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  • 绞股蓝皂苷XLIX

    Gypenoside XLIX

    绞股蓝皂苷XLIX
    产品编号 CFN99717
    CAS编号 94987-08-3
    分子式 = 分子量 C52H86O21 = 1047.23
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Gynostemma pentaphyllum (Thunb.) Makino.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    绞股蓝皂苷XLIX CFN99717 94987-08-3 10mg QQ客服:1457312923
    绞股蓝皂苷XLIX CFN99717 94987-08-3 20mg QQ客服:1457312923
    绞股蓝皂苷XLIX CFN99717 94987-08-3 50mg QQ客服:1457312923
    绞股蓝皂苷XLIX CFN99717 94987-08-3 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Charles Sturt University (Denmark)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Mahatma Gandhi University (India)
  • John Innes Centre (United Kingdom)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Liège (Belgium)
  • University of Medicine and Pharmacy (Romania)
  • University of Amsterdam (Netherlands)
  • University of Parma (Italy)
  • Universite Libre de Bruxelles (Belgium)
  • Universidad de Buenos Aires (Argentina)
  • University of Auckland (New Zealand)
  • University of Cincinnati (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Institute of Food Science & Technology2021, 18 December.
  • Emirates Journal of Food and Agriculture.2022, 34(6): 528-536.
  • Fitoterapia.2022, 105141.
  • Aquaculture2017, 481:94-102
  • Molecules2022, 27(9):2827.
  • Inflammation.2015, 38(4):1502-16
  • Molecules.2019, 24(1):E159
  • Exp Parasitol.2017, 183:160-166
  • Molecules2022, 27(12):3903.
  • J Funct Foods2019, 54:449-456
  • Int J Cosmet Sci.2019, 41(1):12-20
  • Phytomedicine.2019, 56:48-56
  • Biosci Biotechnol Biochem.2021, 85(10):2153-2160.
  • Int Immunopharmacol.2021, 100:108073.
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • Int J Mol Sci.2022, 23(21):12816.
  • Phytochemistry Letters2017, 449-455
  • Pharmacia2022, 69(3): 883-890.
  • Neurotox Res.2020, 38(1):163-174.
  • Molecules.2019, 24(10):E1926
  • Oncotarget.2017, 9(3):4161-4172
  • Rev. Chim.2020, 71(3),558-564
  • ...
  • 生物活性
    Description: Gypenoside XLIX, a naturally occurring gynosaponin, inhibits NF-kappaB activation via a PPAR-alpha-dependent pathway, it may treat inflammatory and cardiovascular diseases, including atherosclerosis.
    Targets: PPAR | TNF-α | NF-kB | p65
    In vitro:
    J Biomed Sci. 2006 Jul;13(4):535-48.
    Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway.[Pubmed: 16525884]
    Nuclear factor (NF)-kappaB is important in the generation of inflammation. Besides regulating lipid metabolism, peroxisome proliferator-activated receptor (PPAR)-alpha activators also reduce NF-kappaB activation to terminate activation of inflammatory pathways. Gynostemma pentaphyllum (GP) has been used to treat various inflammatory diseases and hyperlipidemia.
    METHODS AND RESULTS:
    Here, we demonstrate that GP extract and one of its main components, Gypenoside XLIX (Gyp-XLIX) inhibited LPS-induced NF-kappaB activation in murine macrophages. Furthermore, Gyp-XLIX restored the LPS- and TNF-alpha-induced decrease in cytosolic I-kappaBalpha protein expression and inhibited the translocation of NF-kappaB(p65) to the nucleus in THP-1 monocyte and HUVEC cells. The inhibition of LPS- and TNF-alpha-induced NF-kappaB luciferase activity in macrophages was abolished by MK-886, a selective PPAR-alpha antagonist. GP extract and Gyp-XLIX (EC(50): 10.1 microM) enhanced PPAR-alpha luciferase activity in HEK293 cells transfected with the tK-PPREx3-Luc reporter plasmid and expression vectors for PPAR-alpha. Additionally, Gyp-XLIX specifically enhanced PPAR-alpha mRNA and protein expression in THP-1-derived macrophage cells. The selectivity of Gyp-XLIX for PPAR-alpha was demonstrated by the activation of only PPAR-alpha in HEK293 cells transfected with expression vectors for PPAR-alpha, PPAR-beta/delta or PPAR-gamma1 plasmids and in THP-1-derived macrophage naturally expressing all three PPAR isoforms.
    CONCLUSIONS:
    The present study demonstrates that Gyp-XLIX, a naturally occurring gynosaponin, inhibits NF-kappaB activation via a PPAR-alpha-dependent pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9549 mL 4.7745 mL 9.549 mL 19.098 mL 23.8725 mL
    5 mM 0.191 mL 0.9549 mL 1.9098 mL 3.8196 mL 4.7745 mL
    10 mM 0.0955 mL 0.4775 mL 0.9549 mL 1.9098 mL 2.3873 mL
    50 mM 0.0191 mL 0.0955 mL 0.191 mL 0.382 mL 0.4775 mL
    100 mM 0.0095 mL 0.0477 mL 0.0955 mL 0.191 mL 0.2387 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    绞股蓝皂苷XLIX; Gypenoside XLIX CFN99717 94987-08-3 C52H86O21 = 1047.23 20mg QQ客服:1413575084
    芍药二酮; Palbinone CFN96019 139954-00-0 C22H30O4 = 358.5 5mg QQ客服:3257982914
    达玛烯二醇 II 3-O-咖啡酸酯; Dammarenediol II 3-O-caffeate CFN96254 171438-55-4 C39H58O5 = 606.9 5mg QQ客服:1457312923
    龙脑香醇酮; Dipterocarpol CFN98705 471-69-2 C30H50O2 = 442.7 5mg QQ客服:1457312923
    20,24-二羟基达玛-25-烯-3-酮; 20,24-Dihydroxydammar-25-en-3-one CFN97232 75069-59-9 C30H50O3 = 458.7 5mg QQ客服:3257982914
    (24S)-24,25-环氧达玛树脂-20-烯-3-酮; 24,25-Epoxydammar-20(21)-en-3-one CFN97092 63543-52-2 C30H48O2 = 440.7 5mg QQ客服:2056216494
    达玛树脂-20(21)-烯-3,24,25-三醇; Dammar-20(21)-en-3,24,25-triol CFN98922 55050-69-6 C30H52O3 = 460.7 5mg QQ客服:215959384
    24,25-二羟基达马树脂-20-烯-3-酮; 24,25-Dihydroxydammar-20-en-3-one CFN97093 63543-53-3 C30H50O3 = 458.7 5mg QQ客服:2056216494
    25(R)-羟基原人参二醇; 25(R)-Hydroxyprotopanaxadiol CFN90349 83349-37-5 C30H54O4 = 478.75 5mg QQ客服:1457312923
    25(S)-羟基原人参三醇; 25(S)-Hydroxyprotopanaxatriol CFN90351 113539-03-0 C30H54O5 = 494.75 5mg QQ客服:2159513211

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