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  • 10-姜酚

    10-Gingerol

    10-姜酚
    产品编号 CFN99132
    CAS编号 23513-15-7
    分子式 = 分子量 C21H34O4 = 350.49
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Zingiber officinale Roscoe.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    10-姜酚 CFN99132 23513-15-7 10mg QQ客服:1413575084
    10-姜酚 CFN99132 23513-15-7 20mg QQ客服:1413575084
    10-姜酚 CFN99132 23513-15-7 50mg QQ客服:1413575084
    10-姜酚 CFN99132 23513-15-7 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Limpopo (South Africa)
  • Lund University (Sweden)
  • Medical University of Gdansk (Poland)
  • Universidade do Porto (Portugal)
  • Seoul National University (Korea)
  • Siksha O Anusandhan University (India)
  • Universidad de La Salle (Mexico)
  • University of Hull (United Kingdom)
  • S.N.D.T. Women's University (India)
  • National Cancer Institute (USA)
  • Srinakharinwirot University (Thailand)
  • Gyeongsang National University (Korea)
  • Universidade de Franca (Brazil)
  • University of Illinois at Chicago (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Sci.2014, 20(3):182-190
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • Onco Targets Ther.2017, 10:3467-3474
  • Plant Methods.2017, 13:108
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • J Hematol Oncol.2018, 11(1):112
  • Int J Mol Sci.2018, 19(9):E2681
  • Food Chem.2018, 262:78-85
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Sci Adv.2018, 4(10)
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Biorxiv2019, 10.1101
  • Biomed Pharmacother.2019, 116:108987
  • Molecules.2019, 24(11):E2044
  • Pak J Pharm Sci.2019, 32(6)
  • Environ Toxicol.2019, 34(12):1354-1362
  • Toxicol Res.2019, 35(4):371-387
  • Phytomedicine.2019, 55:229-237
  • Toxicol In Vitro.2019, 59:161-178
  • Pharmacol Rep.2019, 71(2):289-298
  • Biomed Chromatogr.2019, 8:e4774
  • Comput Biol Chem.2019, 83:107096
  • Appl. Sci.2020, 10,1304
  • ...
  • 生物活性
    Description: 10-Gingerol has anti-cancer, anti-neuroinflammatory, and anti-bacterial effects, it effectively inhibits the growth of the oral pathogens, and inhibits exogenous ghrelin deacylation.10-Gingerol induces [Ca2+]i rise by causing Ca2+ release from the endoplasmic reticulum and Ca2+ influx from non-L-type Ca2+ channels in SW480 cancer cells.10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK).
    Targets: JNK | p38MAPK | ERK | Calcium Channel | Bcl-2/Bax | NF-kB | IL Receptor | TNF-α | Akt
    In vitro:
    Food Chem. 2013 Dec 1;141(3):3183-91.
    Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol.[Pubmed: 23871076]
    Despite the anti-neuroinflammatory capacity of ginger, the corresponding active constituents are unclear.
    METHODS AND RESULTS:
    This study analyzed the composition of fresh ginger ethanolic extract by using LC-MS. Inhibitory activities of fresh ginger extract and seven gingerol-related compounds on the neuro-inflammation were also evaluated by using a lipopolysaccharide (LPS)-activated BV2 microglia culture model. Except for zingerone and 6-gingerol, other gingerols and shogaols at a concentration of 20 μM inhibited the production of nitric oxide, IL-1β, IL-6 and TNF-α as well as their mRNA levels in LPS-activated BV2 microglia. Blocking NF-κB activation was the underlying mechanism responsible for inhibiting the proinflammatory gene expression. Increasing the alkyl chain length enhanced the anti-neuroinflammatory capacity of gingerols yet, conversely, attenuated those of shogaols. 6-Gingerol was the most abundant compound in the fresh ginger extract, followed by 10-Gingerol. Furthermore, fresh ginger extract exhibited a significant anti-neuroinflammatory capacity, which was largely owing to 10-Gingerol, but not 6-gingerol.
    In vivo:
    Biochem Biophys Res Commun. 2011 Sep 2;412(3):506-11.
    10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation.[Pubmed: 21846463]
    Rikkunshito (RKT), a Japanese traditional medicine, has been shown to stimulate food intake in rats with cisplatin-induced anorexia; however, the underlying mechanisms remain unknown.
    METHODS AND RESULTS:
    In this study, we investigated whether RKT is involved in the degradation of peripheral ghrelin. RKT inhibited decreases in plasma ghrelin level and enhanced acyl- to desacyl-ghrelin (A/D) ratio in cisplatin-treated rats. Several components of RKT demonstrated inhibitory activity against ghrelin deacylating enzymes. In addition, 10-Gingerol, a component of RKT, inhibited exogenous ghrelin deacylation.
    CONCLUSIONS:
    Therefore, RKT may enhance plasma acyl-ghrelin level, at least in part, by inhibiting the circulating ghrelin degrading enzyme.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8531 mL 14.2657 mL 28.5315 mL 57.063 mL 71.3287 mL
    5 mM 0.5706 mL 2.8531 mL 5.7063 mL 11.4126 mL 14.2657 mL
    10 mM 0.2853 mL 1.4266 mL 2.8531 mL 5.7063 mL 7.1329 mL
    50 mM 0.0571 mL 0.2853 mL 0.5706 mL 1.1413 mL 1.4266 mL
    100 mM 0.0285 mL 0.1427 mL 0.2853 mL 0.5706 mL 0.7133 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甲基 二乙酰氧基-6-姜二醇; Methyl diacetoxy-6-gingerdiol CFN92301 863780-90-9 C22H34O6 = 394.5 5mg QQ客服:2159513211
    1-脱氢-6-姜酮; 1-Dehydro-6-gingerdione CFN92298 76060-35-0 C17H22O4 = 290.4 5mg QQ客服:215959384
    6-姜烯酚; 6-Shogaol CFN99531 555-66-8 C17H24O3 = 276.37 20mg QQ客服:215959384
    二乙酰氧基-6-姜二醇; Diacetoxy-6-gingerdiol CFN92375 143615-75-2 C21H32O6 = 380.5 5mg QQ客服:215959384
    非洲豆蔻醇; Paradol CFN91045 27113-22-0 C17H26O3 = 278.39 10mg QQ客服:1148253675
    8-姜烯酚; 8-Shogaol CFN92299 36700-45-5 C19H28O3 = 304.4 5mg QQ客服:1148253675
    10-姜烯酚; 10-Shogaol CFN92300 36752-54-2 C21H32O3 = 332.5 10mg QQ客服:1148253675
    6-姜酚; 6-Gingerol CFN99931 23513-14-6 C17H26O4 = 294.4 20mg QQ客服:3257982914
    8-姜酚; 8-Gingerol CFN99131 23513-08-8 C19H30O4 = 322.44 20mg QQ客服:3257982914
    10-姜酚; 10-Gingerol CFN99132 23513-15-7 C21H34O4 = 350.49 20mg QQ客服:215959384

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