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  • 宝藿苷I

    Baohuoside I

    宝藿苷I
    产品编号 CFN98525
    CAS编号 113558-15-9
    分子式 = 分子量 C27H30O10 = 514.52
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Epimedium brevicornu Maxim
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    宝藿苷I CFN98525 113558-15-9 10mg QQ客服:2159513211
    宝藿苷I CFN98525 113558-15-9 20mg QQ客服:2159513211
    宝藿苷I CFN98525 113558-15-9 50mg QQ客服:2159513211
    宝藿苷I CFN98525 113558-15-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University of Canterbury (New Zealand)
  • Florida A&M University (USA)
  • University of Mysore (India)
  • Florida International University (USA)
  • University of British Columbia (Canada)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Korea Food Research Institute(KFRI) (Korea)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of East Anglia (United Kingdom)
  • Tokyo Woman's Christian University (Japan)
  • National Chung Hsing University (Taiwan)
  • Medical University of Gdansk (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11(43):562-6
  • Exp Parasitol.2015, 153:160-4
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • HortTechnology2016, 26(6):816-819
  • Nutrients.2017, 10(1)
  • PLoS One.2017, 12(3):e0173585
  • Plant Methods.2017, 13:108
  • Mol Pharm.2017, 14(9):3164-3177
  • J Ethnopharmacol.2017, 196:75-83
  • Molecules.2017, 22(12)
  • Food Chem.2017, 221:1135-1144
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • Fitoterapia.2018, 124:92-102
  • Phytother Res.2018, 32(5):923-932
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • J of Physics Conference Series2019, 1349(1)
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Molecules.2019, 24(7):E1290
  • Phytother Res.2019, 33(5):1490-1500
  • Phytomedicine.2019, 57:95-104
  • Process Biochemistry2019, 87:213-220
  • Br J Pharmacol.2020, 10.1111
  • ...
  • 生物活性
    Description: Baohuoside I is a novel immunosuppressive molecule, exhibits antimetastatic, anti-osteoporosis, anti-inflammatory and anti-cancer activities. Baohuoside I can inhibit the proliferation of Eca-109 cells, this effect associats with down-regulation expression of β-catenin,Cyclin D1,Survivin,and their proteins,which affects on the Wnt/β-catenin signaling pathway.
    Targets: CXCR | Wnt/β-catenin | ROS | Bcl-2/Bax | Caspase | JNK | p38MAPK
    In vitro:
    Chinese Traditional & Herbal Drugs, 2011, 42(1):124-6.
    Effect of baohuoside-I on Wnt/β-catenin signaling pathway of human esophageal carcinoma cell Eca-109.[Reference: WebLink]
    To study the effect of baohuoside-I extracted from Periplocae Cortex on proliferation and Wnt/β-catenin signaling pathway of human esophageal carcinoma cell Eca-109.
    METHODS AND RESULTS:
    The expressions of β-catenin, Cyclin D1, and Survivin protein in Eca-109 cells were measured with flow cytometry (FCM). The expressions of β-catenin, Cyclin D1, and Survivin mRNA were detected by RT-PCR. After treatment with 25 and 50 μg/mL of baohuoside I for 48 h, the expression levels of β-catenin, Cyclin D1, Survivin mRNA, and protein were decreased significantly (P<0.01), but with 12.5 μg/ML of baohuoside I the expression level was not decreased significantly compared with the control group.
    CONCLUSIONS:
    : baohuoside I from Periplocae Cortex could inhibit the proliferation of Eca-109 cells. This effect associais with down-regulation expression of β-catenin, Cyclin D1, Survivin, and their proteins, which affects on the Wnt/β-catenin signaling pathway.
    Chem Biol Interact. 2012 Jul 30;199(1):9-17.
    Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer.[Pubmed: 22687635]
    Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai. Although Baohuoside I exhibits anti-inflammatory and anti-cancer activities, its molecular targets/pathways in human lung cancer cells are poorly understood. Therefore, in the present study, we investigated the usefulness of Baohuoside I as a potential apoptosis-inducing cytotoxic agent using human adenocarcinoma alveolar basal epithelial A549 cells as in vitro model.
    METHODS AND RESULTS:
    The apoptosis induced by Baohuoside I in A549 cells was confirmed by annexin V/propidium iodide double staining, cell cycle analysis and dUTP nick end labeling. Further research revealed that Baohuoside I accelerated apoptosis through the mitochondrial apoptotic pathway, involving the increment of BAX/Bcl-2 ratio, dissipation of mitochondrial membrane potential, transposition of cytochrome c, caspase 3 and caspase 9 activation, degradation of poly (ADP-ribose) polymerase and the over-production of reactive oxygen species (ROS). A pan-caspase inhibitor, Z-VAD-FMK, only partially prevented apoptosis induced by Baohuoside I, while NAC, a scavenger of ROS, diminished its effect more potently. In addition, the apoptotic effect of Baohuoside I was dependent on the activation of ROS downstream effectors, JNK and p38(MAPK), which could be almost abrogated by using inhibitors SB203580 (an inhibitor of p38(MAPK)) and SP600125 (an inhibitor of JNK).
    CONCLUSIONS:
    These findings suggested that Baohuoside I might exert its cytotoxic effect via the ROS/MAPK pathway.
    Transplantation. 2004 Sep 27;78(6):831-8.
    Baohuoside-1, a novel immunosuppressive molecule, inhibits lymphocyte activation in vitro and in vivo.[Pubmed: 15385801]
    We evaluated the in vitro and in vivo immunosuppressive effects of Baohuoside I (B1), a novel flavonoid isolated from Epimedium davidii.
    METHODS AND RESULTS:
    Proliferation assay was used to determine the antiproliferative properties on T-cell and B-cell proliferation. Flow cytometry analysis was applied to detect changes of phenotypes on activated cells. B1 inhibits the lymphocyte proliferation activated by polyclonal mitogens and mixed lymphocyte reaction with a 50% inhibitory concentration of low micromolar concentration. Also, B1 suppressed T-cell activation in T cell receptor/CD3-mediated signaling pathways in a dose- and time-dependent manner. The suppression of B1 was not simply a result of a toxic effect and was recovered by withdrawing the drug. B1 down-regulated the expression of some phenotype molecules. In Ca(2+)-independent or -dependent antigen stimulation, although B1 had different inhibitive patterns on CD69 expression stimulated by phorbol 12-myristate 13-acetate (PMA) or Ca2+ ionophore, it inhibited T-cell proliferation induced by CD3/CD28 or PMA/ionomycin and partially blocked that induced by PMA/CD28. Interestingly, an additive inhibition between B1 and tacrolimus (FK506) was found in the CD69 expression stimulated by PMA/CD28 and PMA/ionomycin. Similarly, this immunosuppression by combination therapy was observed in a heart transplantation model in vivo and might act through an immunosuppressive mechanism different from FK506.
    CONCLUSIONS:
    B1, whose mechanism of action is not similar to that of FK506, has selectively immunosuppressive effects on T-cell and B-cell activation in vitro and effectively prevents rat heart allograft rejection in vivo.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9436 mL 9.7178 mL 19.4356 mL 38.8712 mL 48.589 mL
    5 mM 0.3887 mL 1.9436 mL 3.8871 mL 7.7742 mL 9.7178 mL
    10 mM 0.1944 mL 0.9718 mL 1.9436 mL 3.8871 mL 4.8589 mL
    50 mM 0.0389 mL 0.1944 mL 0.3887 mL 0.7774 mL 0.9718 mL
    100 mM 0.0194 mL 0.0972 mL 0.1944 mL 0.3887 mL 0.4859 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    大花淫羊藿苷F; Ikarisoside F CFN90138 113558-14-8 C31H36O14 = 632.62 5mg QQ客服:3257982914
    淫羊藿属苷A; Epimedoside A CFN90762 39012-04-9 C32H38O15 = 662.7 10mg QQ客服:2159513211
    宝藿苷V; Baohuoside V CFN90763 118544-18-6 C38H48O19 = 808.8 10mg QQ客服:2159513211
    宝藿苷I; Baohuoside I CFN98525 113558-15-9 C27H30O10 = 514.52 20mg QQ客服:2159513211
    箭藿苷B; Sagittatoside B CFN90211 118525-36-3 C32H38O14 = 646.64 5mg QQ客服:2159513211
    2''-O-鼠李糖基淫羊藿次苷II; 2''-O-Rhamnosylicariside II CFN92551 135293-13-9 C33H40O14 = 660.7 10mg QQ客服:2932563308
    Sutchuenmedin A; Sutchuenmedin A CFN96542 1197194-31-2 C33H38O14 = 658.65 5mg QQ客服:215959384
    箭藿苷A; Sagittatoside A CFN90139 118525-35-2 C33H40O15 = 676.67 5mg QQ客服:2159513211
    箭藿苷C; Sagittatoside C CFN92077 118525-37-4 C35H42O16 = 718.7 5mg QQ客服:215959384
    异箭藿苷A; Iso-sagittatoside A CFN91155 503456-08-4 C33H40O15 = 676.7 5mg QQ客服:215959384

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