 = 316.3 5mg QQ客服:1457312923
    泽兰黄酮; 6-甲氧基藤黄菌素; 6-Methoxyluteolin CFN92706 520-11-6 C16H12O7 = 316.3 20mg QQ客服:2056216494
    条叶蓟素; Cirsiliol CFN96508 34334-69-5 C17H14O7 = 330.29 5mg QQ客服:1457312923
    Leucanthogenin; Leucanthogenin CFN92953 99615-00-6 C17H14O8 = 346.29 5mg QQ客服:2159513211
    毒马草黄酮; Sideritoflavone CFN96399 70360-12-2 C18H16O8 = 360.3 5mg QQ客服:1413575084
    栀子黄素D; Gardenin D CFN95133 29202-00-4 C19H18O8 = 374.4 5mg QQ客服:1413575084
    香叶木素; Diosmetin CFN90210 520-34-3 C16H12O6 = 300.26 20mg QQ客服:1413575084

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