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  • 异麦角甾苷

    Isoacteoside

    异麦角甾苷
    产品编号 CFN97049
    CAS编号 61303-13-7
    分子式 = 分子量 C29H36O15 = 624.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Pedicularis striata Pall.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    异麦角甾苷 CFN97049 61303-13-7 10mg QQ客服:2932563308
    异麦角甾苷 CFN97049 61303-13-7 20mg QQ客服:2932563308
    异麦角甾苷 CFN97049 61303-13-7 50mg QQ客服:2932563308
    异麦角甾苷 CFN97049 61303-13-7 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Institute of Chinese Materia Medica (China)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Kyushu University (Japan)
  • University of Padjajaran (Indonesia)
  • Mendel University in Brno (Czech Republic)
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  • Auburn University (USA)
  • The Institute of Cancer Research (United Kingdom)
  • University of Dicle (Turkey)
  • Utah State University (USA)
  • University of Malaya (Malaysia)
  • University of Liège (Belgium)
  • University of Sao Paulo (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Auburn University2015, 1-58
  • BMC Complement Altern Med.2016, 16:213
  • Mediators Inflamm.2016, 2016:7216912
  • Oncol Rep.2016, 35(3):1356-64
  • Biochem Systematics and Ecology2017, 11-18
  • J Ethnopharmacol.2017, 198:205-213
  • Journal of Functional Foods2017, 30:30-38
  • Plant Cell Tiss Org2017, 479-486
  • Oncotarget.2017, 9(3):4161-4172
  • Arch Toxicol.2017, 91(10):3225-3245
  • Int J Mol Sci.2018, 19(9):E2528
  • Exp Neurobiol.2018, 27(3):200-209
  • Phytomedicine.2018, 41:62-66
  • Sci Rep.2018, 8(1)
  • Planta Med.2018, 84(15):1101-1109
  • Front Pharmacol.2018, 9:236
  • Front Aging Neurosci.2019, 11:230
  • Cancer Manag Res.2019, 11:483-500
  • Mol Microbiol.2019, 112(1):317-332
  • J Pharm Biomed Anal.2019, 172:268-277
  • Molecules.2019, 24(10):E1926
  • Phytother Res.2019, 33(7):1784-1793
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • ...
  • 生物活性
    Description: Isoacteoside exhibits significant inhibition of advanced glycation end product formation with IC50 values of 4.6-25.7 μM; it has neuroprotective, antioxidant, and anti-inflammatory effects. Isoacteoside can stimulate the increase of α7 and α3 proteins in the cultured cells, attenuate the decreased expression of α3 and α7 nAChR subunit proteins and cell viability on SH-SY5Y cells induced by Aβ; it can regulate caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B pathways.
    Targets: IL Receptor | TNF-α | Caspase | p38MAPK | NF-kB | ERK | JNK | Beta Amyloid | AChR
    In vitro:
    Immunopharmacol Immunotoxicol. 2015 May 15:1-7.
    Anti-inflammatory effects of isoacteoside from Abeliophyllum distichum.[Pubmed: 25975581]
    Isoacteoside, a dihydroxypheynylethyl glycoside, is a major bioactive component of Abeliophyllum distichum (White Forsythia) which is a deciduous shrub native to the south and central areas of Korea. The present study is designed to evaluate the anti-inflammatory activities and underlying mechanisms of isoacteoside in human mast cell line, HMC-1 cells.
    METHODS AND RESULTS:
    We isolated isoacteoside from A. distichum. The anti-inflammatory effect of isoacteoside was investigated in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor alpha (TNF-α) secretion and mRNA expression by ELISA and RT-PCR, respectively. In addition, mechanism related to anti-inflammatory was investigated by Western blotting. Isoacteoside significantly suppressed the production and mRNA expression of proinflammatory cytokines including IL-1β, IL-6, IL-8 and TNF-α in PMACI-stimulated HMC-1 cells without cytotoxicity. It was found that anti-inflammatory effects of isoacteoside are mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B pathways.
    CONCLUSIONS:
    Taken together, the present findings provide new insights that isoacteoside may be a promising anti-inflammatory agent for inflammatory disorders.
    Bot Stud. 2013 Dec;54(1):6.
    Inhibitory activities of acteoside, isoacteoside, and its structural constituents against protein glycation in vitro.[Pubmed: 28510849 ]
    Advanced glycation end products (AGE) are substances that can induce insulin resistance in adipocyte, hepatocyte and muscle cells. This resistance correlates highly with cardiovascular disease and diabetic complications. Acteoside (A), a phenylethanoid glycoside, is an active compound in several plants and traditional herbal medicines. Acteoside, its structural isomer, isoacteoside (I), and their constituents, caffeic acid (C) and 3,4-dihydroxyphenylethanol (D), were used in the study to investigate the inhibitory activity against AGE formations in vitro.
    METHODS AND RESULTS:
    AGE formations were detected by anti-(Nϵ-(carboxymethyl)lysine (anti-CML), using bovine serum albumin (BSA)/glucose (glc) and BSA/galactose (gal) as models, or by anti-argpyrimidine (anti-AP), using BSA/methylglyoxal (MGO) as models. It was found that A, I, C, or D, each at 5 mM, could attenuate the CML formations detected by ELISA in the BSA/gal model of a 3-day or 5-day reaction, and showed significant differences (P < 0.01 or P < 0.001) compared to the control. However, these compounds showed a minor effect after a 7-day incubation. It was also found that C or D could lower the CML formations in the BSA/glc model and showed significant differences (P < 0.05 or P < 0.01) compared to the control after a 3-day, 5-day and 7-day reaction. It was found that A, I, C, or D, each at 0.5 mM or 5 mM, could attenuate the AP formations in the BSA/MGO model of a 3-day reaction and showed significant differences (P < 0.001) compared to the control.
    CONCLUSIONS:
    The results suggest the potential anti-glycation activities of A and I in vitro may apply to cell models at higher glucose concentrations or to diabetic animal models, and need further investigation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.601 mL 8.0051 mL 16.0102 mL 32.0205 mL 40.0256 mL
    5 mM 0.3202 mL 1.601 mL 3.202 mL 6.4041 mL 8.0051 mL
    10 mM 0.1601 mL 0.8005 mL 1.601 mL 3.202 mL 4.0026 mL
    50 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
    100 mM 0.016 mL 0.0801 mL 0.1601 mL 0.3202 mL 0.4003 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    贞桐苷A; Clerodenoside A CFN99691 164022-75-7 C35H44O17 = 736.7 5mg QQ客服:1148253675
    鞭打绣球苷A; Hemiphroside A CFN99697 165338-27-2 C31H40O16 = 668.7 5mg QQ客服:1148253675
    鞭打绣球苷B; Hemiphroside B CFN99698 165338-28-3 C31H38O17 = 682.6 5mg QQ客服:2932563308
    鞭打绣球苷B十乙酰酯; Hemiphroside B nonaacetate CFN89035 132302-25-1 C49H56O26 = 1060.98 5mg QQ客服:215959384
    连翘酯苷A; Forsythoside A CFN99705 79916-77-1 C29H36O15 = 624.59 20mg QQ客服:1413575084
    连翘酯苷I; Forsythoside I CFN90988 1177581-50-8 C29H36O15 = 624.59 5mg QQ客服:215959384
    细叶远志苷 A; Tenuifoliside A CFN90770 139726-35-5 C31H38O17 = 682.6 20mg QQ客服:215959384
    3,6-二芥子酰基蔗糖; 3,6'-Disinapoyl sucrose CFN90578 139891-98-8 C34H42O19 = 754.68 20mg QQ客服:1148253675
    3-阿魏酸酯-1-芥子酰基蔗糖; 3-Feruloyl-1-Sinapoyl sucrose CFN93305 98942-06-4 C33H40O18 = 724.66 5mg QQ客服:2159513211
    毛蕊花糖苷; 麦角甾苷; Acteoside CFN97048 61276-17-3 C29H36O15 = 624.6 20mg QQ客服:1148253675

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