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  • 哈巴苷


    产品编号 CFN98148
    CAS编号 6926-08-5
    分子式 = 分子量 C15H24O10 = 364.35
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Iridoids
    植物来源 The roots of Scrophularia ningpoensis Hemsl.
    产品名称 产品编号 CAS编号 包装 QQ客服
    哈巴苷 CFN98148 6926-08-5 10mg QQ客服:215959384
    哈巴苷 CFN98148 6926-08-5 20mg QQ客服:215959384
    哈巴苷 CFN98148 6926-08-5 50mg QQ客服:215959384
    哈巴苷 CFN98148 6926-08-5 100mg QQ客服:215959384
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • University of Oslo (Norway)
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  • Universite Libre de Bruxelles (Belgium)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • Food Chem.2016, 191:81-90
  • Eur J Pharm Sci.2016, 94:33-45
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  • Biomol Ther (Seoul).2019, 10.4062
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  • ...
  • 生物活性
    Description: Harpagide has neuroprotective effect, it can obviously protect acute cerebral ischemia in mice,its therapeutical effects are approached to protecting the activity of brain mitochondria and decreasing protein expression level of caspase-3; harpagide also has a potential for prevention of bone loss in ovariectomized (OVX) mice by regulating the stimulation of osteoblast differentiation and the suppression of osteoclast formation. Harpagide may have anti-inflammatory efficacy.
    Targets: TNF-α | NO | COX | Caspase | Calcium Channel | ATPase
    In vitro:
    Bioorg Med Chem. 2011 Aug 15;19(16):4882-6.
    Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro.[Pubmed: 21775152 ]
    Harpagide (1) and harpagoside (2) are two iridoid glycosides existing in many medicinal plants. Although they are believed to be the main bioactive compounds related to the anti-inflammatory efficacy of these plants, the mechanisms of their anti-inflammatory activities remain unclear.
    The results of our present study showed that 1 and 2 had no effects on inhibitions of cyclooxygenase (COX)-1/2 enzyme activity, tumor necrosis factor-α (TNF-α) release, and nitric oxide (NO) production in vitro. However, the hydrolyzed products of 1 and 2 with β-glucosidase treatment showed a significant inhibitory effect on COX-2 activity at 2.5-100 μM in a concentration-dependent manner. Our further study revealed that the hydrolyzed 2 product was structurally the same as the hydrolyzed 1 product (H-harpagide (3)). The structure of 3 was 2-(formylmethyl)-2,3,5-trihydroxy-5-methylcyclopentane carbaldehyde, with a backbone similar to prostaglandins and COX-2 inhibitors such as celecoxib. All of them have a pentatomic ring with two adjacent side chains.
    The result of molecular modeling and docking study showed that 3 could bind to the COX-2 active domain well through hydrophobic and hydrogen-bonding interactions, whereas 1 and 2 could not, implying that the hydrolysis of the glycosidic bond of 1 and 2 is a pre-requisite step for their COX-2 inhibitory activity.
    In vivo:
    Journal of Chinese Pharmaceutical Sciences, 2015, 50(12):1026-31.
    Neuro-protective effect of harpagide on acute cerebral ischemic injury in mice and its mechanism involving mitochondria.[Reference: WebLink]
    To observe the neuro-protective effects of harpagide on acute cerebral ischemic injury in mice and its mechanism involving mitochondria.
    Acute cerebral ischemia were achieved by operation of MCAO in the left brain, random allocation was taken to divide ICR mice into sham group, model group, nimodipine group and harpagide (5,10,15 mg·kg-1) groups. Mice were intraperitoneal injected harpagide immediately after surgeiy. Nerve function score, content of brain water, brain index and the common changes of brain pathological structure in HE staining were measured: Ability of mitochondria Ca2+-Mg2+-AT-Pase and protein expression level of caspase-3 in the MCAO mice' brains was determined: Ultrastructure change of mitochondria under the TEM was observed. Compared with model group, the harpagide groups could decreased the nerve function score, the content of brain water, brain index and the volume of ischemia in mice with different degrees in MCAO mice (P<0.05, P<0.01). 10 mg·kg-1 of harpagide could increased the activity of Ca2+-Mg2+-ATPase obviously (P<0.01): And significantly decreased the protein expression level of caspase-3 (P<0.01): harpagide groups could protect the pathogeny structure and the ultrastructure of mitochondria with different degrees in MCAO mice, decrease edema of mitochondria obviously.
    Harpagide could obviously protect acute cerebral ischemia in mice, its therapeutical effects are approached to protecting the activity of brain mitochondria and decreasing protein expression level of caspase-3.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7446 mL 13.7231 mL 27.4461 mL 54.8923 mL 68.6153 mL
    5 mM 0.5489 mL 2.7446 mL 5.4892 mL 10.9785 mL 13.7231 mL
    10 mM 0.2745 mL 1.3723 mL 2.7446 mL 5.4892 mL 6.8615 mL
    50 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.0978 mL 1.3723 mL
    100 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.5489 mL 0.6862 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-O-肉桂酰哈巴苷; 8-p-Coumaroylharpagide CFN70464 87686-74-6 C24H30O12 = 510.5 5mg QQ客服:1413575084
    益母草苷; Ajugol CFN90759 52949-83-4 C15H24O9 = 348.4 20mg QQ客服:215959384
    地黄苷C; Rehmannioside C CFN80135 81720-07-2 C21H34O14 = 510.49 5mg QQ客服:3257982914
    6-O-香草酰基筋骨草醇; 6-O-Vanilloylajugol CFN99354 124168-04-3 C23H30O12 = 498.5 5mg QQ客服:1413575084
    6-O-丁香酰筋骨草醇; 6-O-Syringoylajugol CFN99483 144049-72-9 C24H32O13 = 528.5 5mg QQ客服:215959384
    6-表-8-O-乙酰基哈帕甙; 6-Epi-8-O-acetylharpagide CFN97590 97169-44-3 C17H26O11 = 406.39 5mg QQ客服:215959384
    6-表哈巴俄苷; 6-Epiharpagoside CFN96074 1151862-67-7 C24H30O11 = 494.5 5mg QQ客服:1413575084
    哈巴苷; Harpagide CFN98148 6926-08-5 C15H24O10 = 364.35 20mg QQ客服:2932563308
    8-O-乙酰哈巴苷; 8-O-Acetylharpagide CFN97181 6926-14-3 C17H26O11 = 406.4 20mg QQ客服:1148253675
    8-O-苯甲酰哈巴苷; Caprarioside CFN96976 1151862-69-9 C22H28O11 = 342.29 5mg QQ客服:1413575084





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