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  • 和厚朴酚

    Honokiol

    和厚朴酚
    产品编号 CFN99902
    CAS编号 35354-74-6
    分子式 = 分子量 C18H18O2 = 266.34
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The barks of Magnolia officinalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    和厚朴酚 CFN99902 35354-74-6 10mg QQ客服:3257982914
    和厚朴酚 CFN99902 35354-74-6 20mg QQ客服:3257982914
    和厚朴酚 CFN99902 35354-74-6 50mg QQ客服:3257982914
    和厚朴酚 CFN99902 35354-74-6 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Hamdard University (India)
  • Sapienza University of Rome (Italy)
  • National Cancer Center Research Institute (Japan)
  • CSIRO - Agriculture Flagship (Australia)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Aveiro University (Portugal)
  • Mahatma Gandhi University (India)
  • Ain Shams University (Egypt)
  • Kamphaengphet Rajabhat University (Thailand)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Copenhagen University (Denmark)
  • Kyung Hee University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Korea Society of Pha.2014, 300-314
  • Int J Mol Sci.2015, 16(1):1232-51
  • Molecules.2016, 21(6)
  • Int J Mol Med.2016, 37(2):501-8
  • Biochem Systematics and Ecology2017, 11-18
  • Universidade Estadual Paulista2017, 42785
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Sci Rep. 2018, 1-9
  • Int J Mol Sci.2018, 19(9):E2681
  • Chemistry of Natural Compounds2018, 204–206
  • Molecules.2018, 23(11):E2837
  • Nat Prod Sci.2018, 24(2):109-114
  • Industrial Crops and Products2018, 353-362
  • Biol Pharm Bull.2018, 41(1):65-72
  • Oncology Letters2018, 4690-4696
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Cancer Manag Res.2019, 11:483-500
  • J of Essential Oil Research2019, 1677272
  • J Adv Res.2019, 17:85-94
  • Spectrochim Acta A2019, 210:372-380
  • Molecules.2019, 24(22):E4022
  • Med Sci Monit.2019, 25:9499-9508
  • ...
  • 生物活性
    Description: Honokiol has antibacterial, anti-angiogenesis, antidepressant-like, antioxidant, anti-inflammatory and anti-cancer effects. It inhibited the activation of Akt and enhances the phosphorylation of ERK1/ERK2. It can improve learning, memory impairments and neuroinflammatory processes induced by SCOP in mice, by inhibition of AChE activity.
    Targets: NOS | NO | 5-HT Receptor | cAMP | PGE | COX | ERK | IL Receptor | ROS | TNF-α | Antifection | AChR | Akt
    In vitro:
    J. Biol. Chem., 2003, 278(37):35501-7.
    Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo.[Reference: WebLink]
    Natural products comprise a major source of small molecular weight angiogenesis inhibitors.
    METHODS AND RESULTS:
    We have used the transformed endothelial cell line SVR as an effective screen of natural product extracts to isolate anti-angiogenesis and anti-tumor compounds. Aqueous extracts of Magnolia grandiflora exhibit potent activity in our SVR proliferation assays. We found that the small molecular weight compound Honokiol is the active principle of magnolia extract. Honokiol exhibited potent anti-proliferative activity against SVR cells in vitro. In addition, Honokiol demonstrated preferential inhibition of primary human endothelial cells compared with fibroblasts and this inhibition was antagonized by antibodies against TNFα-related apoptosis-inducing ligand. In vivo, Honokiol was highly effective against angiosarcoma in nude mice.
    CONCLUSIONS:
    Our preclinical data suggests that Honokiol is a systemically available and non-toxic inhibitor of angiogenesis and should be further evaluated as a potential chemotherapeutic agent.
    Eur J Pharmacol. 2004 Aug 2;496(1-3):189-95.
    In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp.[Pubmed: 15288590 ]
    Honokiol and magnolol, two major phenolic constituents of Magnolia sp., have been known to exhibit antibacterial activities. However, until now, their antibacterial activity against Propionibacterium sp. has not been reported.
    METHODS AND RESULTS:
    To this end, the antibacterial activities of Honokiol and magnolol were detected using the disk diffusion method and a two-fold serial dilution assay. Honokiol and magnolol showed strong antibacterial activities against both Propionibacterium acnes and Propionibacterium granulosum, which are acne-causing bacteria. The minimum inhibitory concentrations (MIC) of Honokiol and magnolol was 3-4 microg/ml (11.3-15 microM) and 9 microg/ml (33.8 microM), respectively. In addition, the killing curve analysis showed that magnolol and Honokiol killed P. acnes rapidly, with 10(5) organisms/ml eliminated within 10 min of treatment with either 45 microg (169.2 microM) of magnolol or 20 microg (75.2 microM) of Honokiol per ml. The cytotoxic effect of Honokiol and magnolol was determined by a colorimetric (3-(4,5-dimetyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) (MTT) assay using two animal cell lines, human normal fibroblasts and HaCaT. In this experiment, magnolol exhibited lower cytotoxic effects than Honokiol at the same concentration, but they showed similar cytotoxicity when triclosan was employed as an acne-mitigating agent. In addition, they reduced secretion of interleukin-8 and tumor necrosis factor alpha (TNF-alpha) induced by P. acnes in THP-1 cells indicating the anti-inflammatory effects of them. When applied topically, neither phenolic compound induced any adverse reactions in a human skin primary irritation test.
    CONCLUSIONS:
    Therefore, based on these results, we suggest the possibility that magnolol and Honokiol may be considered as attractive acne-mitigating candidates for topical application.
    In vivo:
    Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):715-25.
    Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents.[Pubmed: 18093712 ]
    Honokiol and magnolol are the main constituents simultaneously identified in the barks of Magnolia officinalis, which have been used in traditional Chinese medicine to treat a variety of mental disorders including depression.
    METHODS AND RESULTS:
    The mixture of Honokiol and magnolol at 20 and 40 mg/kg significantly attenuated CMS-induced decreases of 5-HT levels in frontal cortex, hippocampus, striatum, hypothalamus and nucleus accumbens. And it markedly increased 5-HIAA levels in frontal cortex, striatum and nucleus accumbens at 40 mg/kg and in frontal cortex at 20 mg/kg in the CMS rats. A subsequent reduction in 5-HIAA/5-HT ratio was found in hippocampus and nucleus accumbens in the CMS rats receiving this mixture. Furthermore, the mixture of Honokiol and magnolol reduced elevated corticosterone concentrations in serum to normalize the hypothalamic-pituitary-adrenal (HPA) hyperactivity in the CMS rats. It also reversed CMS-induced reduction in platelet AC activity, via upregulating the cyclic adenosine monophosphate (cAMP) pathway. These results suggested that the mixture of Honokiol and magnolol possessed potent antidepressant-like properties in behaviors involved in normalization of biochemical abnormalities in brain 5-HT and 5-HIAA, serum corticosterone levels and platelet AC activity in the CMS rats.
    CONCLUSIONS:
    Our findings could provide a basis for examining directly the interaction of the serotonergic system, the HPA axis and AC-cAMP pathway underlying the link between depression and treatment with the mixture of Honokiol and magnolol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7546 mL 18.773 mL 37.546 mL 75.092 mL 93.865 mL
    5 mM 0.7509 mL 3.7546 mL 7.5092 mL 15.0184 mL 18.773 mL
    10 mM 0.3755 mL 1.8773 mL 3.7546 mL 7.5092 mL 9.3865 mL
    50 mM 0.0751 mL 0.3755 mL 0.7509 mL 1.5018 mL 1.8773 mL
    100 mM 0.0375 mL 0.1877 mL 0.3755 mL 0.7509 mL 0.9386 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    四氢厚朴酚; Tetrahydromagnolol CFN91033 20601-85-8 C18H22O2 = 270.4 20mg QQ客服:215959384
    厚朴酚; Magnolol CFN98872 528-43-8 C18H18O2 = 266.3 20mg QQ客服:1148253675
    和厚朴酚; Honokiol CFN99902 35354-74-6 C18H18O2 = 266.34 20mg QQ客服:3257982914
    异红花八角醇; Isodunnianol CFN99449 139726-30-0 C27H26O3 = 398.5 5mg QQ客服:215959384
    红花八角醇; Dunnianol CFN99448 139726-29-7 C27H26O3 = 398.5 5mg QQ客服:215959384
    Simonsinol; Simonsinol CFN99661 155709-40-3 C27H26O3 = 398.5 5mg QQ客服:215959384
    木兰素; Magnolianin CFN96079 147663-91-0 C54H50O8 = 827.0 5mg QQ客服:3257982914
    厚朴木酚素A; Magnolignan A CFN96188 93673-81-5 C18H20O4 = 300.4 5mg QQ客服:1148253675
    厚朴木酚素C; Magnolignan C CFN96189 93697-42-8 C18H20O4 = 300.4 5mg QQ客服:2932563308
    (1S,2S)-threo-Honokitriol; (1S,2S)-threo-Honokitriol CFN95076 1099687-80-5 C18H20O5 = 316.4 5mg QQ客服:3257982914

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