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  • 菜蓟苦素

    Cynaropicrin

    菜蓟苦素
    产品编号 CFN93077
    CAS编号 35730-78-0
    分子式 = 分子量 C19H22O6 = 346.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The leaves of Cynara scolymus L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    菜蓟苦素 CFN93077 35730-78-0 1mg QQ客服:3257982914
    菜蓟苦素 CFN93077 35730-78-0 5mg QQ客服:3257982914
    菜蓟苦素 CFN93077 35730-78-0 10mg QQ客服:3257982914
    菜蓟苦素 CFN93077 35730-78-0 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas Airlangga (Indonesia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Universidad de La Salle (Mexico)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Wuerzburg (Germany)
  • Auburn University (USA)
  • University of Toronto (Canada)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Lodz (Poland)
  • Indian Institute of Science (India)
  • University of Vienna (Austria)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • The Australian National University (Australia)
  • Semmelweis Unicersity (Hungary)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Antibiotics.2022, 11(4), 510.
  • Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
  • Food Chem Toxicol.2023, 176:113785.
  • Int J Mol Sci.2022, 23(21):13406.
  • Anal Chim Acta.2018, 1039:162-171
  • Phytomedicine.2022, 102:154183.
  • The Japan Society for Analytical Chemistry2017, 613-617
  • Foods.2021, 10(6):1378.
  • Bioengineering2023, 10(10), 1113.
  • Research on Crops.2017, 18(3):569
  • Arch Biochem Biophys.2018, 644:93-99
  • Food and Fermentation Industries2018, 44(371)
  • Antioxidants (Basel).2020, 9(11):1121.
  • J Pharm Biomed Anal.2017, 140:274-280
  • Plant Pathology2022, 10.1111:ppa.13651.
  • University of Limpopo2016, 1-237
  • The Korea Journal of Herbology2020, 35(3):33-45.
  • J Agric Food Chem.2015, 63(44):9869-78
  • Trop J Pharm Res.2023, 22(3):283-288.
  • Appl. Sci.2023, 13(17), 9653.
  • Plants (Basel).2022, 11(21):2947.
  • Acta Chromatographica2016, 29(3)
  • ...
  • 生物活性
    Description: Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro-apoptotic activity. Cynaropicrin shows in vivo activity against Trypanosoma brucei. Cynaropicrin possesses immunomodulatory effects on cytokine release, nitric oxide production and immunosuppressive effects. Cynaropicrin also has anti-inflammatory effects, it may participate in the inflammatory response by inhibiting the production of inflammatory mediators and the proliferation of lymphocytes and its inhibitory effect is mediated through conjugation with sulphydryl groups of target protein(s).
    Targets: TNF-α | NO | IL Receptor | PKC | NADPH-oxidase | Nrf2
    In vitro:
    Eur J Pharmacol. 2000 Jun 23;398(3):399-407.
    In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa.[Pubmed: 10862830]
    We investigated in vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone from Saussurea lappa, on tumor necrosis factor (TNF)-alpha and nitric oxide (NO) release, and lymphocyte proliferation.
    METHODS AND RESULTS:
    Cynaropicrin strongly inhibited TNF-alpha release from lipopolysaccharide-stimulated murine macrophage, RAW264.7 cells, and differentiated human macrophage, U937 cells, proved to produce notable amount of TNF-alpha. It also potently attenuated the accumulation of NO released from lipopolysaccharide- and interferon-gamma-stimulated RAW264.7 cells in a dose-dependent manner. In addition, the immunosuppressive effects of the compound on lymphocyte proliferation in response to mitogenic stimuli were examined. Cynaropicrin also dose-dependently suppressed the proliferation of lymphocytes from splenocytes and interleukin-2-sensitive cytotoxic T lymphocyte, CTLL-2 cells, stimulated by lipopolysaccharide, concanavalin A, phytohemagglutinin and interleukin-2. However, treatment with sulphydryl compound, L-cysteine, abrogated all these inhibitory effects.
    CONCLUSIONS:
    These results suggest that cynaropicrin may participate in the inflammatory response by inhibiting the production of inflammatory mediators and the proliferation of lymphocytes and its inhibitory effect is mediated through conjugation with sulphydryl groups of target protein(s).
    In vivo:
    Planta Med. 2012 Apr;78(6):553-6.
    Cynaropicrin: the first plant natural product with in vivo activity against Trypanosoma brucei.[Pubmed: 22331812 ]
    A screen of 1800 plant and fungal extracts with subsequent HPLC-based activity profiling was done to identify new antiprotozoal leads from nature.
    METHODS AND RESULTS:
    This led to the identification of Cynaropicrin (1) from the herb CENTAUREA SALMANTICA L. (Asteraceae) as a potent IN VITRO inhibitor of TRYPANOSOMA BRUCEI RHODESIENSE. It preferentially inhibited T. B. RHODESIENSE (IC (50) of 0.3 μM) and T. BRUCEI GAMBIENSE (IC (50) of 0.2 μM), compared to TRYPANOSOMA CRUZI (IC (50) of 4.4 μM) and PLASMODIUM FALCIPARUM (IC (50) of 3.0 μM). Testing against melarsoprol- and pentamidine-resistant strains (IC (50)s of 0.3 μM and 0.1 μM, respectively) showed no cross-resistance. Intraperitoneal administration of 2 × 10 mg/kg body weight/day in the T. B. RHODESIENSE STIB 900 acute mouse model led to a 92 % reduction of parasitemia compared to untreated controls on day seven post-infection. Removal of the 2-hydroxymethyl-2-propenoyl moiety of Cynaropicrin led to a loss of toxicity towards T. B. RHODESIENSE. Cytotoxicities against rat myoblasts (L6 cells), human colon adenocarcinoma cells, and murine peritoneal macrophages were measured, and selectivity indices of 7.8, 62, and 9.5 were determined.
    CONCLUSIONS:
    This is the first report of a plant natural product with potent IN VIVO activity against TRYPANOSOMA BRUCEI.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8871 mL 14.4354 mL 28.8709 mL 57.7417 mL 72.1772 mL
    5 mM 0.5774 mL 2.8871 mL 5.7742 mL 11.5483 mL 14.4354 mL
    10 mM 0.2887 mL 1.4435 mL 2.8871 mL 5.7742 mL 7.2177 mL
    50 mM 0.0577 mL 0.2887 mL 0.5774 mL 1.1548 mL 1.4435 mL
    100 mM 0.0289 mL 0.1444 mL 0.2887 mL 0.5774 mL 0.7218 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去氢木香内酯; Dehydrocostus lactone CFN98720 477-43-0 C15H18O2 = 230.3 20mg QQ客服:215959384
    磺酸基木香烯内酯A; Sulfocostunolide A CFN99030 1016983-51-9 C15H20O5S = 312.4 5mg QQ客服:3257982914
    磺酸基木香烯内酯B; Sulfocostunolide B CFN99075 1059671-65-6 C15H20O5S = 312.4 5mg QQ客服:3257982914
    1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide; 1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide CFN89195 221148-94-3 C15H20O5 = 280.32 5mg QQ客服:1413575084
    林泽兰内酯B; Eupalinilide B CFN90378 757202-08-7 C20H24O6 = 360.41 10mg QQ客服:2056216494
    林泽兰内酯C; Eupalinilide C CFN90379 757202-11-2 C20H24O7 = 376.4 5mg QQ客服:2159513211
    林泽兰内酯D; Eupalinilide D CFN90380 757202-14-5 C15H19ClO5 = 314.76 10mg QQ客服:2056216494
    8-Epicrepiside E; 8-Epicrepiside E CFN96796 93395-30-3 C21H28O9 = 424.44 5mg QQ客服:3257982914
    菜蓟苦素; Cynaropicrin CFN93077 35730-78-0 C19H22O6 = 346.37 5mg QQ客服:2159513211
    (2R)-2-羟基-2-甲基-3-氧代丁酸(3aR,4R,6aR,8S,9aR,9bR)-8-(beta-D-吡喃葡萄糖基氧基)十二氢-3,6,9-三(亚甲基)-2-氧代薁并[4,5-b]呋喃-4-基酯; 8beta-(2-Hydroxy-2-methyl-3-oxobutyryloxy)glucozaluzanin C CFN96392 93395-31-4 C26H34O12 = 538.6 5mg QQ客服:2159513211

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