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  • 漆黄素; 紫铆素

    Butin

    漆黄素; 紫铆素
    产品编号 CFN97736
    CAS编号 492-14-8
    分子式 = 分子量 C15H12O5 = 272.25
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The seeds of Cassia tora
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    漆黄素; 紫铆素 CFN97736 492-14-8 1mg QQ客服:215959384
    漆黄素; 紫铆素 CFN97736 492-14-8 5mg QQ客服:215959384
    漆黄素; 紫铆素 CFN97736 492-14-8 10mg QQ客服:215959384
    漆黄素; 紫铆素 CFN97736 492-14-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas Airlangga (Indonesia)
  • Almansora University (Egypt)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Universidade Católica Portuguesa (Portugal)
  • University of Maryland School of Medicine (USA)
  • University of Vienna (Austria)
  • Helmholtz Zentrum München (Germany)
  • University of the Basque Country (Spain)
  • Aarhus University (Denmark)
  • Wageningen University (Netherlands)
  • The Institute of Cancer Research (United Kingdom)
  • Colorado State University (USA)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Weizmann Institute of Science (Israel)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2015, 12(5):7789-95
  • Sci Rep.2015, 5:13194
  • J Agric Food Chem.2015, 63(44):9869-78
  • Molecules.2016, 21(6)
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • J Chromatogr A.2017, 1518:46-58
  • Food Chem.2017, 228:301-314
  • Nat Prod Communications2018, 10.1177
  • Phytochemistry2018, 15:83-92
  • Molecules.2018, 23(7):E1659
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • Sci Adv.2018, 4(10)
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Sci Rep.2018, 8(1)
  • Planta Med.2018, 84(6-07):465-474
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Journal of Ginseng Research2019, 10.1016
  • Postharvest Biol Tec2019, 149:18-26
  • BMC Microbiol.2019, 19(1):78
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Phytomedicine.2019, 59:152785
  • J Mater Chem B.2019, 7(39):5896-5919
  • ...
  • 生物活性
    Description: Butin has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by activating Nrf2-mediated Mn SOD induction via the PI3K/Akt signaling pathway.Butin against H2O2-induced apoptosis were exerted via blockade of membrane potential depolarization, inhibition of the JNK pathway and mitochondria-involved caspase-dependent apoptotic pathway, enhancing the expression of phosphorylated Akt (active form of Akt), a regulator of OGG1.
    Targets: PI3K | Akt | Nrf2 | ROS | SOD | Calcium Channel | JNK | P450 (e.g. CYP17) | Bcl-2/Bax | Caspase | MAPK
    In vitro:
    J Cell Biochem. 2012 Jun;113(6):1987-97.
    The cytoprotective effect of butin against oxidative stress is mediated by the up-regulation of manganese superoxide dismutase expression through a PI3K/Akt/Nrf2-dependent pathway.[Pubmed: 22253095]
    Butin (7,3',4'-trihydroxydihydroflavone), a flavonoid with antioxidant activity, was recently reported to protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction. The objective of the present study was to elucidate the mechanism by which Butin protects mitochondria.
    METHODS AND RESULTS:
    The antioxidant function of manganese superoxide dismutase (Mn SOD) is important in preventing oxidative stress. While exposure to H2O2 reduced the expression of Mn SOD in Chinese hamster lung fibroblast (V79-4), the addition of Butin restored Mn SOD expression at both the mRNA and protein levels, resulting in increased Mn SOD activity. The transcription factor NF-E2-related factor 2 (Nrf2) regulates Mn SOD gene expression by binding to the antioxidant responsive element (ARE). Butin enhanced the nuclear translocation and ARE-binding activity of Nrf2, which was decreased by H2O2. The siRNA-mediated knockdown of Nrf2 attenuated Butin-induced Mn SOD expression and activity. Further, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB, Akt) contributed to the ARE-driven Mn SOD expression. Butin activated PI3K/Akt and exposure to either LY294002 (a PI3K inhibitor), Akt inhibitor IV (an Akt-specific inhibitor), or Akt siRNA suppressed the Butin-induced activation of Nrf2, resulting in decreased Mn SOD expression and activity. Finally, the cytoprotective effect of Butin against H2O2-induced cell damage was suppressed by the siRNA-mediated knockdown of Mn SOD.
    CONCLUSIONS:
    These studies demonstrate that Butin attenuates oxidative stress by activating Nrf2-mediated Mn SOD induction via the PI3K/Akt signaling pathway.
    Food Chem Toxicol. 2010 Mar;48(3):922-7.
    Butin reduces oxidative stress-induced mitochondrial dysfunction via scavenging of reactive oxygen species.[Pubmed: 20060874]
    This study investigated the cytoprotective effect of butin, a flavonoid, on hydrogen peroxide (H(2)O(2))-induced mitochondrial dysfunction.
    METHODS AND RESULTS:
    Electron spin resonance (ESR) spectrometry revealed butin's significant scavenging effects on superoxide radicals and hydroxyl radicals. When H(2)O(2) was used to induce an increase in mitochondrial reactive oxygen species (ROS) in Chinese hamster lung fibroblast (V79-4) cells, butin treatment decreased high level of ROS. Butin also attenuated intracellular Ca(2+) levels that have been induced by H(2)O(2). Furthermore, butin recovered ATP levels and succinate dehydrogenase activity that had been decreased by H(2)O(2) treatment.
    CONCLUSIONS:
    We conclude these results suggest butin decreased mitochondrial ROS accumulation, balanced intracellular Ca(2+) levels, and improved mitochondrial energy production, thus recovering mitochondrial function.
    Chem Biol Interact. 2009 Oct 30;181(3):338-42.
    Butin decreases oxidative stress-induced 8-hydroxy-2'-deoxyguanosine levels via activation of oxoguanine glycosylase 1.[Pubmed: 19631197]
    In response to oxidative DNA base damage, oxoguanine glycosylase 1 (OGG1), in a base-excision repair (BER) pathway in mammals, plays a vital role in the repair of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is a reliable marker of reactive oxygen species (ROS)-induced DNA base modification and contributes to the pathologic process of cancer.Recently, we have shown that butin (7,3',4'-trihydroxydihydroflavone) protects cells against hydrogen peroxide (H2O2)-induced damage of cellular components including DNA.
    METHODS AND RESULTS:
    In the present study, we examined the possible protective effect of butin on oxidative stress-induced DNA base modification, especially 8-OHdG. Hydrogen peroxide significantly increased the level of 8-OHdG, which was detected by 8-OHdG ELISA and confocal microscopy, but butin decreased this level. Suppression of 8-OHdG formation by butin was related to the enhanced mRNA and protein expression of OGG1, which was detected by RT-PCR and Western blot analysis. Butin also increased the transcriptional activity of OGG1, which was suppressed by H2O2 treatment; this transcriptional activity was detected by OGG1 promoter luciferase assay. Butin enhanced the expression of phosphorylated Akt (active form of Akt), a regulator of OGG1, which was decreased by H2O2 treatment.
    CONCLUSIONS:
    A PI3K-specific inhibitor, LY294002, abolished the phosphorylated Akt and OGG1 expressions induced by butin, suggesting that OGG1 induction by butin involves the PI3K/Akt pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6731 mL 18.3655 mL 36.7309 mL 73.4619 mL 91.8274 mL
    5 mM 0.7346 mL 3.6731 mL 7.3462 mL 14.6924 mL 18.3655 mL
    10 mM 0.3673 mL 1.8365 mL 3.6731 mL 7.3462 mL 9.1827 mL
    50 mM 0.0735 mL 0.3673 mL 0.7346 mL 1.4692 mL 1.8365 mL
    100 mM 0.0367 mL 0.1837 mL 0.3673 mL 0.7346 mL 0.9183 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异奥卡宁; Isookanin CFN90850 1036-49-3 C15H12O6 = 288.3 10mg QQ客服:2932563308
    黄诺马苷; Flavanomarein CFN91006 577-38-8 C21H22O11 = 450.4 5mg QQ客服:2159513211
    黄苏木素; Plathymenin CFN96496 492-12-6 C15H12O6 = 288.25 5mg QQ客服:1413575084
    圣草酚; Eriodictyol CFN99719 552-58-9 C15H12O6 = 288.25 20mg QQ客服:2932563308
    7-O-甲基圣草酚; 7-O-Methyleriodictyol CFN98833 51857-11-5 C16H14O6 = 302.3 5mg QQ客服:215959384
    高圣草素; Homoeriodictyol CFN96489 446-71-9 C16H14O6 = 302.28 5mg QQ客服:1413575084
    槲寄生新甙III; Viscumneoside III CFN89421 118985-27-6 C27H32O15 = 596.53 10mg QQ客服:2932563308
    圣草酚 7,3'-二甲醚; Eriodictyol 7,3'-dimethyl ether CFN89533 54352-60-2 C17H16O6 = 316.30 5mg QQ客服:1148253675
    橙皮素; Hesperetin CFN98842 520-33-2 C16H14O6 = 302.3 20mg QQ客服:1413575084
    橙皮素-7-甲醚; Hesperetin-7-methyl ether CFN90876 N/A C17H16O6 = 316.3 10mg QQ客服:1148253675

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