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  • 条叶蓟素

    Cirsiliol

    条叶蓟素
    产品编号 CFN96508
    CAS编号 34334-69-5
    分子式 = 分子量 C17H14O7 = 330.29
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The aerial parts of Phyla nodiflora.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    条叶蓟素 CFN96508 34334-69-5 1mg QQ客服:2159513211
    条叶蓟素 CFN96508 34334-69-5 5mg QQ客服:2159513211
    条叶蓟素 CFN96508 34334-69-5 10mg QQ客服:2159513211
    条叶蓟素 CFN96508 34334-69-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Wroclaw Medical University (Poland)
  • Universidad de La Salle (Mexico)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Uniwersytet Gdański (Poland)
  • University of Medicine and Pharmacy (Romania)
  • University of Malaya (Malaysia)
  • University of Bordeaux (France)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Florida A&M University (USA)
  • University of Limpopo (South Africa)
  • Kazusa DNA Research Institute (Japan)
  • Universitas islam negeri Jakarta (Indonesia)
  • The Institute of Cancer Research (United Kingdom)
  • Wageningen University (Netherlands)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Nat Prod.2015, 78(6):1339-4
  • Phytomedicine.2016, 23(4):331-9
  • Int J Mol Sci.2017, 18(12)
  • Biol Pharm Bull.2017, 40(6):797-806
  • Mol Pharm.2018, 15(8):3285-3296
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Korean J of Medicinal Crop Science2018, 220-226
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Primary and Industrial.2018, 52(11)
  • Arch Biochem Biophys.2018, 644:93-99
  • Bio-protocol2018, 9(14):e3301
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Nat Commun.2019, 10(1):2745
  • Cell Death Dis.2019, 10(12):882
  • Front Neurosci.2019, 13:1091
  • Int J Mol Sci.2019, 20(21):E5488
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • J Mol Histol.2019, 50(4):343-354
  • Plos One.2019, 15(2):e0220084
  • J Nat Prod.2019, 82(4):1002-1008
  • Process Biochemistry2019, 87:213-220
  • Food Research International2020, 108987
  • United States Patent Application2020, 20200038363
  • ...
  • 生物活性
    Description: Cirsiliol shows antioxidant, and anti-obesity effects, it can inhibit TG accumulation in 3T3-L1 preadipocytes. Cirsiliol and rhamnetin can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways.
    Targets: NO | NF-kB
    In vitro:
    J Nat Med. 2014 Apr;68(2):414-20.
    Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells.[Pubmed: 24142543 ]

    METHODS AND RESULTS:
    We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aerial part of A. scoparia Waldst. et Kit. along with 18 known compounds. The structure of the new chromane, scopariachromane (1), was elucidated by spectroscopic analyses. The inhibitory effects of the compounds on TG accumulation activity were examined. Among these, Cirsiliol (11) inhibited TG accumulation in 3T3-L1 preadipocytes. Jaceosidin (12) inhibited NO production in a murine macrophage-like cell line (RAW 264.7).
    CONCLUSIONS:
    These results indicate that the 80 % aqueous EtOH extract and compounds isolated from the aerial part of A. scoparia Waldst. et Kit. may improve obesity-related insulin resistance.
    J Biol Chem. 2013 Sep 20;288(38):27343-57.
    Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines.[Pubmed: 23902763 ]

    METHODS AND RESULTS:
    Treatment with rhamnetin or Cirsiliol reduced the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression. Indeed, rhamnetin and Cirsiliol increased the expression of tumor-suppressive microRNA, miR-34a, in a p53-dependent manner, leading to inhibition of Notch-1 expression. Consequently, reduced Notch-1 expression promoted apoptosis through significant down-regulation of the nuclear factor-κB pathway, resulting in a radiosensitizing effect on NSCLC cells. Irradiation-induced epithelial-mesenchymal transition was also notably attenuated in the presence of rhamnetin and Cirsiliol. Moreover, an in vivo xenograft mouse model confirmed the radiosensitizing and epithelial-mesenchymal transition inhibition effects of rhamnetin and Cirsiliol we observed in vitro. In these mice, tumor volume was significantly reduced by combinational treatment with irradiation and rhamnetin or Cirsiliol compared with irradiation alone.
    CONCLUSIONS:
    Taken together, our findings provided evidence that rhamnetin and Cirsiliol can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0276 mL 15.1382 mL 30.2764 mL 60.5528 mL 75.6911 mL
    5 mM 0.6055 mL 3.0276 mL 6.0553 mL 12.1106 mL 15.1382 mL
    10 mM 0.3028 mL 1.5138 mL 3.0276 mL 6.0553 mL 7.5691 mL
    50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.2111 mL 1.5138 mL
    100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,6,3',4'-四羟基-7-甲氧基黄酮; Pedalitin CFN96045 22384-63-0 C16H12O7 = 316.3 5mg QQ客服:1148253675
    泽兰黄酮; 6-甲氧基藤黄菌素; 6-Methoxyluteolin CFN92706 520-11-6 C16H12O7 = 316.3 10mg QQ客服:215959384
    条叶蓟素; Cirsiliol CFN96508 34334-69-5 C17H14O7 = 330.29 5mg QQ客服:215959384
    Leucanthogenin; Leucanthogenin CFN92953 99615-00-6 C17H14O8 = 346.29 5mg QQ客服:3257982914
    毒马草黄酮; Sideritoflavone CFN96399 70360-12-2 C18H16O8 = 360.3 5mg QQ客服:2159513211
    栀子黄素D; Gardenin D CFN95133 29202-00-4 C19H18O8 = 374.4 5mg QQ客服:215959384
    香叶木素; Diosmetin CFN90210 520-34-3 C16H12O6 = 300.26 20mg QQ客服:215959384
    Pilloin; Pilloin CFN96503 32174-62-2 C17H14O6 = 314.29 10mg QQ客服:1148253675
    去甲氧基矢车菊黄酮素; Desmethoxycentaureidin CFN98234 22934-99-2 C17H14O7 = 330.3 5mg QQ客服:2159513211
    半齿泽兰素; Eupatorin CFN97418 855-96-9 C18H16O7 = 344.3 10mg QQ客服:2159513211

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