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    产品编号 CFN98924
    CAS编号 550-90-3
    分子式 = 分子量 C15H24N2O = 248.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Cytisus scoparius
    产品名称 产品编号 CAS编号 包装 QQ客服
    羽扇豆鹼 CFN98924 550-90-3 1mg QQ客服:1413575084
    羽扇豆鹼 CFN98924 550-90-3 5mg QQ客服:1413575084
    羽扇豆鹼 CFN98924 550-90-3 10mg QQ客服:1413575084
    羽扇豆鹼 CFN98924 550-90-3 20mg QQ客服:1413575084
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  • ...
  • 生物活性
    Description: Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lupanine improves glucose homeostasis by influencing KATP-channels of pancreatic beta cells.
    Targets: Calcium Channel | ATPase | Potassium Channel
    In vitro:
    Planta Med. 1987 Oct;53(5):465-9.
    Uptake of Lupanine by Alkaloid-Storing Epidermal Cells of Lupinus polyphyllus.[Pubmed: 17269069]

    Epidermis of steins and petioles of LUPINUS POLYPHYLLUS accumulates quinolizidine alkaloids at a concentration of about 30 mM. Since Lupanine is synthesized mainly in green mesophyll tissue and not in the epidermis, the alkaloids have to be transported into the epidermal cells. Uptake of [ (3)H]-Lupanine into isolated epidermis was 3 to 20 times higher in epidermal cells as compared to the corresponding mesophyll cells. Uptake of Lupanine is time dependent and proceeds against a concentration gradient. The uptake depends on temperature and can be characterized by an activation energy of 34 kJ/mol. The process shows multiphasic uptake kinetics and is reduced by SH-group inhibitors (NEM, PHMB) and inhibitors of the energy metabolism (cyanide, antimycine, DNP, CCCP).
    All these data provide first evidence that simple diffusion cannot be the mechanism for the uptake of Lupanine into epidermal cells. The uptake is probably catalyzed by transport proteins.
    In vivo:
    J Pharm Pharmacol. 1998 Aug;50(8):949-54.
    A comparative study of the effects of sparteine, lupanine and lupin extract on the central nervous system of the mouse.[Pubmed: 9751462]
    Lupin is toxic because of its alkaloid content, sparteine and lupanine in particular. Although the pharmacological properties of sparteine are well known those of lupanine have not been much studied.
    This paper reports procedures for extraction, purification and crystallization of lupanine, and methods for the preparation of an extract for injection of Lupinus mutabilis Sweet, and for the determination of the acute toxicity and maximum non-lethal dose (DL0) of lupanine, sparteine and lupin extract in the mouse. The three substances were tested on the central nervous system (CNS) for locomotor activity, for interaction with specific drugs used for treatment of the CNS (the stimulant drugs amphetamine and pentetrazol and the depressant drugs pentobarbital and chlorpromazine) and for analgesic activity.
    The results indicate that lupanine and lupin extract are less toxic than sparteine and that at the doses studied the three products have a weak sedative effect on the CNS.
    Molecules. 2015 Oct 20;20(10):19085-100.
    Lupanine Improves Glucose Homeostasis by Influencing KATP Channels and Insulin Gene Expression.[Pubmed: 26492234 ]
    The glucose-lowering effects of lupin seeds involve the combined action of several components. The present study investigates the influence of one of the main quinolizidine alkaloids, Lupanine, on pancreatic beta cells and in an animal model of type-2 diabetes mellitus.
    In vitro studies were performed with insulin-secreting INS-1E cells or islets of C57BL/6 mice. In the in vivo experiments, hyperglycemia was induced in rats by injecting streptozotocin (65 mg/kg body weight). In the presence of 15 mmol/L glucose, insulin secretion was significantly elevated by 0.5 mmol/L Lupanine, whereas the alkaloid did not stimulate insulin release with lower glucose concentrations. In islets treated with l-arginine, the potentiating effect of Lupanine already occurred at 8 mmol/L glucose. Lupanine increased the expression of the Ins-1 gene. The potentiating effect on secretion was correlated to membrane depolarization and an increase in the frequency of Ca(2 ) action potentials. Determination of the current through ATP-dependent K⁺ channels (KATP channels) revealed that Lupanine directly inhibited the channel. The effect was dose-dependent but, even with a high Lupanine concentration of 1 mmol/L or after a prolonged exposure time (12 h), the KATP channel block was incomplete. Oral administration of Lupanine did not induce hypoglycemia. By contrast, Lupanine improved glycemic control in response to an oral glucose tolerance test in streptozotocin-diabetic rats.
    In summary, Lupanine acts as a positive modulator of insulin release obviously without a risk for hypoglycemic episodes.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0258 mL 20.1288 mL 40.2576 mL 80.5153 mL 100.6441 mL
    5 mM 0.8052 mL 4.0258 mL 8.0515 mL 16.1031 mL 20.1288 mL
    10 mM 0.4026 mL 2.0129 mL 4.0258 mL 8.0515 mL 10.0644 mL
    50 mM 0.0805 mL 0.4026 mL 0.8052 mL 1.6103 mL 2.0129 mL
    100 mM 0.0403 mL 0.2013 mL 0.4026 mL 0.8052 mL 1.0064 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    安纳基林; Anagyrine CFN92067 486-89-5 C15H20N2O = 244.3 5mg QQ客服:3257982914
    赝靛叶碱; Baptifoline CFN91986 732-50-3 C15H20N2O2 = 260.33 5mg QQ客服:2159513211
    alpha-异羽扇豆鹼; alpha-Isolupanine CFN91985 486-87-3 C15H24N2O = 248.36 5mg QQ客服:3257982914
    羽扇豆鹼; Lupanine CFN98924 550-90-3 C15H24N2O = 248.4 5mg QQ客服:3257982914
    13-羟基羽扇豆鹼; 13-Hydroxylupanine CFN92232 15358-48-2 C15H24N2O2 = 264.4 5mg QQ客服:1148253675
    Angustifoline; Angustifoline CFN92233 550-43-6 C14H22N2O = 234.3 5mg QQ客服:1413575084
    菱叶野决明碱; Rhombifoline CFN91059 529-78-2 C15H20N2O = 244.34 10mg QQ客服:215959384
    硫酸金雀花碱; Sparteine sulfate pentahydrate CFN99777 299-39-8 C15H28N2O4S = 332.46 20mg QQ客服:1148253675
    金雀花碱; Cytisine CFN99513 485-35-8 C11H14N2O = 190.24 20mg QQ客服:1148253675
    N-甲基野靛碱; N-Methylcytisine CFN99776 486-86-2 C12H16N2O = 204.27 20mg QQ客服:1148253675





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