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  • 葫芦二烯醇

    Cucurbitadienol

    葫芦二烯醇
    产品编号 CFN92378
    CAS编号 35012-08-9
    分子式 = 分子量 C30H50O = 426.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fresh fruits of Momordica charantia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    葫芦二烯醇 CFN92378 35012-08-9 1mg QQ客服:2159513211
    葫芦二烯醇 CFN92378 35012-08-9 5mg QQ客服:2159513211
    葫芦二烯醇 CFN92378 35012-08-9 10mg QQ客服:2159513211
    葫芦二烯醇 CFN92378 35012-08-9 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Vienna (Austria)
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  • University of Wuerzburg (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Inflammation.2015, 38(4):1502-16
  • University of Limpopo2016, 1-237
  • Nat Prod Sci.2016, 22(2)
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Research on Crops.2017, 18(3):569
  • International. J. of Food Properties 2017, 20:S131-S140
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Biol Pharm Bull.2017, 40(6):797-806
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Lab Chip.2018, 18(6):971-978
  • Int J Mol Sci.2018, 19(9):E2528
  • Molecules.2018, 23(7):E1659
  • Molecules.2018, 23(9):E2121
  • Food Chem.2018, 262:78-85
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Planta Med.2018, 84(15):1101-1109
  • Nutrients.2019, 11(4):E936
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Int J Mol Sci.2019, 20(9):E2244
  • Molecules.2019, 24(4):E744
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Front Plant Sci.2020, 10:1705
  • ...
  • 生物活性
    Description: Cucurbitadienol has significant anti-inflammatory, anti-tumor effect, is also CucurbitacinBE compounds biosynthesis the key intermediate. Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloartenol synthase for phytosterol biosynthesis. CYP87D18 catalyzed the oxidation of cucurbitadienol at C-11 to produce 11-oxo cucurbitadienol and 11-hydroxy cucurbitadienol.
    Targets: Immunology & Inflammation related
    In vitro:
    Plant Cell Physiol. 2015 Mar 9.
    Functional Characterization of Cucurbitadienol Synthase and Triterpene Glycosyltransferase Involved in Biosynthesis of Mogrosides from Siraitia grosvenorii.[Pubmed: 25759326]
    Hexahydrocurcumin, 1-Dehydro-6-gingerdione, 6-dehydroshogaol and 6-shogaol were evaluated for their antioxidant and anti-inflammatory activities in the present study.
    METHODS AND RESULTS:
    The relative antioxidant potencies of ginger compounds decreased in similar order of 1-Dehydro-6-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays. All tested compounds could attenuate lipopolysaccharide (LPS)-elicited increase of prostaglandin E2 (PGE(2)) in murine macrophages (RAW 264.7) in a concentration-dependent manner but hexahydrocurcumin of 7μM and 6-shogaol of 7μM. The strongest inhibitory effect was observed for 6-dehydroshogaol and 6-shogaol at 14μM with the inhibition of 53.3% and 48.9%, respectively. Furthermore, both 6-dehydroshogaol and 1-Dehydro-6-gingerdione significantly suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion.
    CONCLUSIONS:
    These results contribute to our theoretical understanding of the potential beneficial effects of consuming ginger as a food and/or dietary supplement.
    Plant Cell Physiol., 2016,57(5):1000-7.
    Oxidation of Cucurbitadienol Catalyzed by CYP87D18 in the Biosynthesis of Mogrosides from Siraitia grosvenorii.[Pubmed: 26903528 ]
    Mogrosides, the principally bioactive compounds extracted from the fruits of Siraitia grosvenorii, are a group of glycosylated cucurbitane-type tetracyclic triterpenoid saponins that exhibit a wide range of notable biological activities and are commercially available worldwide as natural sweeteners. The biosynthesis of mogrosides involves initial cyclization of 2,3-oxidosqualene to the triterpenoid skeleton of Cucurbitadienol, followed by a series of oxidation reactions catalyzed by Cyt P450s (P450s) and then glycosylation reactions catalyzed by UDP glycosyltransferases (UGTs). We previously reported the identification of a Cucurbitadienol synthase (SgCbQ) and a mogrol C-3 hydroxyl glycosyltransferase (UGT74AC1). However, molecular characterization of further transformation of Cucurbitadienol to mogrol by P450s remains unavailable.
    METHODS AND RESULTS:
    In this study, we report the successful identification of a multifunctional P450 (CYP87D18) as being involved in C-11 oxidation of Cucurbitadienol. In vitro enzymatic activity assays showed that CYP87D18 catalyzed the oxidation of Cucurbitadienol at C-11 to produce 11-oxo Cucurbitadienol and 11-hydroxy Cucurbitadienol. Furthermore, 11-oxo-24,25-epoxy Cucurbitadienol as well as 11-oxo Cucurbitadienol and 11-hydroxy Cucurbitadienol were produced when CYP87D18 was co-expressed with SgCbQ in genetic yeast, and their structures were confirmed by liquid chromatography-solid-phase extraction-nuclear magnetic resonance-mass spectrometry coupling (LC-SPE-NMR-MS).
    CONCLUSIONS:
    Taken together, these results suggest a role for CYP87D18 as a multifunctional Cucurbitadienol oxidase in the mogrosides pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3436 mL 11.7178 mL 23.4357 mL 46.8713 mL 58.5892 mL
    5 mM 0.4687 mL 2.3436 mL 4.6871 mL 9.3743 mL 11.7178 mL
    10 mM 0.2344 mL 1.1718 mL 2.3436 mL 4.6871 mL 5.8589 mL
    50 mM 0.0469 mL 0.2344 mL 0.4687 mL 0.9374 mL 1.1718 mL
    100 mM 0.0234 mL 0.1172 mL 0.2344 mL 0.4687 mL 0.5859 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    16α-羟基松苓新酸; 16alpha-Hydroxydehydrotrametenolic acid CFN90790 176390-66-2 C30H46O4 = 470.7 10mg QQ客服:3257982914
    3-O-乙酰基-16α-羟基松苓新酸; 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid CFN90791 168293-14-9 C32H48O5 = 512.7 10mg QQ客服:2932563308
    茯苓酸B; Poricoic acid B CFN95050 137551-39-4 C30H44O5 = 484.7 10mg QQ客服:3257982914
    茯苓酸G; Poricoic acid G CFN95056 415724-84-4 C30H46O5 = 486.7 5mg QQ客服:3257982914
    大戟二烯醇; Euphol CFN89516 514-47-6 C30H50O = 426.71 10mg QQ客服:1148253675
    羊毛甾醇; Lanosterol CFN92368 79-63-0 C30H50O = 426.7 5mg QQ客服:1413575084
    丁酰鲸鱼醇; Butyrospermol CFN92376 472-28-6 C30H50O = 426.7 5mg QQ客服:1413575084
    苦楝酮; Kulinone CFN92977 21688-61-9 C30H48O2 = 440.70 5mg QQ客服:3257982914
    Aphagranin A ; Aphagranin A CFN96579 1318173-53-3 C33H54O6 = 546.79 5mg QQ客服:215959384
    金钱松呋喃酸; Pseudolarifuroic acid CFN91924 130825-79-5 C30H42O4 = 466.65 5mg QQ客服:1148253675

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