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  • 异红花八角醇

    Isodunnianol

    异红花八角醇
    产品编号 CFN99449
    CAS编号 139726-30-0
    分子式 = 分子量 C27H26O3 = 398.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Illicium fargesii
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异红花八角醇 CFN99449 139726-30-0 1mg QQ客服:3257982914
    异红花八角醇 CFN99449 139726-30-0 5mg QQ客服:3257982914
    异红花八角醇 CFN99449 139726-30-0 10mg QQ客服:3257982914
    异红花八角醇 CFN99449 139726-30-0 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Calcutta University (India)
  • Seoul National University of Science and Technology (Korea)
  • Universidade de Franca (Brazil)
  • University of Padjajaran (Indonesia)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Sri Ramachandra University (India)
  • Aarhus University (Denmark)
  • University of British Columbia (Canada)
  • Celltrion Chemical Research Institute (Korea)
  • Lund University (Sweden)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Charles Sturt University (Denmark)
  • Medical University of South Carolina (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antiviral Res.2013, 98(3):386-93
  • Int J Mol Med.2015, 35(5):1237-45
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Pharm Biol.2016, 54(7):1255-62
  • Acta horticulturae2017, 1158:257-268
  • Research on Crops.2017, 18(3):569
  • Int J Mol Sci.2017, 19(1)
  • Int J Anal Chem.2017, 2017:1254721
  • Universite de Bordeaux2017, 2017BORD0867
  • J Biochem Mol Toxicol.2017, 31(9)
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Mol Pharm.2018, 15(8):3285-3296
  • Life Sci.2018, 209:498-506
  • Food Res Int.2019, 123:125-134
  • J Pharm Biomed Anal.2019, 172:268-277
  • BMC Complement Altern Med.2019, 19(1):11
  • Molecules.2019, 24(21):E3834
  • Cell Chem Biol.2019, 26(1):27-34
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Kor. J. Herbol.2019, 34(2):59-66
  • Phytomedicine.2019, 56:48-56
  • Phytomedicine.2019, 58:152893
  • ...
  • 生物活性
    Description: Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the primary cultured rat cortical neurons. Isodunnianol, dunnianol, and Macranthol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5 -3.0 fold and decrease cellular oxidative stress by 40-65%, they show substantial activity against iNOS.
    Targets: NF-kB | NOS | ROS | AChR
    In vitro:
    Tetrahedron, 2007,63(20): 4243–4249.
    Structure and neurotrophic activity of novel sesqui-neolignans from the pericarps of Illicium fargesii[Reference: WebLink]

    METHODS AND RESULTS:
    The structures of three new sesqui-neolignans, fargenin (1) and fargenones A and B (2 and 3), together with two previously known sesqui-neolignans, macranthol (4) and isodunnianol (5), isolated from the methanol extract of the pericarps of Illicium fargesii were elucidated on the basis of spectroscopic data. Compounds 1–3 are the second three examples of the sesqui-neolignans that contain a variety of non-aromatic rings, and their plausible biosynthetic routes from chavicol are proposed.
    CONCLUSIONS:
    Among the isolated sesqui-neolignans, isodunnianol has been found to exhibit neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 μM in the primary cultured rat cortical neurons.
    Planta Med.,2014, 80(10):807-807.
    Compounds from the bark of Illicium tsaii and their anti-inflammatory activity[Reference: WebLink]
    Illicium tsaii is a Chinese native species growing in northwest China. The bark of I. tsaii, has been applied for the treatment of rheumatoid arthritis. Phytochemical investigation on this species resulted in the isolation and characterization of 28 compounds from the stem bark of I. tsaii.
    METHODS AND RESULTS:
    Structure determination was accomplished by means of spectroscopic data interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation such as NAG-1, NF-κB, iNOS and ROS. Sesquilignans showed significant activity, among which dunnianol, macranthol and Isodunnianol increased NAG-1 activity 1.5 – 3.0 fold and decreased cellular oxidative stress by 40 – 65%.
    CONCLUSIONS:
    These three compounds showed substantial activity against iNOS, while only macranthol showed activity against NF-κB. This is the first study on the constituents of I. tsaii and evaluation of their biological activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5094 mL 12.5471 mL 25.0941 mL 50.1882 mL 62.7353 mL
    5 mM 0.5019 mL 2.5094 mL 5.0188 mL 10.0376 mL 12.5471 mL
    10 mM 0.2509 mL 1.2547 mL 2.5094 mL 5.0188 mL 6.2735 mL
    50 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.0038 mL 1.2547 mL
    100 mM 0.0251 mL 0.1255 mL 0.2509 mL 0.5019 mL 0.6274 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    厚朴醛D; Magnaldehyde D CFN96172 93753-33-4 C16H14O3 = 254.3 5mg QQ客服:2932563308
    四氢厚朴酚; Tetrahydromagnolol CFN91033 20601-85-8 C18H22O2 = 270.4 20mg QQ客服:2932563308
    厚朴酚; Magnolol CFN98872 528-43-8 C18H18O2 = 266.3 20mg QQ客服:2159513211
    和厚朴酚; Honokiol CFN99902 35354-74-6 C18H18O2 = 266.34 20mg QQ客服:2932563308
    异红花八角醇; Isodunnianol CFN99449 139726-30-0 C27H26O3 = 398.5 5mg QQ客服:2932563308
    红花八角醇; Dunnianol CFN99448 139726-29-7 C27H26O3 = 398.5 5mg QQ客服:1148253675
    Simonsinol; Simonsinol CFN99661 155709-40-3 C27H26O3 = 398.5 5mg QQ客服:3257982914
    木兰素; Magnolianin CFN96079 147663-91-0 C54H50O8 = 827.0 5mg QQ客服:215959384
    厚朴木酚素A; Magnolignan A CFN96188 93673-81-5 C18H20O4 = 300.4 5mg QQ客服:1413575084
    厚朴木酚素C; Magnolignan C CFN96189 93697-42-8 C18H20O4 = 300.4 5mg QQ客服:2932563308

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