• 中药标准品生产商,产品定制服务
  • 8-O-乙酰哈巴苷

    8-O-Acetylharpagide

    8-O-乙酰哈巴苷
    产品编号 CFN97181
    CAS编号 6926-14-3
    分子式 = 分子量 C17H26O11 = 406.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The roots of Scrophularia ningpoensis Hemsl.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    8-O-乙酰哈巴苷 CFN97181 6926-14-3 10mg QQ客服:1148253675
    8-O-乙酰哈巴苷 CFN97181 6926-14-3 20mg QQ客服:1148253675
    8-O-乙酰哈巴苷 CFN97181 6926-14-3 50mg QQ客服:1148253675
    8-O-乙酰哈巴苷 CFN97181 6926-14-3 100mg QQ客服:1148253675
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of the Basque Country (Spain)
  • University Medical Center Mainz (Germany)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Tohoku University (Japan)
  • Universidad Industrial de Santander (Colombia)
  • Wageningen University (Netherlands)
  • Seoul National University (Korea)
  • University of Eastern Finland (Finland)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • University of Leipzig (Germany)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Ain Shams University (Egypt)
  • University of Cincinnati (USA)
  • Nanjing University of Chinese Medicine (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. of Med. Plant Research.2013, 90-151
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Molecules.2015, 20(11):20014-30
  • Acta Physiologiae Plantarum2015, 37:1736
  • Inflammation2015, 38(1):445-55
  • Inflammation.2015, 38(4):1502-16
  • Acta horticulturae2017, 1158:257-268
  • J. of The Korean Society of Food Culture2017, 144-149
  • Universidade Estadual Paulista2017, 42785
  • J Nat Med.2017, 71(2):457-462
  • Journal of Analytical Chemistry2017, 854-861
  • J Hematol Oncol.2018, 11(1):112
  • Phytomedicine.2018, 47:48-57
  • Arch Biochem Biophys.2018, 644:93-99
  • Front Immunol.2018, 9:2091
  • Front Aging Neurosci.2019, 11:230
  • Int J Mol Sci.2019, 20(23):E6071
  • Molecules.2019, 24(7):E1290
  • Oncol Rep.2019, 41(4):2453-2463
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • J Clin Med.2019, 8(10):E1664
  • Sci Rep.2019, 9(1):4342
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • ...
  • 生物活性
    Description: 8-O-Acetylharpagide has anti-inflammatory, vasoconstrictor, antibacteria and antiviral activities, it also has a biological activity on isolated smooth muscle preparations from guinea pig. 8-O-Acetylharpagide presents the obvious inhibition on Epstein-Barr virus(EBV) infection, it not only apparently inhibits EBV-VCA,but also alleviates the hyperfunction and effusion of capillary permeability at the early inflammation.
    Targets: Antifection
    In vitro:
    J Nat Prod. 1992 Aug;55(8):1145-8.
    Vasoconstrictor activity of 8-O-acetylharpagide from Ajuga reptans.[Pubmed: 1431938]
    The traditional therapeutic indications for the use of Ajuga reptans (Labiatae) have been investigated. The H2O-soluble part of a crude and partially purified MeOH extract and two isolated iridoids (8-O-acetylharpagide and harpagide), were tested for a biological activity on isolated smooth muscle preparations from guinea pig.
    Insect Biochem Mol Biol. 2001 Oct;31(11):1077-82.
    8-O-acetylharpagide is not an ecdysteroid agonist.[Pubmed: 11520686]

    METHODS AND RESULTS:
    We have reinvestigated the activity of 8-O-acetylharpagide, an iridoid glucoside, as an ecdysteroid agonist. Elbrecht et al. (Insect Biochem. Mol. Biol. 26 (1996) 519) isolated a preparation of this compound from Ajuga reptans L. and ascribed ecdysteroid agonist activity on the basis of the induction of an ecdysteroid-like response in Drosophila melanogaster KcO cells, the displacement of [3H]ponasterone A from the Drosophila receptor and the activation of an ecdysteroid-regulated gene in a transactivation assay. We provide evidence that the agonist activity derives from contaminating ecdysteroids; A. reptans is a species rich in ecdysteroids.
    CONCLUSIONS:
    Purified 8-O-acetylharpagide is not active in the D. melanogaster B(II) cell bioassay, neither as an agonist nor as an antagonist, nor does it displace [3H]ponasterone A from dipteran or lepidopteran ecdysteroid receptor complexes.
    In vivo:
    Zhongguo Zhong Yao Za Zhi. 2013 Jun;38(12):2015-8.
    Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens extract in beagle dog.[Pubmed: 24066603]
    8-O-Acetylharpagide and harpagide are two kinds of effective component of Ajuga decumbens extract. A sensitive LC-MS/MS method has been established for pharmacokinetics of 8-O-Acetylharpagide and harpagide in beagle dog after oral administration of from A. decumbens extract.
    METHODS AND RESULTS:
    Female beagle dogs received orally 12.9, 25.7 mg x kg(-1) p. o. Concentrations of 8-O-Acetylharpagide and harpagide in plasma were determined by LC-MS/MS method at different time points and all pharmacokinetic parameters were estimated by non-compartment analysis. The mobile phase consisted of 0.1% formic acid in water (A) and acetonitrile (B), which was run at a flow rate of 0.3 mL x min(-1). Chromatographic separation was achieved on an Agilent ZORBAX XDB-C18 column (2.1 mm x 50 mm, 3.5 microm) using a gradient elution of 5% B at 0-2 min, 95% B at 2. 1-5 min and 5% B at 5. 1-10 min. All analytes, including the IS, were monitored under positive ionization conditions and quantified in MRM mode with transitions of m/z 429.2-369.2 for 8-O-Acetylharpagide, m/z 387.2-207.2 for harpagide, and m/z 149.2-103.1 for IS. High purity nitrogen was employed as both the nebulizing and drying gas. Other parameters of the mass spectrometer were optimized as follows: drying gas flow 10.0 L x min(-1); drying gas temperature 300 degrees C; capillary voltage 4 000 V. Results showed that 8-O-Acetylharpagide and harpagide showed a dose-dependence profile. T(max) of 8-O-Acetylharpagide is 1.7 h, and T(max) of harpagide is 1.57 h, which was higher than T(max) of 8-O-Acetylharpagide and harpagide after oral administration of from A. decumbens extract in rats.
    CONCLUSIONS:
    The different pharmacokinetic parameters may be due to the species differences of rat and beagle dog.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4606 mL 12.3031 mL 24.6063 mL 49.2126 mL 61.5157 mL
    5 mM 0.4921 mL 2.4606 mL 4.9213 mL 9.8425 mL 12.3031 mL
    10 mM 0.2461 mL 1.2303 mL 2.4606 mL 4.9213 mL 6.1516 mL
    50 mM 0.0492 mL 0.2461 mL 0.4921 mL 0.9843 mL 1.2303 mL
    100 mM 0.0246 mL 0.123 mL 0.2461 mL 0.4921 mL 0.6152 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-O-香草酰基筋骨草醇; 6-O-Vanilloylajugol CFN99354 124168-04-3 C23H30O12 = 498.5 5mg QQ客服:1148253675
    6-O-丁香酰筋骨草醇; 6-O-Syringoylajugol CFN99483 144049-72-9 C24H32O13 = 528.5 5mg QQ客服:215959384
    6-表-8-O-乙酰基哈帕甙; 6-Epi-8-O-acetylharpagide CFN97590 97169-44-3 C17H26O11 = 406.39 5mg QQ客服:1148253675
    6-表哈巴俄苷; 6-Epiharpagoside CFN96074 1151862-67-7 C24H30O11 = 494.5 5mg QQ客服:3257982914
    哈巴苷; Harpagide CFN98148 6926-08-5 C15H24O10 = 364.35 20mg QQ客服:1148253675
    8-O-乙酰哈巴苷; 8-O-Acetylharpagide CFN97181 6926-14-3 C17H26O11 = 406.4 20mg QQ客服:215959384
    8-O-苯甲酰哈巴苷; Caprarioside CFN96976 1151862-69-9 C22H28O11 = 342.29 5mg QQ客服:2159513211
    哈巴俄苷; Harpagoside CFN98147 19210-12-9 C24H30O11 = 494.49 20mg QQ客服:215959384
    8-O-肉桂酰哈巴苷; 8-p-Coumaroylharpagide CFN70464 87686-74-6 C24H30O12 = 510.5 5mg QQ客服:2932563308
    益母草苷; Ajugol CFN90759 52949-83-4 C15H24O9 = 348.4 20mg QQ客服:1148253675

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产