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  • 鸡屎藤苷甲酯

    Paederosidic acid methyl ester

    鸡屎藤苷甲酯
    产品编号 CFN92525
    CAS编号 122413-01-8
    分子式 = 分子量 C19H26O12S = 478.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The herbs of Paederia scandens (Lour.) Merr
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鸡屎藤苷甲酯 CFN92525 122413-01-8 1mg QQ客服:2159513211
    鸡屎藤苷甲酯 CFN92525 122413-01-8 5mg QQ客服:2159513211
    鸡屎藤苷甲酯 CFN92525 122413-01-8 10mg QQ客服:2159513211
    鸡屎藤苷甲酯 CFN92525 122413-01-8 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Hamdard University (India)
  • University of Beira Interior (Portugal)
  • Weizmann Institute of Science (Israel)
  • Universidad Miguel Hernández (Spain)
  • Chungnam National University (Korea)
  • Center for protein Engineering (CIP) (Belgium)
  • Macau University of Science and Technology (China)
  • University of Auckland (New Zealand)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of South Australia (Australia)
  • National Research Council of Canada (Canada)
  • Mahatma Gandhi University (India)
  • Universite de Lille1 (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Med.2015, 35(5):1237-45
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Acta Physiologiae Plantarum2016, 38:7
  • Exp Parasitol.2017, 183:160-166
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Food Chem.2018, 252:207-214
  • Exp Neurobiol.2018, 27(3):200-209
  • Sci Rep. 2018, 462(8)
  • Phytomedicine.2018, 47:48-57
  • Planta Med.2018, 84(15):1101-1109
  • Nutrients.2019, 11(11):E2694
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • Food Engineering Progress2019, 23(3)209-216
  • Molecules.2019, 24(12):E2286
  • J Ethnopharmacol.2019, 244:112074
  • Toxicol In Vitro.2019, 59:161-178
  • Phytomedicine.2019, 61:152813
  • Plos One.2019, 15(2):e0220084
  • Sci Rep.2019, 9:19059
  • Psychopharmacology (Berl).2020, 10.1007
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • J Ethnopharmacol.2020, 249:112381
  • ...
  • 生物活性
    Description: Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.
    Targets: NO | ATPase | Potassium Channel
    In vivo:
    Pharmacol Biochem Behav. 2009 Aug;93(2):97-104.
    Antinociceptive activity of Paederosidic Acid Methyl Ester (PAME) from the n-butanol fraction of Paederia scandens in mice.[Pubmed: 19409921]
    Antinociceptive activity of Paederosidic acid methyl ester (PAME), a chemical compound isolated from the n-butanol fraction of Paederia scandens, was evaluated in mice using chemical and thermal models of nociception.
    METHODS AND RESULTS:
    Paederosidic acid methyl ester given by intraperitoneal injection at doses of 20, 40 and 60 mg/kg produced significant inhibitions on chemical nociception induced by intraperitoneal acetic acid, subplantar formalin or capsaicin injections and on thermal nociception in the tail-flick test and the hot plate test. In the pentobarbital sodium-induced sleep time test and the open-field test, Paederosidic acid methyl ester neither significantly enhanced the pentobarbital sodium-induced sleep time nor impaired the motor performance, indicating that the observed antinociceptive activity of Paederosidic acid methyl ester was unlikely due to sedation or motor abnormality. Core body temperature measurement showed that Paederosidic acid methyl ester did not affect temperature within a 2-h period. Moreover, Paederosidic acid methyl ester-induced antinociception in the hot plate test was insensitive to naloxone or nimodipine but significantly antagonized by L-NAME (N (G)-nitro-L-arginine methyl ester), methylene blue and glibenclamide.
    CONCLUSIONS:
    These results suggested that Paederosidic acid methyl ester-produced antinociception was possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels, which merited further studies regarding the precise site and mechanisms of action.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0899 mL 10.4493 mL 20.8986 mL 41.7973 mL 52.2466 mL
    5 mM 0.418 mL 2.0899 mL 4.1797 mL 8.3595 mL 10.4493 mL
    10 mM 0.209 mL 1.0449 mL 2.0899 mL 4.1797 mL 5.2247 mL
    50 mM 0.0418 mL 0.209 mL 0.418 mL 0.8359 mL 1.0449 mL
    100 mM 0.0209 mL 0.1045 mL 0.209 mL 0.418 mL 0.5225 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    京尼平; Genipin CFN99142 6902-77-8 C11H14O5 = 226.23 20mg QQ客服:2159513211
    京尼平甙; 栀子甙; Geniposide CFN98261 24512-63-8 C17H24O10 = 388.4 20mg QQ客服:2932563308
    京尼平-1-O-龙胆双糖苷; Genipin-1-O-gentiobioside CFN98524 29307-60-6 C23H34O15 = 550.51 20mg QQ客服:2932563308
    黄夹苦苷; Theviridoside CFN98241 23407-76-3 C17H24O11 = 404.4 5mg QQ客服:215959384
    鸡矢藤次苷甲酯; Feretoside CFN98330 27530-67-2 C17H24O11 = 404.4 10mg QQ客服:1413575084
    去乙酰车叶草苷酸甲酯; Deacetylasperulosidic acid methyl ester CFN92359 52613-28-2 C17H24O11 = 404.4 20mg QQ客服:2932563308
    6-乙氧基京尼平苷; 6-Ethoxygeniposide CFN96738 1264496-61-8 C19H28O11 = 432.42 5mg QQ客服:1413575084
    交让木苷; Daphylloside CFN99468 14260-99-2 C19H26O12 = 446.4 5mg QQ客服:1148253675
    鸡屎藤苷甲酯; Paederosidic acid methyl ester CFN92525 122413-01-8 C19H26O12S = 478.5 10mg QQ客服:215959384
    10-O-咖啡酰基-脱乙酰基交让木苷; 10-O-Caffeoyl-6-epiferetoside CFN97953 83348-22-5 C26H30O14 = 566.5 5mg QQ客服:1148253675

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