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  • 去氢木香内酯

    Dehydrocostus lactone

    去氢木香内酯
    产品编号 CFN98720
    CAS编号 477-43-0
    分子式 = 分子量 C15H18O2 = 230.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Saussurea lappa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    去氢木香内酯 CFN98720 477-43-0 10mg QQ客服:1413575084
    去氢木香内酯 CFN98720 477-43-0 20mg QQ客服:1413575084
    去氢木香内酯 CFN98720 477-43-0 50mg QQ客服:1413575084
    去氢木香内酯 CFN98720 477-43-0 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Wisconsin-Madison (USA)
  • National Cancer Institute (USA)
  • University of British Columbia (Canada)
  • Mahidol University (Thailand)
  • Center for protein Engineering (CIP) (Belgium)
  • The Institute of Cancer Research (United Kingdom)
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  • Medizinische Universit?t Wien (Austria)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • University of Illinois (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11(43):562-6
  • HortTechnology2016, 26(6):816-819
  • Oncotarget.2016, 8(51):88386-88400
  • Research on Crops.2017, 18(2)
  • J Ethnopharmacol.2017, 198:205-213
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Neurochem Int.2018, 121:114-124
  • Exp Neurobiol.2018, 27(3):200-209
  • Phytomedicine.2018, 40:37-47
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Mol Cells.2018, 41(8):771-780
  • Sci Rep.2018, 8(1)
  • Front Pharmacol.2018, 9:236
  • BMC Complement Altern Med.2019, 19(1):11
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Molecules.2019, 24(20):3755
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Academic J of Second Military Medical University2019, 40(1)
  • TCI CO.2019, US20190151257A1
  • Biomolecules.2020, 10(2):E184
  • Food Funct.2020, 10.1039
  • ...
  • 生物活性
    Description: Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ, Wnt/β-catenin activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. DHE has anti-inflammatory, antioxidant, anti-ulcer, immunomodulatory and anti-tumor properties, it can against osteoblast damage induced by AMA and cervical cancer. DHE exhibits strong larvicidal activity against A. albopictus with LC(50) values of 2.34 ug/ml.
    Targets: Wnt/β-catenin | PI3K | Akt | PKB | Caspase | PARP | HO-1 | Nrf2 | Antifection | IκB/IKK, | COX | NF-κB
    In vitro:
    Phytother Res. 2015 May;29(5):680-6.
    Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells.[Pubmed: 25625870]
    Abnormal activation of β-catenin has been reported in 90% in the sporadic and hereditary colorectal cancer. The suppression of abnormally activated β-catenin is one of the good strategies for chemoprevention and treatment of colorectal cancer.
    METHODS AND RESULTS:
    In this study, we have isolated two main compounds from root of Saussurea lappa, dehydrocostus lactone (DCL) and costunolide (CL), and investigated their anti-colorectal cancer activities. DCL and CL suppressed cyclin D1 and survivin through inhibiting nuclear translocation of β-catenin. They also suppressed the nuclear translocation of galectin-3 that is one of the coactivators of β-catenin in SW-480 colon cancer cells. Furthermore, DCL and CL suppressed proliferation and survival of SW-480 colon cancer cells through the induction of cell cycle arrest and cell death.
    CONCLUSIONS:
    Taken together, DCL and CL from root of S. lappa have anti-colorectal cancer activities through inhibiting Wnt/β-catenin pathway.
    Planta Med. 2012 Nov;78(16):1749-56.
    Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells.[Pubmed: 23047249]
    Human soft tissue sarcomas represent a rare group of malignant tumours that frequently exhibit chemotherapeutic resistance and increased metastatic potential following unsuccessful treatment.
    METHODS AND RESULTS:
    In this study, we investigated the effects of costunolide and dehydrocostus lactone, which have been isolated from Saussurea lappa using activity-guided isolation, on three soft tissue sarcoma cell lines of various origins. The effects on cell proliferation, cell cycle distribution, apoptosis induction, and ABC transporter expression were analysed. Both compounds inhibited cell viability dose- and time-dependently. IC50 values ranged from 6.2 μg/mL to 9.8 μg/mL. Cells treated with costunolide showed no changes in cell cycle, little in caspase 3/7 activity, and low levels of cleaved caspase-3 after 24 and 48 h. Dehydrocostus lactone caused a significant reduction of cells in the G1 phase and an increase of cells in the S and G2/M phase. Moreover, it led to enhanced caspase 3/7 activity, cleaved caspase-3, and cleaved PARP indicating apoptosis induction. In addition, the influence of costunolide and dehydrocostus lactone on the expression of ATP binding cassette transporters related to multidrug resistance (ABCB1/MDR1, ABCC1/MRP1, and ABCG2/BCRP1) was examined using real-time RT-PCR. The expressions of ABCB1/MDR1 and ABCG2/BCRP1 in liposarcoma and synovial sarcoma cells were significantly downregulated by dehydrocostus lactone.
    CONCLUSIONS:
    Our data demonstrate for the first time that dehydrocostus lactone affects cell viability, cell cycle distribution and ABC transporter expression in soft tissue sarcoma cell lines. Furthermore, it led to caspase 3/7 activity as well as caspase-3 and PARP cleavage, which are indicators of apoptosis. Therefore, this compound may be a promising lead candidate for the development of therapeutic agents against drug-resistant tumours.
    Parasitol Res. 2012 Jun;110(6):2125-30.
    Essential oil composition and larvicidal activity of Saussurea lappa roots against the mosquito Aedes albopictus (Diptera: Culicidae).[Pubmed: 22167373 ]
    In recent years, uses of environment friendly and biodegradable natural insecticides of plant origin have received renewed attention as agents for vector control.
    METHODS AND RESULTS:
    The aim of this research was to determine larvicidal activity of the essential oil derived from roots of Saussurea lappa (Compositae) and the isolated constituents against the larvae of the Culicidae mosquito Aedes albopictus. Essential oil of S. lappa roots was obtained by hydrodistillation and analyzed by gas chromatography (GC) and GC-mass spectrometry (MS). A total of 39 components of the essential oil of S. lappa roots were identified. The essential oil has higher content of (79.80%) of sesquiterpenoids than monoterpenoids (13.25%). The principal compounds in S. lappa essential oil were dehydrocostus lactone (46.75%), costunolide (9.26%), 8-cedren-13-ol (5.06%), and α-curcumene (4.33%). Based on bioactivity-directed fractionation, dehydrocostus lactone and costunolide were isolated from S. lappa essential oil. Dehydrocostus lactone and costunolide exhibited strong larvicidal activity against A. albopictus with LC(50) values of 2.34 and 3.26 μg/ml, respectively, while the essential oil had an LC(50) value of 12.41 μg/ml.
    CONCLUSIONS:
    The result indicated that the essential oil of S. lappa and the two isolated constituents have potential for use in control of A. albopictus larvae and could be useful in search of newer, safer and more effective natural compounds as larvicides.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.3422 mL 21.7108 mL 43.4216 mL 86.8432 mL 108.5541 mL
    5 mM 0.8684 mL 4.3422 mL 8.6843 mL 17.3686 mL 21.7108 mL
    10 mM 0.4342 mL 2.1711 mL 4.3422 mL 8.6843 mL 10.8554 mL
    50 mM 0.0868 mL 0.4342 mL 0.8684 mL 1.7369 mL 2.1711 mL
    100 mM 0.0434 mL 0.2171 mL 0.4342 mL 0.8684 mL 1.0855 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1beta,10beta-Epoxydesacetoxymatricarin; 1beta,10beta-Epoxydesacetoxymatricarin CFN89005 124020-39-9 C15H18O4 = 262.30 5mg QQ客服:1148253675
    Artemyriantholide D; Artemyriantholide D CFN89190 421558-76-1 C30H36O6 = 492.61 5mg QQ客服:1148253675
    去氢木香内酯; Dehydrocostus lactone CFN98720 477-43-0 C15H18O2 = 230.3 20mg QQ客服:1413575084
    磺酸基木香烯内酯A; Sulfocostunolide A CFN99030 1016983-51-9 C15H20O5S = 312.4 5mg QQ客服:1413575084
    磺酸基木香烯内酯B; Sulfocostunolide B CFN99075 1059671-65-6 C15H20O5S = 312.4 5mg QQ客服:2159513211
    1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide; 1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide CFN89195 221148-94-3 C15H20O5 = 280.32 5mg QQ客服:1148253675
    林泽兰内酯B; Eupalinilide B CFN90378 757202-08-7 C20H24O6 = 360.41 10mg QQ客服:1413575084
    林泽兰内酯C; Eupalinilide C CFN90379 757202-11-2 C20H24O7 = 376.4 5mg QQ客服:3257982914
    林泽兰内酯D; Eupalinilide D CFN90380 757202-14-5 C15H19ClO5 = 314.76 10mg QQ客服:1413575084
    8-Epicrepiside E; 8-Epicrepiside E CFN96796 93395-30-3 C21H28O9 = 424.44 5mg QQ客服:3257982914

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