Info: Read More
    		•
  • 中药标准品生产商，产品定制服务
    		•
  • 首页
  • 天然产物
  • 产品文献
  • 最新产品
  • 订购流程
  • 公司新闻
  • 公司简介
  • 联系我们
  • 首页
  • /
  • 天然产物（标准品）
  • /
  • 1-脱氢-10-姜酮

    • 1-脱氢-10-姜酮

    1-Dehydro-10-gingerdione

    1-脱氢-10-姜酮
    		产品编号 CFN92374
    CAS编号 136826-50-1
    分子式 = 分子量 C21H30O4 = 346.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Zingber officinale Rosc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1-脱氢-10-姜酮 CFN92374 136826-50-1 1mg QQ客服：3257982914
    1-脱氢-10-姜酮 CFN92374 136826-50-1 5mg QQ客服：3257982914
    1-脱氢-10-姜酮 CFN92374 136826-50-1 10mg QQ客服：3257982914
    1-脱氢-10-姜酮 CFN92374 136826-50-1 20mg QQ客服：3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

    2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。 但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常，这些可用于长达两周。 使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话：
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到：027-84254680

    • 提供订购信息
  • 为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号（CAS No.或产品名称）
  • 2. 发货地址
  • 3. 联系方法 (联系人，电话）
  • 4. 开票抬头 (如果需要发票的客户）
  • 5. 发票地址（发货地址与发票地址不同）
    • 发货时间
    1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Shanghai University of TCM (China)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Julius Kühn-Institut (Germany)
  • Texas A&M University (USA)
  • VIT University (India)
  • University of East Anglia (United Kingdom)
  • University of Queensland (Australia)
  • John Innes Centre (United Kingdom)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • China Medical University (Taiwan)
  • National Chung Hsing University (Taiwan)
  • Imperial College London (United Kingdom)
  • University of Vienna (Austria)
  • University of Ioannina (Greece)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant Pathology2022, 10.1111:ppa.13651.
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
  • Sci Rep.2017, 7:46299
  • Theranostics.2023, 13(9):3103-3116.
  • Appl. Sci.2022, 12(17), 8646.
  • Int J Mol Sci.2022, 23(24):16000.
  • Drug Dev Res.2020, doi: 10.1002
  • Evidence-based Compl.&Alternative Med.2023, 5417813
  • Chem Biol Interact.2022, 368:110248.
  • BMC Plant Biol.2021, 21(1):60.
  • Molecules.2018, 23(12):E3103
  • Molecules.2021, 26(23):7390.
  • Environ Toxicol.2019, 34(12):1354-1362
  • Molecules.2021, 26(9):2526.
  • J Nat Med.2021, doi: 10.1007.
  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • J Food Biochem.2021, 45(7):e13774.
  • Int J Mol Med.2016, 37(2):501-8
  • J Breast Cancer.2015, 18(2):112-118
  • Fitoterapia.2018, 124:92-102
  • Green Chemistry2021, ISSUE 2.
  • Process Biochemistry2019, 85:106-115
  • Appl. Sci. 2021, 11(17),7829
  • ...
    • 生物活性
    Description: 1-Dehydro-10-gingerdione has anti-inflammatory action, the molecular target is Myeloid differentiation protein; it involves in the suppression of NF-κB-regulated gene expression in LPS-activated macrophages, has therapeutic potential in NF-κB-associated inflammation and autoimmune disorders.
    Targets: NF-kB | TLR | IkB | TNF-α | NOS | COX | IL Receptor | AP-1 | IFN-γ | IKK
    In vitro:
    Br J Pharmacol. 2012 Sep;167(1):128-40.
    1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes.[Pubmed: 22489648]
    Pungent constituents of ginger (Zingiber officinale) have beneficial effects on inflammatory pain and arthritic swelling. However, the molecular basis for these pharmacological properties is only partially understood. Here, we investigated the molecular target of 1-Dehydro-10-gingerdione (D10G), one of the pungent constituents of ginger, that mediates its suppression of NF-κB-regulated expression of inflammatory genes linked to toll-like receptor (TLR)-mediated innate immunity.
    METHODS AND RESULTS:
    RAW 264.7 macrophages or primary macrophages-derived from bone marrows of C57BL/6 or C3H/HeJ mice were stimulated with the TLR4 agonist LPS in the presence of 1-Dehydro-10-gingerdione. Catalytic activity of inhibitory κB (IκB) kinase β (IKKβ) was determined by a kinase assay and immunoblot analysis, and the expression of inflammatory genes by RT-PCR analysis and a promoter-dependent reporter assay. 1-Dehydro-10-gingerdione directly inhibited the catalytic activity of cell-free IKKβ. Moreover, 1-Dehydro-10-gingerdione irreversibly inhibited cytoplasmic IKKβ-catalysed IκBα phosphorylation in macrophages activated by TLR agonists or TNF-α, and also IKKβ vector-elicited NF-κB transcriptional activity in these cells. These effects of 1-Dehydro-10-gingerdione were abolished by substitution of the Cys(179) with Ala in the activation loop of IKKβ, indicating a direct interacting site of 1-Dehydro-10-gingerdione. This mechanism was shown to mediate 1-Dehydro-10-gingerdione-induced disruption of NF-κB activation in LPS-stimulated macrophages and the suppression of NF-κB-regulated gene expression of inducible NOS, COX-2 and IL-6.
    CONCLUSIONS:
    This study demonstrates that IKKβ is a molecular target of 1-Dehydro-10-gingerdione involved in the suppression of NF-κB-regulated gene expression in LPS-activated macrophages; this suggests 1-Dehydro-10-gingerdione has therapeutic potential in NF-κB-associated inflammation and autoimmune disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.886 mL 14.43 mL 28.86 mL 57.7201 mL 72.1501 mL
    5 mM 0.5772 mL 2.886 mL 5.772 mL 11.544 mL 14.43 mL
    10 mM 0.2886 mL 1.443 mL 2.886 mL 5.772 mL 7.215 mL
    50 mM 0.0577 mL 0.2886 mL 0.5772 mL 1.1544 mL 1.443 mL
    100 mM 0.0289 mL 0.1443 mL 0.2886 mL 0.5772 mL 0.7215 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二乙酰氧基-4-姜二醇; Diacetoxy-4-gingerdiol CFN92373 863780-88-5 C19H28O6 = 352.4 5mg QQ客服：2056216494
    甲基 二乙酰氧基-6-姜二醇; Methyl diacetoxy-6-gingerdiol CFN92301 863780-90-9 C22H34O6 = 394.5 5mg QQ客服：1457312923
    1-脱氢-6-姜酮; 1-Dehydro-6-gingerdione CFN92298 76060-35-0 C17H22O4 = 290.4 10mg QQ客服：2056216494
    6-姜烯酚; 6-Shogaol CFN99531 555-66-8 C17H24O3 = 276.37 20mg QQ客服：1413575084
    二乙酰氧基-6-姜二醇; Diacetoxy-6-gingerdiol CFN92375 143615-75-2 C21H32O6 = 380.5 5mg QQ客服：215959384
    二氢非洲豆蔻醇; Dihydroparadol CFN91532 143111-84-6 C17H28O3 = 280.4 10mg QQ客服：1457312923
    非洲豆蔻醇; Paradol CFN91045 27113-22-0 C17H26O3 = 278.39 10mg QQ客服：1457312923
    (E)-[6]-去氢非洲豆蔻醇; (E)-[6]-Dehydroparadol CFN91531 878006-06-5 C17H24O3 = 276.4 5mg QQ客服：215959384
    8-姜烯酚; 8-Shogaol CFN92299 36700-45-5 C19H28O3 = 304.4 20mg QQ客服：1413575084
    10-姜烯酚; 10-Shogaol CFN92300 36752-54-2 C21H32O3 = 332.5 20mg QQ客服：1457312923

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

    联系方式


    电机：027-84237783
    传真：027-84254680
    在线QQ: 1413575084
    E-Mail：manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。