Info: Read More
  • 中药标准品生产商,产品定制服务
  • 大黄素甲醚

    Physcion

    大黄素甲醚
    产品编号 CFN98848
    CAS编号 521-61-9
    分子式 = 分子量 C16H12O5 = 284.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Anthraquinones
    植物来源 The roots and rhizomes of Rheum palmatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大黄素甲醚 CFN98848 521-61-9 10mg QQ客服:3257982914
    大黄素甲醚 CFN98848 521-61-9 20mg QQ客服:3257982914
    大黄素甲醚 CFN98848 521-61-9 50mg QQ客服:3257982914
    大黄素甲醚 CFN98848 521-61-9 100mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Eastern Finland (Finland)
  • Calcutta University (India)
  • Helmholtz Zentrum München (Germany)
  • University of Toulouse (France)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Celltrion Chemical Research Institute (Korea)
  • The University of Newcastle (Australia)
  • China Medical University (Taiwan)
  • Heidelberg University (Germany)
  • Lund University (Sweden)
  • Nanjing University of Chinese Medicine (China)
  • Imperial College London (United Kingdom)
  • Colorado State University (USA)
  • University of Mysore (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • American Association for Anatomy2020, doi: 10.1002.
  • JEJU National University2022, 10478.
  • J Nat Prod.2018, 81(4):966-975
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • J of Food Quality2020, 8851285.
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • Int. J. Mol. Sci.2022, 23(14),7699;
  • Current Traditional Medicine, 2021, 7:326-335(10).
  • Oncol Rep.2016, 35(3):1356-64
  • Exp Mol Med.2020, 52(4):629-642.
  • Journal of Functional Foods2022, 99: 105331.
  • Nutrients.2022, 14(23):4997.
  • Histol Histopathol.2022, 18518.
  • Curr Issues Mol Biol.2022, 44(5):2300-2308.
  • Front Plant Sci.2022, 13: 905275.
  • Heliyon2020, 6(6):e04337.
  • Antioxidants (Basel).2020, 9(4):326.
  • Int J Mol Med.2020, 45(5):1514-1524.
  • Preprints2017, 2017120176
  • BMC Complement Altern Med.2018, 18(1):303
  • ...
  • 生物活性
    Description: Physcion shows cytotoxic effect on human cervical carcinoma HeLa cells and its apoptosis induction in HeLa cells was investigated by the expressions of p53, p21, Bax, Bcl-2, caspase-9, and caspase-3 proteins. Physcion controls powdery mildew mainly through changing the expression of defence-related genes, and especially enhancing expression of leaf-specific thionin in barley leaves.
    Targets: Bcl-2/Bax | Caspase | p53 | ROS | CDK | c-Myc | p21
    In vitro:
    Microbiol Res. 2014 Apr;169(4):255-61.
    Physcion from marine-derived fungus Microsporum sp. induces apoptosis in human cervical carcinoma HeLa cells.[Pubmed: 24071573]
    Recently, the relationship between apoptosis and cancer has been emphasized and the induction of apoptosis is recognized as one of the key mechanisms of anti-cancer agents. Marine-derived fungi are valuable sources of structurally diverse bioactive anticancer agents.
    METHODS AND RESULTS:
    In the present study, a marine-derived fungus, Microsporum sp. was cultured and an anthraquinone derivative, physcion (11.8 mg) was isolated from the culture broth extract (1710 mg). Physcion has shown cytotoxic effect on human cervical carcinoma HeLa cells and its apoptosis induction in HeLa cells was investigated by the expressions of p53, p21, Bax, Bcl-2, caspase-9, and caspase-3 proteins. The Western blot analysis has revealed that physcion could significantly induce cell apoptosis through down-regulating of Bcl-2 expression, up-regulating of Bax expression, and activating the caspase-3 pathway. Furthermore, physcion induced the formation of reactive oxygen species (ROS) in HeLa cells.
    CONCLUSIONS:
    Collectively, these results suggest that physcion could be a potential candidate in the field of anticancer drug discovery against human cervical cancer.
    Pest Manag Sci. 2010 Jul;66(7):718-24.
    Physcion, a natural anthraquinone derivative, enhances the gene expression of leaf-specific thionin of barley against Blumeria graminis.[Pubmed: 20205209 ]
    Physcion is a key active ingredient of the ethanol extract from roots of Chinese rhubarb (Rheum officinale Baill.) that has been commercialised in China for controlling powdery mildews. The biological mechanism of action of Physcion against the barley powdery mildew pathogen was studied using bioassay and microarray methods.
    METHODS AND RESULTS:
    Bioassay indicated that Physcion did not directly affect conidial germination of Blumeria graminis Speer f. sp. hordei Marchal, but significantly inhibited conidial germination in vivo. Challenge inoculation indicated that Physcion induced localised resistance rather than systemic resistance against powdery mildew. Gene expression profiling of Physcion-treated barley leaves detected four upregulated and five downregulated genes (ratio >or= 2.0 and P-value < 0.05) by using an Affymetrix Barley GeneChip. The five upregulated probe sequences blasted to the same barley leaf-specific thionin gene, with significant changes varying from 4.26 to 19.91-fold. All downregulated genes were defence-related, linked to peroxidase, oxalate oxidase, bsi1 protein and a pathogenesis-related protein. These changes varied from - 2.34 to - 2.96. Quantitative real-time PCR data confirmed that Physcion enhanced the gene expression of leaf-specific thionin of barley.
    CONCLUSIONS:
    Results indicated that Physcion controls powdery mildew mainly through changing the expression of defence-related genes, and especially enhancing expression of leaf-specific thionin in barley leaves.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5174 mL 17.5871 mL 35.1741 mL 70.3482 mL 87.9353 mL
    5 mM 0.7035 mL 3.5174 mL 7.0348 mL 14.0696 mL 17.5871 mL
    10 mM 0.3517 mL 1.7587 mL 3.5174 mL 7.0348 mL 8.7935 mL
    50 mM 0.0703 mL 0.3517 mL 0.7035 mL 1.407 mL 1.7587 mL
    100 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.7035 mL 0.8794 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    大黄素甲醚; Physcion CFN98848 521-61-9 C16H12O5 = 284.3 20mg QQ客服:2056216494
    迷人醇; Fallacinol CFN91577 569-05-1 C16H12O6 = 300.3 5mg QQ客服:2159513211
    1,6-二羟基-8-甲氧基-3-甲基蒽-9,10-二酮; Questin CFN89155 3774-64-9 C16H12O5 = 284.26 5mg QQ客服:2056216494
    Questinol; Questinol CFN89152 35688-09-6 C16H12O6 = 300.26 5mg QQ客服:2159513211
    呫吨灵; 1,4,8-三羟基-6-甲基-3-甲氧基-9,10-蒽醌; Xanthorin CFN99826 17526-15-7 C16H12O6 = 300.3 5mg QQ客服:1457312923
    决明蒽醌; 美决明子素; Obtusifolin CFN90394 477-85-0 C16H12O5 = 284.27 20mg QQ客服:215959384
    6-羟基茜草素; 6-Hydroxyrubiadin CFN97444 87686-86-0 C15H10O5 = 270.2 5mg QQ客服:2159513211
    乳癖蒽醌; 2-甲基-3,6-二羟基-1-甲氧基-9,10-蒽醌; Rubianthraquinone CFN96569 644967-44-2 C16H12O5 = 284.26 5mg QQ客服:1413575084
    3-羟基巴戟醌; 3-hydroxymorindone CFN80104 80368-74-7 C15H10O6 = 286.24 10mg QQ客服:2159513211
    芦荟大黄素; Aloeemodin CFN98749 481-72-1 C15H10O5 = 270.2 20mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产