| In vitro: |
| Planta Med. 1998 Mar;64(2):120-5. | | Hepatoprotective activity of phenylethanoids from Cistanche deserticola.[Pubmed: 9525102 ] |
METHODS AND RESULTS:
Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D-GalN).
CONCLUSIONS:
Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo. | | Planta Med. 2005 Aug;71(8):778-80. | | In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma.[Pubmed: 16142646 ] |
METHODS AND RESULTS:
Ten phenylethanoid glycosides, forsythoside B, acteoside, 2'-Acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system.
CONCLUSIONS:
These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 microM. |
|
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