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    产品编号 CFN92233
    CAS编号 550-43-6
    分子式 = 分子量 C14H22N2O = 234.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Lupinus angustifolius
    产品名称 产品编号 CAS编号 包装 QQ客服
    Angustifoline CFN92233 550-43-6 1mg QQ客服:1413575084
    Angustifoline CFN92233 550-43-6 5mg QQ客服:1413575084
    Angustifoline CFN92233 550-43-6 10mg QQ客服:1413575084
    Angustifoline CFN92233 550-43-6 20mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
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  • Complutense University of Madrid (Spain)
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  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
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  • 生物活性
    Description: Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stimulating G2/M cell cycle arrest.
    Targets: Antifection
    In vitro:
    Annals of the Entomological Society of America, 1984, 77(4):398-400.
    Lupine Alkaloids as Larval Feeding Deterrents for Spruce Budworm, Choristoneura fumiferana (Lepidoptera: Tortricidae).[Reference: WebLink]
    Twelve lupine alkaloids, eight from Lupinus polyphyllus (Lindl), were tested in feeding bioassays against sixth instar spruce budworm, Choristoneura fumiferana (Clemens).
    Feeding deterrence was found in the alkaloid fraction of L. polyphyllus extracts. Eight lupine alkaloids shown to be present in the extract were tested at the rate of 25 μg per feeding disc. Of these compounds, 13-trans-cinnamoyloxylupanine and 13- tigloyloxylupanine were highly deterrent, whereas lupanine, sparteine, 13-hydroxylupanine, tetrahydrorhombifoline, angustifoline, and 17-oxolupanine, were not. Four alkaloids not present in L. polyphyllus, lupinine, epilupinine, α-isolupanine, and lupinyl-trans-cinnamate, were not active at 25 μg per feeding disc.
    Clearly, there is wide variability in the response of spruce budworm larvae, which are not adapted to feeding on alkaloids, to various alkaloids within the same structural class. If this variability in response is general among herbivores, perhaps the presence of an alkaloid is not significant with regard to defense, whereas diversity in structure of alkaloids may deter generalist grazers.
    Journal of Plant Physiology, 1988, 133(2):240-242.
    The Effect of Lupin Alkaloids and Ethanol Extracts from Seeds of Lupinus angustifolius on Selected Bacterial Strains.[Reference: WebLink]

    The following pure alkaloids were isolated from lupin seeds (L. angustifolius var. Mirela): lupanine, 13-OH-lupanine, angustifoline and a 48 % ethanol extract. They and the commercial sparteine were tested for bacteriostatic effects against pathogenic bacteria, namely, Gram-positive (Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 6633) and Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853); a strain of Gram-positive Bacillus thuringiensis HD-4 with sporeforming rods, isolated from soil, was also tested.The established bacteriostatic agents, e.g. antibiotics, are active at a concentration 3 to 4 orders of magnitude lower than the tested lupin alkaloids.
    Therefore a bacteriostatic effect is possible in plants under physiological conditions, but a pharmaceutical application of these products as bacteriostatic agents is rather unlikely. The presented data support the allelopathic function of alkaloids.
    Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2019.
    Angustifoline inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stimulating G2/M cell cycle arrest.[Reference: WebLink]
    The prime objective of the present study was to investigate the anticancer properties of angustifoline against COLO-205 human colon cancer cells. Its effects on cell autophagy, apoptosis, cell invasion and cell migration, and cell cycle arrest were also evaluated in the current study.
    WST-1 assay was used to study cytotoxic effects of the compound on the cell viability. Effects on apoptosis and cell cycle arrest were evaluated by flow cytometry. In vitro wound healing assay and matrigel assay were carried out to study the effects of angustifoline on cell migration and cell invasion respectively. To confirm autophagy, we evaluated the expression of several autophagy-associated proteins using Western blot assay along with transmission electron microscopy (TEM).
    The findings indicated that angustifoline induced dose- and time-dependent cytotoxicity in COLO-205 human colon cancer cells along with inhibiting cancer cell colony formation. Angustifoline-treated cells exhibited cell shrinkage along with distortion of the normal cell morphology.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    硫酸金雀花碱; Sparteine sulfate pentahydrate CFN99777 299-39-8 C15H28N2O4S = 332.46 20mg QQ客服:1457312923
    金雀花碱; Cytisine CFN99513 485-35-8 C11H14N2O = 190.24 20mg QQ客服:2932563308
    N-甲基野靛碱; N-Methylcytisine CFN99776 486-86-2 C12H16N2O = 204.27 20mg QQ客服:1457312923
    黄华碱; Thermopsine CFN90461 486-90-8 C15H20N2O = 244.33 10mg QQ客服:1457312923
    安纳基林; Anagyrine CFN92067 486-89-5 C15H20N2O = 244.3 5mg QQ客服:2056216494
    赝靛叶碱; Baptifoline CFN91986 732-50-3 C15H20N2O2 = 260.33 5mg QQ客服:3257982914
    alpha-异羽扇豆鹼; alpha-Isolupanine CFN91985 486-87-3 C15H24N2O = 248.36 5mg QQ客服:3257982914
    羽扇豆鹼; Lupanine CFN98924 550-90-3 C15H24N2O = 248.4 5mg QQ客服:2056216494
    13-羟基羽扇豆鹼; 13-Hydroxylupanine CFN92232 15358-48-2 C15H24N2O2 = 264.4 5mg QQ客服:3257982914
    Angustifoline; Angustifoline CFN92233 550-43-6 C14H22N2O = 234.3 5mg QQ客服:2056216494





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