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  • 高圣草素

    Homoeriodictyol

    高圣草素
    产品编号 CFN96489
    CAS编号 446-71-9
    分子式 = 分子量 C16H14O6 = 302.28
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Taxillus sutchuenensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
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    高圣草素 CFN96489 446-71-9 1mg QQ客服:215959384
    高圣草素 CFN96489 446-71-9 5mg QQ客服:215959384
    高圣草素 CFN96489 446-71-9 10mg QQ客服:215959384
    高圣草素 CFN96489 446-71-9 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2019, 21(1):E265
  • Front Pharmacol.2017, 8:673
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  • Trop J Nat Prod Res.2019, 3(1):6-9
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  • Nutrients2022, 14(3),695.
  • Molecules.2019, 24(9):E1719
  • Cancers (Basel).2021, 13(9):2223.
  • Functional Ecology2020, doi: 10.1111.
  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Biocell2023, 47(8):1793-1802
  • Biomed Pharmacother.2022, 145:112410.
  • Nutrients.2018, 10(7)
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • ...
  • 生物活性
    Description: Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.
    Targets: GLUT | 5-HT Receptor | Sodium Channel
    In vitro:
    PLoS One. 2017 Feb 13;12(2):e0171580.
    The flavanone homoeriodictyol increases SGLT-1-mediated glucose uptake but decreases serotonin release in differentiated Caco-2 cells.[Pubmed: 28192456 ]
    Flavanoids and related polyphenols, among them hesperitin, have been shown to modulate cellular glucose transport by targeting SGLT-1 and GLUT-2 transport proteins.
    METHODS AND RESULTS:
    We aimed to investigate whether homoeriodictyol, which is structurally related to hesperitin, affects glucose uptake in differentiated Caco-2 cells as a model for the intestinal barrier. The results revealed that, in contrast to other polyphenols, the flavanon homoeriodictyol promotes glucose uptake by 29.0 ± 3.83% at a concentration of 100 μM. The glucose uptake stimulating effect was sensitive to phloridzin, but not to phloretin, indicating an involvement of the sodium-coupled glucose transporter SGLT-1, but not of sodium-independent glucose transporters (GLUT). In addition, in contrast to the increased extracellular serotonin levels by stimulation with 500 mM D-(+)-glucose, treatment with 100 μM homoeriodictyol decreased serotonin release by -48.8 ± 7.57% in Caco-2 cells via a phloridzin-sensitive signaling pathway. Extracellular serotonin levels were also reduced by -57.1 ± 5.43% after application of 0.01 μM homoeriodictyol to human neural SH-SY5Y cells.
    CONCLUSIONS:
    In conclusion, we demonstrate that homoeriodictyol affects both the glucose metabolism and the serotonin system in Caco-2 cells via a SGLT-1-meditated pathway. Furthermore, the results presented here support the usage of Caco-2 cells as a model for peripheral serotonin release. Further investigations may address the value of homoeriodictyol in the treatment of anorexia and malnutrition through the targeting of SGLT-1.
    In vivo:
    Mol Nutr Food Res. 2017 Aug 21.
    Appetite-Inducing Effects of Homoeriodictyol: Two Randomized, Cross-Over Interventions.[Pubmed: 28834253 ]
    Anorexia of aging, characterized by a decrease in appetite and/or food intake, is a major risk factor of under-nutrition and adverse health outcomes in elderly people. Recent in vitro evidence suggests homoeriodictyol (HED), a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake.
    METHODS AND RESULTS:
    In two cross-over intervention trials, 30 mg NaHED, either solely (n = 10, Study I) or in combination with a 75 g glucose load (n = 17, study II) were administered to healthy adult subjects. Ratings of hunger were assessed at fasting and either 30 min (Study I) or 120 min (Study II) post intervention. Ad libitum energy intake from a standardized breakfast and plasma changes in hunger-/satiety-associated hormones PYY, GLP-1, ghrelin and serotonin were determined after blood drawings. Effects were more pronounced when NaHED was administered in combination with 75 g glucose since ad libitum energy (+ 9.52 ± 4.60%) and protein (+ 7.08 ± 7.97%) intake as well as plasma ΔAUC ghrelin values increased in study II solely, whereas plasma serotonin concentrations decreased after both interventions.
    CONCLUSIONS:
    NaHED demonstrated appetizing effects in healthy adults when administered with a glucose load. Long-term intervention studies are warranted to verify these effects in compromised subjects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3082 mL 16.541 mL 33.0819 mL 66.1638 mL 82.7048 mL
    5 mM 0.6616 mL 3.3082 mL 6.6164 mL 13.2328 mL 16.541 mL
    10 mM 0.3308 mL 1.6541 mL 3.3082 mL 6.6164 mL 8.2705 mL
    50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.3233 mL 1.6541 mL
    100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.6616 mL 0.827 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-O-甲基圣草酚; 7-O-Methyleriodictyol CFN98833 51857-11-5 C16H14O6 = 302.3 5mg QQ客服:2159513211
    高圣草素; Homoeriodictyol CFN96489 446-71-9 C16H14O6 = 302.28 5mg QQ客服:1413575084
    槲寄生新甙III; Viscumneoside III CFN89421 118985-27-6 C27H32O15 = 596.53 10mg QQ客服:2159513211
    圣草酚 7,3'-二甲醚; Eriodictyol 7,3'-dimethyl ether CFN89533 54352-60-2 C17H16O6 = 316.30 5mg QQ客服:2056216494
    橙皮素; Hesperetin CFN98842 520-33-2 C16H14O6 = 302.3 20mg QQ客服:3257982914
    橙皮素-7-甲醚; Hesperetin-7-methyl ether CFN90876 N/A C17H16O6 = 316.3 10mg QQ客服:1413575084
    圣草酚 7,3',4'-三甲醚; 7,3',4'-Tri-O-methyleriodictyol CFN89491 70987-96-1 C18H18O6 = 330.33 5mg QQ客服:2056216494
    (2S)-5,7,3'4'-四甲氧基二氢黄酮; (2S)-5,7,3',4'-tetramethoxyflavanone CFN95406 74628-43-6 C19H20O6 = 344.4 10mg QQ客服:2159513211
    5,6,7,3',4'-五甲氧基二氢黄酮; 5,6,7,3',4'-Pentamethoxyflavanone CFN95394 104193-93-3 C20H22O7 = 374.4 5mg QQ客服:1413575084
    异奥卡宁; Isookanin CFN90850 1036-49-3 C15H12O6 = 288.3 20mg QQ客服:2056216494

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