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  • 苦楝萜酸甲酯

    Methyl kulonate

    苦楝萜酸甲酯
    产品编号 CFN92975
    CAS编号 22611-37-6
    分子式 = 分子量 C31H48O4 = 484.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The seeds of Melia toosendan
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苦楝萜酸甲酯 CFN92975 22611-37-6 1mg QQ客服:3257982914
    苦楝萜酸甲酯 CFN92975 22611-37-6 5mg QQ客服:3257982914
    苦楝萜酸甲酯 CFN92975 22611-37-6 10mg QQ客服:3257982914
    苦楝萜酸甲酯 CFN92975 22611-37-6 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Worcester Polytechnic Institute (USA)
  • University of Illinois at Chicago (USA)
  • Weizmann Institute of Science (Israel)
  • University of Leipzig (Germany)
  • Technical University of Denmark (Denmark)
  • St. Jude Children Research Hospital (USA)
  • MTT Agrifood Research Finland (Finland)
  • Cornell University (USA)
  • Indian Institute of Science (India)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • University of Mysore (India)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Amsterdam (Netherlands)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11:S585-91
  • Int J Mol Sci.2015, 16(8):18396-411
  • Tumour Biol.2015, 36(12):9385-93
  • J Agric Food Chem.2015, 63(44):9869-78
  • J Drug Target.2016, 24:1-28
  • Oncol Rep.2016, 35(3):1356-64
  • Molecules.2017, 22(2)
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • J Cell Biochem.2018, 119(2):2231-2239
  • Int J Mol Sci.2018, 19(9):E2601
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Cell Biochem Funct.2018, 36(6):303-311
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Oncology Letters2018, 4690-4696
  • Sci Rep.2018, 8:9267
  • Front Pharmacol.2018, 9:236
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Molecules.2019, 24(22):E4022
  • FASEB J.2019, 33(8):9685-9694
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • J Sep Sci.2020, 201901140
  • ...
  • 生物活性
    Description: Methyl kulonate shows interesting antimycobacterial activity (with MIC value of 70 uM ). Methyl kulonate exhibits potent cytotoxicities against HL60 cells with IC50 values in the range of 2.8-5.8 uM.It inhibits production of nitric oxide (NO) in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide (LPS).
    Targets: NO | NOS | COX | Antifection
    In vitro:
    PLoS One. 2015 Oct 20;10(10):e0141272.
    Limonoids from Melia azedarach Fruits as Inhibitors of Flaviviruses and Mycobacterium tubercolosis.[Pubmed: 26485025]
    The biological diversity of nature is the source of a wide range of bioactive molecules. The natural products, either as pure compounds or as standardized plant extracts, have been a successful source of inspiration for the development of new drugs. The present work was carried out to investigate the cytotoxicity, antiviral and antimycobacterial activity of the methanol extract and of four identified limonoids from the fruits of Melia azedarach (Meliaceae).
    METHODS AND RESULTS:
    The extract and purified limonoids were tested in cell-based assays for antiviral activity against representatives of ssRNA, dsRNA and dsDNA viruses and against Mycobacterium tuberculosis. Very interestingly, 3-α-tigloyl-melianol and melianone showed a potent antiviral activity (EC50 in the range of 3-11μM) against three important human pathogens, belonging to Flaviviridae family, West Nile virus, Dengue virus and Yellow Fever virus. Mode of action studies demonstrated that title compounds were inhibitors of West Nile virus only when added during the infection, acting as inhibitors of the entry or of a very early event of life cycle. Furthermore, 3-α-tigloyl-melianol and Methyl kulonate showed interesting antimycobacterial activity (with MIC values of 29 and 70 μM respectively). The limonoids are typically lipophilic compounds present in the fruits of Melia azeradach. They are known as cytotoxic compounds against different cancer cell lines, while their potential as antiviral and antibacterial was poorly investigated.
    CONCLUSIONS:
    Our studies show that they may serve as a good starting point for the development of novel drugs for the treatment of infections by Flaviviruses and Mycobacterium tuberculosis, for which there is a continued need.
    Chem Biodivers. 2014 Aug;11(8):1121-39.
    Cytotoxic and nitric oxide production-inhibitory activities of limonoids and other compounds from the leaves and bark of Melia azedarach.[Pubmed: 25146759 ]
    Nine limonoids, 1-9, one apocarotenoid, 11, one alkaloid, 12, and one steroid, 13, from the leaf extract; and one triterpenoid, 10, five steroids, 14-18, and two flavonoids, 19 and 20, from the bark extract of Melia azedarach L. (Chinaberry tree; Meliaceae) were isolated.
    METHODS AND RESULTS:
    Among these compounds, three compounds, 4-6, were new, and their structures were established as 3-deacetyl-28-oxosalannolactone, 3-deacetyl-28-oxosalanninolide, and 3-deacetyl-17-defurano-17,28-dioxosalannin, respectively, on the basis of extensive spectroscopic analyses and comparison with literature data. All of the isolated compounds were evaluated for their cytotoxic activities against leukemia (HL60), lung (A549), stomach (AZ521), and breast (SK-BR-3) cancer cell lines. 3-Deacetyl-4'-demethyl-28-oxosalannin (3) against HL60 and AZ521 cells, and Methyl kulonate (10) against HL60 cells exhibited potent cytotoxicities with IC50 values in the range of 2.8-5.8 μM. In addition, upon evaluation of compounds 1-13 against production of nitric oxide (NO) in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide (LPS), seven, i.e., trichilinin B (1), 4, ohchinin (7), 23-hydroxyohchininolide (8), 21-hydroxyisoohchininolide (9), 10, and methyl indole 3-carboxylate (12), inhibited production of NO with IC50 values in the range of 4.6-87.3 μM with no, or almost no, toxicity to the cells (IC50 93.2-100 μM).
    CONCLUSIONS:
    Western blot analysis revealed that compound 7 reduced the expression levels of the inducible NO synthase (iNOS) and COX-2 proteins in a concentration-dependent manner. Furthermore, compounds 5, 6, 13, and 18-20 exhibited potent inhibitory effects (IC50 299-381 molar ratio/32 pmol TPA) against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cell line.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0631 mL 10.3154 mL 20.6309 mL 41.2618 mL 51.5772 mL
    5 mM 0.4126 mL 2.0631 mL 4.1262 mL 8.2524 mL 10.3154 mL
    10 mM 0.2063 mL 1.0315 mL 2.0631 mL 4.1262 mL 5.1577 mL
    50 mM 0.0413 mL 0.2063 mL 0.4126 mL 0.8252 mL 1.0315 mL
    100 mM 0.0206 mL 0.1032 mL 0.2063 mL 0.4126 mL 0.5158 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    茯苓酸G; Poricoic acid G CFN95056 415724-84-4 C30H46O5 = 486.7 5mg QQ客服:215959384
    大戟二烯醇; Euphol CFN89516 514-47-6 C30H50O = 426.71 10mg QQ客服:3257982914
    羊毛甾醇; Lanosterol CFN92368 79-63-0 C30H50O = 426.7 5mg QQ客服:1148253675
    丁酰鲸鱼醇; Butyrospermol CFN92376 472-28-6 C30H50O = 426.7 5mg QQ客服:2932563308
    苦楝酮; Kulinone CFN92977 21688-61-9 C30H48O2 = 440.70 5mg QQ客服:1413575084
    Aphagranin A ; Aphagranin A CFN96579 1318173-53-3 C33H54O6 = 546.79 5mg QQ客服:1148253675
    金钱松呋喃酸; Pseudolarifuroic acid CFN91924 130825-79-5 C30H42O4 = 466.65 5mg QQ客服:1148253675
    3-氧代甘遂-7,24-二烯-21-酸; 3-Oxotirucalla-7,24-dien-21-oic acid CFN97609 82464-35-5 C30H46O3 = 454.69 5mg QQ客服:215959384
    苦楝萜酸甲酯; Methyl kulonate CFN92975 22611-37-6 C31H48O4 = 484.71 5mg QQ客服:215959384
    帕克醇; Parkeol CFN92825 514-45-4 C30H50O = 426.7 5mg QQ客服:2159513211

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