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  • 白术内酯III; 苍术内酯III

    Atractylenolide III

    白术内酯III; 苍术内酯III
    产品编号 CFN99946
    CAS编号 73030-71-4
    分子式 = 分子量 C15H20O3 = 248.32
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Atractylodes macrocephala Koidz.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    白术内酯III; 苍术内酯III CFN99946 73030-71-4 10mg QQ客服:215959384
    白术内酯III; 苍术内酯III CFN99946 73030-71-4 20mg QQ客服:215959384
    白术内酯III; 苍术内酯III CFN99946 73030-71-4 50mg QQ客服:215959384
    白术内酯III; 苍术内酯III CFN99946 73030-71-4 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Charles Sturt University (Denmark)
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  • Chiang Mai University (Thailand)
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  • Donald Danforth Plant Science Center (USA)
  • Charles University in Prague (Czech Republic)
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  • Universite Libre de Bruxelles (Belgium)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytochem Anal.2013, 24(5):493-503
  • Auburn University2015, 1-58
  • J Med Food.2016, 19(12):1155-1165
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Sci Rep. 2017, 17332(7)
  • J Ethnopharmacol.2017, 206:73-77
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Phytother Res.2018, 32(5):923-932
  • Oncology Letters2018, 4690-4696
  • J Agric Food Chem.2018, 66(1):351-358
  • Saf Health Work.2019, 10(2):196-204
  • Clin Transl Oncol.2019, 10.1007
  • Biomed Pharmacother.2019, 111:262-269
  • Biomed Pharmacother.2019, 116:108987
  • J of Essential Oil Research2019, 1677272
  • J Adv Res.2019, 17:85-94
  • Molecules.2019, 24(16):E3003
  • Toxicol In Vitro.2019, 59:161-178
  • Phytomedicine.2019, 65:153089
  • J Nat Prod.2019, 82(4):1002-1008
  • Process Biochemistry2019, 85:106-115
  • Food Funct.2020, 10.1039
  • ...
  • 生物活性
    Description: Atractylenolide III, a potential house dust mite control agent, has neuroprotection, gastroprotective, anti-cancer, and anti-inflammatory activities, it also may control immunological reactions by regulating the cellular functions of IL-6 in mast cells. It inhibited nuclear factor-κB and mitogen-activated protein kinase pathways in mouse macrophages, and inhibited Lipopolysaccharide-induced TNF- α and NO production in macrophages.
    Targets: ERK | p38MAPK | NF-kB | JNK | TNF-α | PGE | NO | IL Receptor | COX | Caspase | NOS
    In vitro:
    Immunopharmacol Immunotoxicol. 2016;38(2):98-102.
    Anti-inflammatory activity of atractylenolide III through inhibition of nuclear factor-κB and mitogen-activated protein kinase pathways in mouse macrophages.[Pubmed: 26667579 ]

    METHODS AND RESULTS:
    To elucidate the anti-inflammatory mechanisms involved, we investigated the effects of Atractylenolide III (ATL-III) on cytokine expression, extracellular signal-regulated kinases 1 and 2 (ERK1/2), p38 mitogen-activated protein kinase (p38), C-Jun-N-terminal protein kinase1/2 (JNK1/2) and nuclear factor-κB (NF-κB) pathways in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages. Macrophages were incubated with various concentrations (0, 25, 50, 100 μM) of ATL-III and/or LPS (1 μg/mL) for 24 h. The production of nitric oxide (NO) was determined by the Greiss reagent. The production of tumor necrosis factor alpha (TNF-α), prostaglandin E2 (PGE2) and interleukin 6 (IL-6) was determined by enzyme-linked immunosorbent assay (ELISA). Furthermore, macrophages were treated with ATL-III (0, 25, 100 μM) for 1 h and then stimulated by LPS. NF-κB, p38, JNK1/2 and ERK1/2 were determined by western blotting. We found ATL-III showed no inhibitory effect on cell proliferation at concentrations ranging from 1 μM to 100 μM. In addition, ATL-III decreased the release of NO, TNF-α, PGE2 and IL-6 in a dose-dependent manner and showed statistically significant at concentrations of 50 μM and 100 μM as well as cyclooxygenase-2 (COX-2) expression. Furthermore, ATL-III suppressed the transcriptional activity of NF-κB. ATL-III also inhibited the activation of ERK1/2, p38 and JNK1/2 in LPS-treated macrophages and showed statistically significant at concentrations of 25 μM and 100 μM.
    CONCLUSIONS:
    These data suggest that ATL-III shows an anti-inflammatory effect by suppressing the release of NO, PGE2, TNF-α and IL-6 related to the NF-κB- and MAPK-signaling pathways.
    Neurochem Res. 2014 Sep;39(9):1753-8.
    Neuroprotection of atractylenolide III from Atractylodis macrocephalae against glutamate-induced neuronal apoptosis via inhibiting caspase signaling pathway.[Pubmed: 24958167]

    CONCLUSIONS:
    Glutamate-induced excitotoxicity appears to play a crucial role in neurological disorders. Neuroprotection against glutamate-induced excitotoxicity has been proposed as a therapeutic strategy for preventing and/or treating these excitotoxicity-mediated diseases. In the present study, atractylenolide III, which exhibited significantly neuroprotective effect against glutamate-induced neuronal apoptosis, was isolated from Atractylodes macrocephala by means of bioactivity-guided fractionation. The inhibitory effect of atractylenolide III on glutamate-induced neuronal apoptosis was in a concentration-dependent manner. The anti-apoptotic property of atractylenolide III might be mediated, in part, via inhibiting caspase signaling pathway.
    CONCLUSIONS:
    Atractylenolide III may have therapeutic potential in excitotoxicity-mediated neurological diseases.
    J Agric Food Chem. 2007 Jul 25;55(15):6027-31.
    Toxicity of atractylon and atractylenolide III Identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus.[Pubmed: 17595110]

    CONCLUSIONS:
    The acaricidal activity of materials derived from rhizome of Atractylodes ovata (Atractylodes macrocephala) toward adult Dermatophagoides farinae and Dermatophagoides pteronyssinus was examined using fabric-circle residual contact and vapor-phase toxicity bioassays. Results were compared with those of the currently used acaricides: benzyl benzoate, dibutyl phthalate, and N,N-diethyl-m-toluamide (Deet). The active principles of A. ovata rhizome were identified as the sesquiterpenoids, atractylenolide III (1) and atractylon (2), by spectroscopic analysis. In fabric-circle residual contact bioassays with adult D. farinae, atractylenolide III (LD50, 103.3 mg/m2) and atractylon (136.2 mg/m2) were five and four times more toxic than Deet and 1.7- and 1.3-fold more active than dibutyl phthalate, respectively, based on 24 h LD50 values. These compounds were less toxic than benzyl benzoate (LD50, 45.8 mg/m2). Against adult D. pteronyssinus, atractylenolide III (LD50, 73.8 mg/m2) and atractylon (72.1 mg/m2) were eight times more active than Deet and 2.5-fold more toxic than dibutyl phthalate. These compounds were slightly less effective than benzyl benzoate (LD50, 46.0 mg/m2). In vapor-phase toxicity tests with both mite species, atractylenolide III and atractylon were effective in closed but not in open containers.
    CONCLUSIONS:
    These results indicate that the effect of these sesquiterpenoids was largely a result of action in the vapor phase. Naturally occurring atractylenolide III and atractylon merit further study as potential house dust mite control agents or leads because of their great activity as a fumigant.
    In vivo:
    J Pharm Pharmacol. 2010 Mar;62(3):381-8
    Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo.[Pubmed: 20487223 ]
    The rhizome of Atractylodes ovata De Candolle is popularly used in traditional Chinese medicine to treat gastrointestinal diseases. However, the major gastroprotective compounds of A. ovata have not been identified. This study reports on the principal gastro- protective component of A. ovata.
    METHODS AND RESULTS:
    Five sesquiterpenoids (atractylon, atractylenolides I, II, III and biatractylolide) were isolated from the extracts of A. ovata rhizome via silica gel column chromatography. The gastroprotective effects of these five sesquiterpenoids were measured in in-vitro ethanol-induced primary culture rat gastric mucosal (PRGM) cell damage and in-vivo ethanol-induced acute rat gastric ulcer models. Atractylon, atractylenolide I and biatractylolide were strongly toxic in PRGM cells, whilst atractylenolides II and III were not. Atractylenolide II did not show cytoprotective effects, but oral administration of atractylenolide III dose-dependently prevented ethanol-induced PRGM cell death and cell membrane damage. The EC50 values were 0.27 and 0.34 mm, respectively. In the in-vivo assay, atractylenolide III 10 mg/kg significantly reduced 70% ethanol-induced Wistar rat gastric ulcer. Atractylenolide III could inhibit matrix metalloproteinase (MMP)-2 and MMP-9 expression through upregulation of tissue inhibitors of metalloproteinase from the gastric ulcerated tissues.
    CONCLUSIONS:
    Atractylenolide III was the major gastroprotective component of A. ovata in ethanol-induced acute gastric ulcer. It is suggested that the gastroprotective mechanism of atractylenolide III was via inhibition of the MMP-2 and MMP-9 pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0271 mL 20.1353 mL 40.2706 mL 80.5412 mL 100.6765 mL
    5 mM 0.8054 mL 4.0271 mL 8.0541 mL 16.1082 mL 20.1353 mL
    10 mM 0.4027 mL 2.0135 mL 4.0271 mL 8.0541 mL 10.0677 mL
    50 mM 0.0805 mL 0.4027 mL 0.8054 mL 1.6108 mL 2.0135 mL
    100 mM 0.0403 mL 0.2014 mL 0.4027 mL 0.8054 mL 1.0068 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-O-Methacryloyltrilobolide; 6-O-Methacryloyltrilobolide CFN89319 950685-51-5 C23H30O9 = 450.48 5mg QQ客服:2932563308
    Wedeliatrilolactone A; Wedeliatrilolactone A CFN96438 156993-29-2 C23H32O9 = 452.49 5mg QQ客服:215959384
    4,8-二羟基桉叶-7(11)-烯-12,8-内酯; 4,8-Dihydroxyeudesm-7(11)-en-12,8-olide CFN99348 1231208-53-9 C15H22O4 = 266.3 5mg QQ客服:3257982914
    白术内酯I; 苍术内酯I; Atractylenolide I CFN99944 73069-13-3 C15H18O2 = 230.30 20mg QQ客服:1413575084
    白术内酯II; 苍术内酯II; Atractylenolide II CFN99945 73069-14-4 C15H20O2 = 232.32 20mg QQ客服:2932563308
    白术内酯III; 苍术内酯III; Atractylenolide III CFN99946 73030-71-4 C15H20O3 = 248.32 20mg QQ客服:2159513211
    双白术内酯; Biatractylolide CFN95205 182426-37-5 C30H38O4 = 462.6 10mg QQ客服:215959384
    8beta-Methoxyatractylenolide I; 8beta-Methoxyatractylenolide I CFN89314 193694-24-5 C16H22O3 = 262.34 5mg QQ客服:1413575084
    芹烷二烯酮; Selina-4(15),7(11)-dien-8-one CFN95078 54707-47-0 C15H22O = 218.3 10mg QQ客服:1413575084
    Chlorantholide A; Chlorantholide A CFN97968 1372558-33-2 C15H16O3 = 244.3 5mg QQ客服:2159513211

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