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  • 京尼平

    Genipin

    京尼平
    产品编号 CFN99142
    CAS编号 6902-77-8
    分子式 = 分子量 C11H14O5 = 226.23
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Iridoids
    植物来源 The fruits of Gardenia jasminoides Ellis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    京尼平 CFN99142 6902-77-8 10mg QQ客服:2159513211
    京尼平 CFN99142 6902-77-8 20mg QQ客服:2159513211
    京尼平 CFN99142 6902-77-8 50mg QQ客服:2159513211
    京尼平 CFN99142 6902-77-8 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de La Salle (Mexico)
  • Texas A&M University (USA)
  • Univerzita Karlova v Praze (Czech Republic)
  • Seoul National University of Science and Technology (Korea)
  • University of Wisconsin-Madison (USA)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • The Ohio State University (USA)
  • Worcester Polytechnic Institute (USA)
  • University of Toronto (Canada)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Monash University Sunway Campus (Malaysia)
  • Harvard University (USA)
  • Universite de Lille1 (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. of Med. Plant Research.2013, 90-151
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • FEMS Microbiol Lett.2017, 364(11)
  • Journal of Analytical Chemistry2017, 854-861
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Chem Biol Interact.2018, 283:59-74
  • Front Cell Infect Microbiol.2018, 8:292
  • Analytical methods2019, 11(6)
  • Exp Ther Med.2019, 18(6):4388-4396
  • Int J Mol Sci.2019, 20(14):E3538
  • Int J Mol Sci.2019, 20(16):E4015
  • Molecules.2019, 24(4):E744
  • Molecules.2019, 24(6):E1177
  • Cell Chem Biol.2019, 26(1):27-34
  • Anal Sci.2019, 35(12):1317-1325
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Sci Rep.2019, 9(1):4342
  • Biomolecules.2019, 9(11):E696
  • Psychopharmacology (Berl).2020, 10.1007
  • Plant Growth Regulation2020, 90(2):383-392
  • Cell Metab.2020, S1550-4131(20)30002-4
  • ...
  • 生物活性
    Description: Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking, can be used as a regulating agent for drug delivery, as the raw material for gardenia blue pigment preparation. It is a novel chemical activator of EBV lytic cycle and a cell permeable inhibitor of uncoupling protein 2 (UCP2). Genipin has antimicrobial,antiviral, antitumor, and anti-inflammatory effects, it is used for choleretic action for liver diseases control and could be used for the treatment of periodontal disease to prevent MMPs expression in periodontal lesion. It shows an antithrombotic effect in vivo due to the suppression of platelet aggregation.
    Targets: ERK | TNF-α | MMP(e.g.TIMP) | JNK | AMPK | VEGFR | Phospholipase (e.g. PLA) | COX | NF-kB | PI3K | Akt | ROS | MAPK | AP-1
    In vitro:
    J Microbiol. 2015 Feb;53(2):155-65.
    Genipin as a novel chemical activator of EBV lytic cycle.[Pubmed: 25626372]
    Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that causes acute infection and establishes life-long latency. EBV causes several human cancers, including Burkitt's lymphoma, nasopharyngeal and gastric carcinoma. Antiviral agents can be categorized as virucides, antiviral chemotherapeutic agents, and immunomodulators. Most antiviral agents affect actively replicating viruses, but not their latent forms. Novel antiviral agents must be active on both the replicating and the latent forms of the virus. Gardenia jasminoides is an evergreen flowering plant belonging to the Rubiaceae family and is most commonly found growing wild in Vietnam, Southern China, Taiwan, Japan, Myanmar, and India. Genipin is an aglycone derived from an iridoid glycoside called geniposide, which is present in large quantities in the fruit of G. jasminoides.
    METHODS AND RESULTS:
    In this study, genipin was evaluated for its role as an antitumor and antiviral agent that produces inhibitory effects against EBV and EBV associated gastric carcinoma (EBVaGC). In SNU719 cells, one of EBVaGCs, genipin caused significant cytotoxicity (70 μM), induced methylation on EBV C promoter and tumor suppressor gene BCL7A, arrested cell-cycle progress (S phases), upregulated EBV latent/lytic genes in a dose-dependent manner, stimulated EBV progeny production, activated EBV F promoter for EBV lytic activation, and suppressed EBV infection.
    CONCLUSIONS:
    These results indicated that genipin could be a promising candidate for antiviral and antitumor agents against EBV and EBVaGC.
    Biomaterials. 2013 Oct;34(31):7754-65.
    Induction of angiogenesis using VEGF releasing genipin-crosslinked electrospun gelatin mats.[Pubmed: 23863451]
    Rapid and controlled vascularization of engineered tissues remains one of the key limitations in tissue engineering applications.
    METHODS AND RESULTS:
    This study investigates the possible use of natural extracellular matrix-like scaffolds made of gelatin loaded with human vascular endothelial growth factor (VEGF), as a bioresorbable platform for long-term release and consequent angiogenic boosting. For this aim, gelatin was firstly electrospun and then cross-linked at two different concentrations (0.1% and 0.5% w/v) by using genipin, a low toxic agent, in order to fabricate a suitable substrate to be loaded with VEGF. Collected fibers were homogeneous and free of beads, the fibrous structure was retained after cross-linking. Mechanical properties were deeply affected by the chemical treatment showing a different behavior, depending on the testing conditions (i.e., dry or wet state). VEGF release was assessed by means of ELISA assay: a cumulative release of about 90% (0.1% w/v) and 60% (0.5% w/v) at 28 days was measured. Both VEGF loaded mats induced cell viability, endothelial differentiation and showed chemoattractive properties when tested on human mesenchymal stromal cells (hMSCs). In vitro and in vivo angiogenic assays demonstrated that the VEGF loaded mats induced an angiogenic potential in stimulating new vessel formation similar, if not superior, to fresh VEGF. VEGF retains bioactive and pro-angiogenic potential for up to 14 days.
    CONCLUSIONS:
    The results demonstrated that genipin cross-linked electrospun gelatin mats loaded with VEGF could be part of a useful strategy to stimulate and induce angiogenesis in tissue engineered applications.
    In vivo:
    Biochimie. 2014 Dec;107 Pt B:391-5.
    Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells.[Pubmed: 25457105]
    Genipin, the aglycon of geniposide found in gardenia fruit has long been considered for treatment of inflammatory diseases in traditional oriental medicine. Genipin has recently been reported to have some pharmacological functions, such as antimicrobial, antitumor, and anti-inflammatory effects.
    METHODS AND RESULTS:
    The aim of this study was to examine whether genipin could modify matrix metalloproteinase (MMP)-1 and MMP-3, which are related to the destruction of periodontal tissues in periodontal lesion, expression in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLCs). Genipin prevented TNF-α-mediated MMP-1 and MMP-3 productions in HPDLCs. Moreover, genipin could suppress not only extracellular signal-regulated kinase (ERK) and Jun-N-terminal kinase (JNK) phosphorylations but also AMP-activated protein kinase (AMPK) phosphorylation in TNF-α-stimulated HPDLCs. Inhibitors of ERK and AMPK could inhibit both MMP-1 and MMP-3 productions. Moreover, we revealed the ERK inhibitor suppressed AMPK phosphorylation in TNF-α-stimulated HPDLCs.
    CONCLUSIONS:
    These data provide a new mechanism through which genipin could be used for the treatment of periodontal disease to prevent MMPs expression in periodontal lesion.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4203 mL 22.1014 mL 44.2028 mL 88.4056 mL 110.507 mL
    5 mM 0.8841 mL 4.4203 mL 8.8406 mL 17.6811 mL 22.1014 mL
    10 mM 0.442 mL 2.2101 mL 4.4203 mL 8.8406 mL 11.0507 mL
    50 mM 0.0884 mL 0.442 mL 0.8841 mL 1.7681 mL 2.2101 mL
    100 mM 0.0442 mL 0.221 mL 0.442 mL 0.8841 mL 1.1051 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    京尼平; Genipin CFN99142 6902-77-8 C11H14O5 = 226.23 20mg QQ客服:2159513211
    京尼平甙; 栀子甙; Geniposide CFN98261 24512-63-8 C17H24O10 = 388.4 20mg QQ客服:215959384
    京尼平-1-O-龙胆双糖苷; Genipin-1-O-gentiobioside CFN98524 29307-60-6 C23H34O15 = 550.51 20mg QQ客服:3257982914
    黄夹苦苷; Theviridoside CFN98241 23407-76-3 C17H24O11 = 404.4 5mg QQ客服:2159513211
    鸡矢藤次苷甲酯; Feretoside CFN98330 27530-67-2 C17H24O11 = 404.4 10mg QQ客服:1413575084
    去乙酰车叶草苷酸甲酯; Deacetylasperulosidic acid methyl ester CFN92359 52613-28-2 C17H24O11 = 404.4 20mg QQ客服:2159513211
    6-乙氧基京尼平苷; 6-Ethoxygeniposide CFN96738 1264496-61-8 C19H28O11 = 432.42 5mg QQ客服:2932563308
    交让木苷; Daphylloside CFN99468 14260-99-2 C19H26O12 = 446.4 5mg QQ客服:215959384
    鸡屎藤苷甲酯; Paederosidic acid methyl ester CFN92525 122413-01-8 C19H26O12S = 478.5 10mg QQ客服:1413575084
    10-O-咖啡酰基-脱乙酰基交让木苷; 10-O-Caffeoyl-6-epiferetoside CFN97953 83348-22-5 C26H30O14 = 566.5 5mg QQ客服:2932563308

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