• 中药标准品生产商,产品定制服务
  • 哈巴苷

    Harpagide

    哈巴苷
    产品编号 CFN98148
    CAS编号 6926-08-5
    分子式 = 分子量 C15H24O10 = 364.35
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Iridoids
    植物来源 The roots of Scrophularia ningpoensis Hemsl.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    哈巴苷 CFN98148 6926-08-5 10mg QQ客服:215959384
    哈巴苷 CFN98148 6926-08-5 20mg QQ客服:215959384
    哈巴苷 CFN98148 6926-08-5 50mg QQ客服:215959384
    哈巴苷 CFN98148 6926-08-5 100mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Oslo (Norway)
  • Srinakharinwirot University (Thailand)
  • Ateneo de Manila University (Philippines)
  • National Cancer Center Research Institute (Japan)
  • Universite Libre de Bruxelles (Belgium)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • University of Zurich (Switzerland)
  • Charles Sturt University (Denmark)
  • Monash University (Australia)
  • Universidade Federal de Santa Catarina (Brazil)
  • Cornell University (USA)
  • Kitasato University (Japan)
  • Lund University (Sweden)
  • Washington State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Auburn University2015, 1-58
  • Phytochemistry Letters2015, 243-247
  • Inflammation2015, 38(1):445-55
  • University of Limpopo2016, 1-237
  • Food Chem.2016, 191:81-90
  • Eur J Pharm Sci.2016, 94:33-45
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Nat Prod Commun.2017, 12(5):771-778
  • Mol Pharm.2017, 14(9):3164-3177
  • J Biochem Mol Toxicol.2017, 31(9)
  • Industrial Crops and Products2017, 95:286-295
  • Oncology Letters2018, 4690-4696
  • Biomol Ther (Seoul).2019, 10.4062
  • Front Pharmacol.2019, 10:1025
  • APMIS.2019, 127(10):688-695
  • Int J Mol Sci.2019, 20(9):E2244
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Phytomedicine.2019, 58:152893
  • Phytomedicine.2019, 67:153159
  • Planta Med.2019, 85(3):217-224
  • Oxid Med Cell Longev2019, 9056845:13
  • Drug Des Devel Ther.2020, 14:61-71
  • ...
  • 生物活性
    Description: Harpagide has neuroprotective effect, it can obviously protect acute cerebral ischemia in mice,its therapeutical effects are approached to protecting the activity of brain mitochondria and decreasing protein expression level of caspase-3; harpagide also has a potential for prevention of bone loss in ovariectomized (OVX) mice by regulating the stimulation of osteoblast differentiation and the suppression of osteoclast formation. Harpagide may have anti-inflammatory efficacy.
    Targets: TNF-α | NO | COX | Caspase | Calcium Channel | ATPase
    In vitro:
    Bioorg Med Chem. 2011 Aug 15;19(16):4882-6.
    Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro.[Pubmed: 21775152 ]
    Harpagide (1) and harpagoside (2) are two iridoid glycosides existing in many medicinal plants. Although they are believed to be the main bioactive compounds related to the anti-inflammatory efficacy of these plants, the mechanisms of their anti-inflammatory activities remain unclear.
    METHODS AND RESULTS:
    The results of our present study showed that 1 and 2 had no effects on inhibitions of cyclooxygenase (COX)-1/2 enzyme activity, tumor necrosis factor-α (TNF-α) release, and nitric oxide (NO) production in vitro. However, the hydrolyzed products of 1 and 2 with β-glucosidase treatment showed a significant inhibitory effect on COX-2 activity at 2.5-100 μM in a concentration-dependent manner. Our further study revealed that the hydrolyzed 2 product was structurally the same as the hydrolyzed 1 product (H-harpagide (3)). The structure of 3 was 2-(formylmethyl)-2,3,5-trihydroxy-5-methylcyclopentane carbaldehyde, with a backbone similar to prostaglandins and COX-2 inhibitors such as celecoxib. All of them have a pentatomic ring with two adjacent side chains.
    CONCLUSIONS:
    The result of molecular modeling and docking study showed that 3 could bind to the COX-2 active domain well through hydrophobic and hydrogen-bonding interactions, whereas 1 and 2 could not, implying that the hydrolysis of the glycosidic bond of 1 and 2 is a pre-requisite step for their COX-2 inhibitory activity.
    In vivo:
    Journal of Chinese Pharmaceutical Sciences, 2015, 50(12):1026-31.
    Neuro-protective effect of harpagide on acute cerebral ischemic injury in mice and its mechanism involving mitochondria.[Reference: WebLink]
    To observe the neuro-protective effects of harpagide on acute cerebral ischemic injury in mice and its mechanism involving mitochondria.
    METHODS AND RESULTS:
    Acute cerebral ischemia were achieved by operation of MCAO in the left brain, random allocation was taken to divide ICR mice into sham group, model group, nimodipine group and harpagide (5,10,15 mg·kg-1) groups. Mice were intraperitoneal injected harpagide immediately after surgeiy. Nerve function score, content of brain water, brain index and the common changes of brain pathological structure in HE staining were measured: Ability of mitochondria Ca2+-Mg2+-AT-Pase and protein expression level of caspase-3 in the MCAO mice' brains was determined: Ultrastructure change of mitochondria under the TEM was observed. Compared with model group, the harpagide groups could decreased the nerve function score, the content of brain water, brain index and the volume of ischemia in mice with different degrees in MCAO mice (P<0.05, P<0.01). 10 mg·kg-1 of harpagide could increased the activity of Ca2+-Mg2+-ATPase obviously (P<0.01): And significantly decreased the protein expression level of caspase-3 (P<0.01): harpagide groups could protect the pathogeny structure and the ultrastructure of mitochondria with different degrees in MCAO mice, decrease edema of mitochondria obviously.
    CONCLUSIONS:
    Harpagide could obviously protect acute cerebral ischemia in mice, its therapeutical effects are approached to protecting the activity of brain mitochondria and decreasing protein expression level of caspase-3.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7446 mL 13.7231 mL 27.4461 mL 54.8923 mL 68.6153 mL
    5 mM 0.5489 mL 2.7446 mL 5.4892 mL 10.9785 mL 13.7231 mL
    10 mM 0.2745 mL 1.3723 mL 2.7446 mL 5.4892 mL 6.8615 mL
    50 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.0978 mL 1.3723 mL
    100 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.5489 mL 0.6862 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-O-肉桂酰哈巴苷; 8-p-Coumaroylharpagide CFN70464 87686-74-6 C24H30O12 = 510.5 5mg QQ客服:1413575084
    益母草苷; Ajugol CFN90759 52949-83-4 C15H24O9 = 348.4 20mg QQ客服:215959384
    地黄苷C; Rehmannioside C CFN80135 81720-07-2 C21H34O14 = 510.49 5mg QQ客服:3257982914
    6-O-香草酰基筋骨草醇; 6-O-Vanilloylajugol CFN99354 124168-04-3 C23H30O12 = 498.5 5mg QQ客服:1413575084
    6-O-丁香酰筋骨草醇; 6-O-Syringoylajugol CFN99483 144049-72-9 C24H32O13 = 528.5 5mg QQ客服:215959384
    6-表-8-O-乙酰基哈帕甙; 6-Epi-8-O-acetylharpagide CFN97590 97169-44-3 C17H26O11 = 406.39 5mg QQ客服:215959384
    6-表哈巴俄苷; 6-Epiharpagoside CFN96074 1151862-67-7 C24H30O11 = 494.5 5mg QQ客服:1413575084
    哈巴苷; Harpagide CFN98148 6926-08-5 C15H24O10 = 364.35 20mg QQ客服:2932563308
    8-O-乙酰哈巴苷; 8-O-Acetylharpagide CFN97181 6926-14-3 C17H26O11 = 406.4 20mg QQ客服:1148253675
    8-O-苯甲酰哈巴苷; Caprarioside CFN96976 1151862-69-9 C22H28O11 = 342.29 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产