黄决明素

Chrysoobtusin

	产品编号	CFN91661
	CAS编号	70588-06-6
	分子式 = 分子量	C₁₉H₁₈O₇ = 358.34
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Anthraquinones
	植物来源	The seeds of Senna surattensis
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产品名称	产品编号	CAS编号	包装	QQ客服
黄决明素	CFN91661	70588-06-6	1mg	QQ客服：2056216494
黄决明素	CFN91661	70588-06-6	5mg	QQ客服：2056216494
黄决明素	CFN91661	70588-06-6	10mg	QQ客服：2056216494
黄决明素	CFN91661	70588-06-6	20mg	QQ客服：2056216494

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Description:

Chrysoobtusin is an anthraquinone derivative isolated from Semen Cassiae. Semen Cassiae has long been used to protect liver, brighten eyes, and relieve constipation.

In vitro:

Planta Med . 1997 Feb;63(1):11-14.

In vitro antimutagenic effects of anthraquinone aglycones and naphthopyrone glycosides from Cassia tora[Pubmed: 9063089]

The antimutagenic activity of a methanol extract of Cassia tora seeds against aflatoxin B1(AFB1) was demonstrated with the Salmonella typhimurium assay. The numbers of revertants per plate decreased significantly when this extract was added to the assay system using Salmonella typhimurium TA100 and/or TA98. The MeOH extract was then sequentially partitioned with CH2Cl2, n-BuOH and H2O. The CH2Cl2 and n-BuOH fractions possessed antimutagenic activity but the H2O fraction was inactive. Neither the MeOH extract nor its fractions were capable of inhibiting the direct-acting mutagen N-methyl-N'-nitro-N-nitrosoguanidine suggesting that these fractions may prevent the metabolic activation of AFB1 or scavenge the electrophilic intermediate capable of inducing mutations. Column chromatography using silica gel yielded pure chrysophanol, chryso-obtusin, and aurantio-obtusin from the CH2Cl2 fraction and cassiaside and rubro-fusarin gentiobioside from the n-BuOH fraction. Each of these compounds demonstrated significant antimutagenic activity.

J Microbiol Biotechnol . 2011 Oct;21(10):1043-1048.

Isolation and identification of antitumor promoters from the seeds of Cassia tora[Pubmed: 22031028]

A methanol extract of Cassia tora seeds was successively partitioned with diethyl ether, chloroform, ethyl acetate, and water, and the antitumor-promoting activity of the solvent fractions was determined by inhibition of Epstein- Barr virus early antigen (EBV-EA) activation induced by teleocidin B-4 in Raji cells. The diethyl ether (68.7%) and chloroform (91.2%) fractions and the hydrolysate (94.3%) of the ethyl acetate fraction had strong inhibitory activities. The chloroform and ethyl acetate fractions were chromatographed on silica gel and further purified by HPLC. Three active compounds, obtusifolin-2-glucoside (75.0%), chryso-obtusin-6-glucoside (56.8%), and norrubrofusarin- 6-glucoside (39.4%), were obtained from the ethyl acetate fraction, and two active compounds, questin (97.9%) and chryso-obtusin (53.8%), were isolated from the chloroform fraction.

In vivo:

J Sep Sci . 2019 Jul;42(14):2341-2350.

Nine components pharmacokinetic study of rat plasma after oral administration raw and prepared Semen Cassiae in normal and acute liver injury rats[Pubmed: 31037812]

In China, Semen Cassiae has long been used to protect liver, brighten eyes, and relieve constipation. Prepared Semen Cassiae is produced from raw Semen Cassiae by processing, the two forms of Semen Cassiae have different clinical applications. Pathological state is an important factor affecting the efficacy of drugs, the pharmacokinetic behavior of drugs could be significantly changed when people or animal were under different pathological state. To clarify the effect of processing mechanism and pathological state for pharmacokinetic behavior, the pharmacokinetics of nine components of raw and prepared Semen Cassiae under normal and acute liver injury rats were examined. The results showed that the bimodal phenomenon appeared on the plasma concentration-time profiles of obtusin, emodin, chrysophanol, aloe emodin and rhein. The Tmax of aurantio-obtusin, obtusin, chrysoobtusin, emodin, chrysophanol, aloe emodin, physcion in normal groups administrated prepared Semen Cassiae were shorter than those administrated raw Semen Cassiae. For the AUC0-t , aurantio-obtusin, obtusin, chrysoobtusin, chrysophanol, aloe emodin and physcione in model groups administrated prepared Semen Cassiae were significantly higher than other groups, unlike above components, rhein had poor absorption in model groups. The study would be useful for further studies on pharmacokinetics and clinical application of raw and prepared Semen Cassiae.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
芦荟大黄素; Aloeemodin	CFN98749	481-72-1	C₁₅H₁₀O₅ = 270.2	20mg	QQ客服：2159513211
羟基大黄素; Citreorosein	CFN98750	481-73-2	C₁₅H₁₀O₆ = 286.2	5mg	QQ客服：2159513211
2-羟基-1,5-二甲氧基-6-(甲氧基甲基)-9,10- 蒽二酮; 1,5,15-Tri-O-methylmorindol	CFN97518	942609-65-6	C₁₈H₁₆O₆ = 328.3	5mg	QQ客服：3257982914
橙黄决明素; Aurantio-obtusin	CFN99732	67979-25-3	C₁₇H₁₄O₇ = 330.29	20mg	QQ客服：215959384
决明素; Obtusin	CFN93032	70588-05-5	C₁₈H₁₆O₇ = 344.31	5mg	QQ客服：2056216494
黄决明素; Chrysoobtusin	CFN91661	70588-06-6	C₁₉H₁₈O₇ = 358.34	5mg	QQ客服：2056216494
1,3,6,8-四羟基-2-(1-羟基己基)-蒽醌 ; Averantin	CFN96721	5803-62-3	C₂₀H₂₀O₇ = 372.37	5mg	QQ客服：2159513211
大黄素; Emodin	CFN98834	518-82-1	C₁₅H₁₀O₅ = 270.2	20mg	QQ客服：2159513211
1-O-Methylnataloe-emodin; 1-O-Methylnataloe-emodin	CFN96731	103392-51-4	C₁₆H₁₂O₅ = 284.26	5mg	QQ客服：3257982914
大黄素甲醚; Physcion	CFN98848	521-61-9	C₁₆H₁₂O₅ = 284.3	20mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7906 mL	13.9532 mL	27.9065 mL	55.8129 mL	69.7661 mL
5 mM	0.5581 mL	2.7906 mL	5.5813 mL	11.1626 mL	13.9532 mL
10 mM	0.2791 mL	1.3953 mL	2.7906 mL	5.5813 mL	6.9766 mL
50 mM	0.0558 mL	0.2791 mL	0.5581 mL	1.1163 mL	1.3953 mL
100 mM	0.0279 mL	0.1395 mL	0.2791 mL	0.5581 mL	0.6977 mL

黄决明素

Chrysoobtusin

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