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  • 龙脑香醇酮

    Dipterocarpol

    龙脑香醇酮
    产品编号 CFN98705
    CAS编号 471-69-2
    分子式 = 分子量 C30H50O2 = 442.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Aglaia odorata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    龙脑香醇酮 CFN98705 471-69-2 1mg QQ客服:215959384
    龙脑香醇酮 CFN98705 471-69-2 5mg QQ客服:215959384
    龙脑香醇酮 CFN98705 471-69-2 10mg QQ客服:215959384
    龙脑香醇酮 CFN98705 471-69-2 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • FEBS Lett.2015, 589(1):182-7
  • Food Research International2016, 106-113
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
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  • Nutrients.2018, 10(7)
  • Pathogens.2018, 7(3):E62
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  • Front Aging Neurosci.2019, 11:230
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  • BMC Complement Altern Med.2019, 19(1):325
  • Int J Mol Sci.2019, 20(16):E4015
  • J Ethnopharmacol.2019, 228:132-141
  • Molecules.2019, 24(20):3755
  • J Ethnopharmacol.2019, 241:112025
  • Saudi Pharm J.2019, 27(1):145-153
  • Food Chem.2019, 290:286-294
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  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • J Food Biochem.2019, 43(9):e12970
  • ...
  • 生物活性
    Description: Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory activity with the IC50 value of 8.28 uM.
    Targets: P450 (e.g. CYP17) | AChE
    In vitro:
    FEBS J. 2012 May;279(9):1663-74.
    Hydroxylation of the triterpenoid dipterocarpol with CYP106A2 from Bacillus megaterium.[Pubmed: 22269065]
    Namely Dipterocarpol and betulin. Dipterocarpol is the most promising compound for biotechnological application because it is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng.
    METHODS AND RESULTS:
    The Dipterocarpol hydroxylation products were analysed by NMR and identified as 7β-hydroxyDipterocarpol and 7β,11α-dihydroxyDipterocarpol. To investigate the putative bioactive properties of these novel compounds, in vitro cytotoxicity assays with HeLa and COS-1 cells were performed. The substrate Dipterocarpol and the dihydroxylated product did not show cytotoxic activity in our study. By contrast, the 7β-hydroxylated product was found to be cytotoxic to both tested cell lines.
    CONCLUSIONS:
    This study highlights the potency of CYP106A2 as a versatile biocatalyst for the bioconversion of natural products into pharmaceutically relevant bioactive products.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2589 mL 11.2943 mL 22.5887 mL 45.1773 mL 56.4717 mL
    5 mM 0.4518 mL 2.2589 mL 4.5177 mL 9.0355 mL 11.2943 mL
    10 mM 0.2259 mL 1.1294 mL 2.2589 mL 4.5177 mL 5.6472 mL
    50 mM 0.0452 mL 0.2259 mL 0.4518 mL 0.9035 mL 1.1294 mL
    100 mM 0.0226 mL 0.1129 mL 0.2259 mL 0.4518 mL 0.5647 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    达玛烯二醇 II 3-O-咖啡酸酯; Dammarenediol II 3-O-caffeate CFN96254 171438-55-4 C39H58O5 = 606.9 5mg QQ客服:2932563308
    龙脑香醇酮; Dipterocarpol CFN98705 471-69-2 C30H50O2 = 442.7 5mg QQ客服:1148253675
    20,24-二羟基达玛-25-烯-3-酮; 20,24-Dihydroxydammar-25-en-3-one CFN97232 75069-59-9 C30H50O3 = 458.7 5mg QQ客服:2932563308
    (24S)-24,25-环氧达玛树脂-20-烯-3-酮; 24,25-Epoxydammar-20(21)-en-3-one CFN97092 63543-52-2 C30H48O2 = 440.7 5mg QQ客服:215959384
    达玛树脂-20(21)-烯-3,24,25-三醇; Dammar-20(21)-en-3,24,25-triol CFN98922 55050-69-6 C30H52O3 = 460.7 5mg QQ客服:1148253675
    24,25-二羟基达马树脂-20-烯-3-酮; 24,25-Dihydroxydammar-20-en-3-one CFN97093 63543-53-3 C30H50O3 = 458.7 5mg QQ客服:2932563308
    25(R)-羟基原人参二醇; 25(R)-Hydroxyprotopanaxadiol CFN90349 83349-37-5 C30H54O4 = 478.75 5mg QQ客服:1148253675
    25(S)-羟基原人参三醇; 25(S)-Hydroxyprotopanaxatriol CFN90351 113539-03-0 C30H54O5 = 494.75 5mg QQ客服:2932563308
    绞股蓝皂苷XLIX; Gypenoside XLIX CFN99717 94987-08-3 C52H86O21 = 1047.23 20mg QQ客服:1148253675
    芍药二酮; Palbinone CFN96019 139954-00-0 C22H30O4 = 358.5 5mg QQ客服:1148253675

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