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  • 8-姜烯酚

    8-Shogaol

    8-姜烯酚
    产品编号 CFN92299
    CAS编号 36700-45-5
    分子式 = 分子量 C19H28O3 = 304.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Zingber officinale Rosc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    8-姜烯酚 CFN92299 36700-45-5 1mg QQ客服:3257982914
    8-姜烯酚 CFN92299 36700-45-5 5mg QQ客服:3257982914
    8-姜烯酚 CFN92299 36700-45-5 10mg QQ客服:3257982914
    8-姜烯酚 CFN92299 36700-45-5 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Copenhagen University (Denmark)
  • Universidad Industrial de Santander (Colombia)
  • University of Padjajaran (Indonesia)
  • Srinakharinwirot University (Thailand)
  • Wroclaw Medical University (Poland)
  • Semmelweis Unicersity (Hungary)
  • University of Bonn (Germany)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Vienna (Austria)
  • Universidade Católica Portuguesa (Portugal)
  • University of Hull (United Kingdom)
  • University of Amsterdam (Netherlands)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11:S585-91
  • J Med Food.2016, 19(12):1155-1165
  • J Ethnopharmacol.2016, 194:219-227
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • Semyung University2017, 149407
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Research on Crops.2017, 18(2)
  • International. J. of Food Properties 2017, 20:S131-S140
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Sci Rep.2017, 7(1):3249
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • PLoS One.2018, 13(3):e0193386
  • Life Sci.2018, 209:498-506
  • Molecules.2018, 23(3):E615
  • Food Chem.2018, 252:207-214
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Food and Fermentation Industries2018, 44(371)
  • Life Sci.2019, 216:259-270
  • Molecules.2019, 24(1):E159
  • Phytomedicine.2019, 59:152785
  • J Clin Med.2019, 8(10):E1664
  • J Cell Physiol.2020, 10.1002
  • Cell Metab.2020, S1550-4131(20)30002-4
  • ...
  • 生物活性
    Description: 8-Shogaol can induce apoptosis in a time- and concentration-dependent manner by reactive oxygen species production and depletion of glutathione in HL-60 cells.
    Targets: ROS
    In vivo:
    Mol Nutr Food Res. 2013 Mar;57(3):447-58.
    Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol.[Pubmed: 23322393]
    Shogaols, a series of major constituents in dried ginger with the most abundant being [6]-, [8]-, and [10]-shogaols, show much higher anticancer potencies than gingerols. Previously, we reported the mercapturic acid pathway as a major metabolic route for [6]-shogaol in mice. However, it is still unclear how the side chain length affects the metabolism of shogaols and how shogaols are metabolized in humans.
    METHODS AND RESULTS:
    We first investigate the metabolism of [10]-shogaol in mouse urine, and then investigate the biotransformation of shogaols in human urine. Our results show that eight major thiol-conjugated metabolites of [10]-shogaol were detected in mouse urine, while six major thiol-conjugated metabolites of [6]-shogaol, two thiol-conjugated metabolites of 8-Shogaol, and two thiol-conjugated metabolites of [10]-shogaol were detected in urine collected from human after drinking ginger tea, using LC/ESI-MS/MS. Our results clearly indicate the mercapturic acid pathway is a major metabolic route for [10]-shogaol in mice and for shogaols in human. Furthermore, we also investigated the regulation of glutathione (GSH) by [6]-shogaol in human colon cancer cells HCT-116. Our results show [6]-shogaol, after initially depleting glutathione levels, can subsequently restore and increase GSH levels over time.
    CONCLUSIONS:
    Shogaols are metabolized extensively in mouse and human to form thiol-conjugated metabolites and GSH might play an important role in the cancer-preventive activity of ginger.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2852 mL 16.4258 mL 32.8515 mL 65.703 mL 82.1288 mL
    5 mM 0.657 mL 3.2852 mL 6.5703 mL 13.1406 mL 16.4258 mL
    10 mM 0.3285 mL 1.6426 mL 3.2852 mL 6.5703 mL 8.2129 mL
    50 mM 0.0657 mL 0.3285 mL 0.657 mL 1.3141 mL 1.6426 mL
    100 mM 0.0329 mL 0.1643 mL 0.3285 mL 0.657 mL 0.8213 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二乙酰氧基-4-姜二醇; Diacetoxy-4-gingerdiol CFN92373 863780-88-5 C19H28O6 = 352.4 5mg QQ客服:2932563308
    甲基 二乙酰氧基-6-姜二醇; Methyl diacetoxy-6-gingerdiol CFN92301 863780-90-9 C22H34O6 = 394.5 5mg QQ客服:1148253675
    1-脱氢-6-姜酮; 1-Dehydro-6-gingerdione CFN92298 76060-35-0 C17H22O4 = 290.4 5mg QQ客服:2932563308
    6-姜烯酚; 6-Shogaol CFN99531 555-66-8 C17H24O3 = 276.37 20mg QQ客服:2159513211
    二乙酰氧基-6-姜二醇; Diacetoxy-6-gingerdiol CFN92375 143615-75-2 C21H32O6 = 380.5 5mg QQ客服:215959384
    非洲豆蔻醇; Paradol CFN91045 27113-22-0 C17H26O3 = 278.39 10mg QQ客服:215959384
    8-姜烯酚; 8-Shogaol CFN92299 36700-45-5 C19H28O3 = 304.4 5mg QQ客服:2932563308
    10-姜烯酚; 10-Shogaol CFN92300 36752-54-2 C21H32O3 = 332.5 10mg QQ客服:2932563308
    6-姜酚; 6-Gingerol CFN99931 23513-14-6 C17H26O4 = 294.4 20mg QQ客服:3257982914
    8-姜酚; 8-Gingerol CFN99131 23513-08-8 C19H30O4 = 322.44 20mg QQ客服:215959384

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