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  • Aphagranin A

    Aphagranin A

    Aphagranin A
    产品编号 CFN96579
    CAS编号 1318173-53-3
    分子式 = 分子量 C33H54O6 = 546.79
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The stem barks of Aphanamixis grandifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Aphagranin A CFN96579 1318173-53-3 1mg QQ客服:215959384
    Aphagranin A CFN96579 1318173-53-3 5mg QQ客服:215959384
    Aphagranin A CFN96579 1318173-53-3 10mg QQ客服:215959384
    Aphagranin A CFN96579 1318173-53-3 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • MTT Agrifood Research Finland (Finland)
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  • Complutense University of Madrid (Spain)
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  • Michigan State University (USA)
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  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Sci.2014, 20(3):182-190
  • Anticancer Res.2014, 34(7):3505-9
  • Ind Crops Prod.2015, 67:185-191
  • BMC Complement Altern Med.2016, 16:213
  • University of Limpopo2016, 1777
  • Chemistry of Plant Materials.2016, 33-46
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • The Japan Society for Analytical Chemistry2017, 613-617
  • Sci Rep.2017, 7:467-479
  • Int J Mol Sci.2018, 19(9):E2825
  • Phytomedicine.2018, 47:48-57
  • Front Pharmacol.2018, 9:756
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Int J Biol Macromol.2019, 126:653-661
  • Food Engineering Progress2019, 23(3)209-216
  • Molecules.2019, 24(16):E2985
  • Molecules.2019, 24(2):E343
  • Molecules.2019, 24(23):E4303
  • Molecules.2019, 24(7):E1290
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Aquaculture2019, 510:392-399
  • Oxid Med Cell Longev2020, 12
  • J Pharmaceut Biomed2020, 182:113110
  • ...
  • 生物活性
    Description: Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.
    In vitro:
    Tetrahedron Letters, 2012, 53(14):1705-9.
    A pair of tirucallane C27-triterpenoid cyclopentenone epimers from the stem barks of Aphanamixis grandifolia[Reference: WebLink]

    METHODS AND RESULTS:
    Two novel tirucallane C27-triterpenoid epimers, aphagranins A (1) and B (2), featuring an unprecedented enolized cyclopentenone presented in the side-chain at C-17, were isolated from the stem barks of Aphanamixis grandifolia. Extensive spectroscopic analyses helped the establishment of the structures of the two isolates, whose absolute configurations were determined using density functional theory (DFT) calculations of optical rotation, and electronic circular dichroism (ECD).
    CONCLUSIONS:
    Remarkable discrepancies in the inhibitory activities against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823) were found for the two epimers: with IC50 less than 10 μM, Aphagranin A exhibited much stronger antiproliferative activity than aphagranin B, showing no such activities with IC50 over 20 μM.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8289 mL 9.1443 mL 18.2886 mL 36.5771 mL 45.7214 mL
    5 mM 0.3658 mL 1.8289 mL 3.6577 mL 7.3154 mL 9.1443 mL
    10 mM 0.1829 mL 0.9144 mL 1.8289 mL 3.6577 mL 4.5721 mL
    50 mM 0.0366 mL 0.1829 mL 0.3658 mL 0.7315 mL 0.9144 mL
    100 mM 0.0183 mL 0.0914 mL 0.1829 mL 0.3658 mL 0.4572 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    茯苓酸B; Poricoic acid B CFN95050 137551-39-4 C30H44O5 = 484.7 10mg QQ客服:2932563308
    茯苓酸G; Poricoic acid G CFN95056 415724-84-4 C30H46O5 = 486.7 5mg QQ客服:2159513211
    大戟二烯醇; Euphol CFN89516 514-47-6 C30H50O = 426.71 10mg QQ客服:3257982914
    羊毛甾醇; Lanosterol CFN92368 79-63-0 C30H50O = 426.7 5mg QQ客服:1413575084
    丁酰鲸鱼醇; Butyrospermol CFN92376 472-28-6 C30H50O = 426.7 5mg QQ客服:2159513211
    苦楝酮; Kulinone CFN92977 21688-61-9 C30H48O2 = 440.70 5mg QQ客服:1413575084
    Aphagranin A ; Aphagranin A CFN96579 1318173-53-3 C33H54O6 = 546.79 5mg QQ客服:1148253675
    金钱松呋喃酸; Pseudolarifuroic acid CFN91924 130825-79-5 C30H42O4 = 466.65 5mg QQ客服:2159513211
    3-氧代甘遂-7,24-二烯-21-酸; 3-Oxotirucalla-7,24-dien-21-oic acid CFN97609 82464-35-5 C30H46O3 = 454.69 5mg QQ客服:3257982914
    苦楝萜酸甲酯; Methyl kulonate CFN92975 22611-37-6 C31H48O4 = 484.71 5mg QQ客服:215959384

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