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    白术内酯II; 苍术内酯II

    Atractylenolide II

    白术内酯II; 苍术内酯II
    产品编号 CFN99945
    CAS编号 73069-14-4
    分子式 = 分子量 C15H20O2 = 232.32
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Atractylodes macrocephala Koidz.
    产品名称 产品编号 CAS编号 包装 QQ客服
    白术内酯II; 苍术内酯II CFN99945 73069-14-4 10mg QQ客服:2932563308
    白术内酯II; 苍术内酯II CFN99945 73069-14-4 20mg QQ客服:2932563308
    白术内酯II; 苍术内酯II CFN99945 73069-14-4 50mg QQ客服:2932563308
    白术内酯II; 苍术内酯II CFN99945 73069-14-4 100mg QQ客服:2932563308
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    doi: 10.1021/acsnano.7b08969.

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    doi: 10.1038/nplants.2016.205.

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    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
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  • 生物活性
    Description: Atractylenolide II has antiinflammatory activity, it can inhibit platelets activities and thrombus formation. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation ,ERK and Akt inactivation, p53 dependent, it also has antimelanoma effect by inhibiting STAT3 signalling.
    Targets: STAT | Src | CDK | Akt | ERK | Bcl-2/Bax | p38MAPK | Caspase | p53 | p21
    In vitro:
    J. Am. Coll. Cardiol., 2015, 66(16):C44-C44.
    GW26-e1245 Atractylenolide II and Atractylenolide III Inhibit Platelets Activities and Thrombus Formation[Reference: WebLink]
    Atractylenolide II and Atractylenolide III Inhibit Platelets Activities and Thrombus Formation.
    Biomed Chromatogr. 2007 Mar;21(3):299-303.
    Determination of atractylenolide II in rat plasma by reversed-phase high-performance liquid chromatography.[Pubmed: 17236249]

    A method for quantitative determination of Atractylenolide II in rat plasma using reversed-phase high-performance liquid chromatography (RP-HPLC) coupled with UV spectrometry was established. From a variety of compounds and solvents tested, Atractylenolide III was selected as the internal standard (IS) and ethyl acetate was found to be the best solvent for extracting Atractylenolide II from plasma samples. RP-HPLC analysis of the extracts was performed on an analytical column (DIKMA ODS, 150 x 4.6 mm; i.d., 5 microm) equipped with a security guard pre-column system. There was good linearity over the range 0.05-5.0 microg/mL (r > 0.99). The recoveries were more than 90.0% in plasma, and the intra- and inter-day coefficients of variation were less than 10.0% in all cases. The limit of detection (LOD) was 0.025 microg/mL and the lower limit of quantification (LLOQ) was 0.05 microg/mL.
    The RP-HPLC method was applied to quantitate Atractylenolide II in rat plasma within 24 h in a pharmacokinetics study where experimental rats received a single dose of Atractylenolide II (60 mg/kg).
    Phytotherapy Research, 2007, 21(4):347-353.
    Antiinflammatory Principles of Atractylodes Rhizomes.[Reference: WebLink]
    The crude drug"jutsu"prepared from Atractylodes rhizomes has been used for antiinflammatory purposes in Oriental medicine.
    In fact, a preparation from A. japonica was found to show significant inhibition of the increased vascular permeability induced by acetic acid. Fractionation of the extract, monitoring by bioassay, resulted in the isolation of two active principles, (+)-eudesma-4 (14), 7 (11)-dien-8-one (VI) and atractylenolide I (VII).
    The structurally related principles Atractylenolide II and III (VIII and IX) also had the tendency to show antiinflammatory activity.
    In vivo:
    Exp Dermatol. 2014 Nov;23(11):855-7.
    Inhibition of STAT3 signalling contributes to the antimelanoma action of atractylenolide II.[Pubmed: 25073716]
    Our previous studies showed that atractylenolide II (AT-II) has antimelanoma effects in B16 melanoma cells.
    In this study, we investigated the involvement of STAT3 signalling in the antimelanoma action of AT-II. Daily administration of AT-II (12.5, 25 mg/kg, i.g.) for 14 days significantly inhibited tumor growth in a B16 xenograft mouse model and inhibited the activation/phosphorylation of STAT3 and Src in the xenografts. In B16 and A375 cells, AT-II (20, 40 μm) treatment for 48 h dose-dependently reduced protein expression levels of phospho-STAT3, phospho-Src, as well as STAT3-regulated Mcl-1 and Bcl-xL. Overexpression of a constitutively active variant of STAT3, STAT3C in A375 cells diminished the antiproliferative and apoptotic effects of AT-II. These data suggest that inhibition of STAT3 signalling contributes to the antimelanoma action of AT-II.
    Our findings shed new light on the mechanism of action underlying the antimelanoma effects of AT-II and provide further pharmacological basis for developing AT-II as a novel melanoma chemopreventive/chemotherapeutic agent.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.3044 mL 21.522 mL 43.0441 mL 86.0882 mL 107.6102 mL
    5 mM 0.8609 mL 4.3044 mL 8.6088 mL 17.2176 mL 21.522 mL
    10 mM 0.4304 mL 2.1522 mL 4.3044 mL 8.6088 mL 10.761 mL
    50 mM 0.0861 mL 0.4304 mL 0.8609 mL 1.7218 mL 2.1522 mL
    100 mM 0.043 mL 0.2152 mL 0.4304 mL 0.8609 mL 1.0761 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    白术内酯II; 苍术内酯II; Atractylenolide II CFN99945 73069-14-4 C15H20O2 = 232.32 20mg QQ客服:3257982914
    白术内酯III; 苍术内酯III; Atractylenolide III CFN99946 73030-71-4 C15H20O3 = 248.32 20mg QQ客服:2932563308
    双白术内酯; Biatractylolide CFN95205 182426-37-5 C30H38O4 = 462.6 10mg QQ客服:1413575084
    8beta-Methoxyatractylenolide I; 8beta-Methoxyatractylenolide I CFN89314 193694-24-5 C16H22O3 = 262.34 5mg QQ客服:2056216494
    芹烷二烯酮; Selina-4(15),7(11)-dien-8-one CFN95078 54707-47-0 C15H22O = 218.3 10mg QQ客服:3257982914
    Chlorantholide A; Chlorantholide A CFN97968 1372558-33-2 C15H16O3 = 244.3 5mg QQ客服:1457312923
    Chlorantholide B; Chlorantholide B CFN97967 1372558-34-3 C15H18O3 = 246.3 5mg QQ客服:1413575084
    Chlorantholide C; Chlorantholide C CFN97970 1372558-35-4 C15H18O3 = 246.3 5mg QQ客服:2159513211
    Chlorantholide D; Chlorantholide D CFN97956 1253106-58-9 C15H18O4 = 262.3 5mg QQ客服:1457312923
    Chlorantholide E; Chlorantholide E CFN97969 1372558-36-5 C15H18O5 = 278.3 5mg QQ客服:2159513211





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