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  • 3-O-Acetyl-16 alpha-hydroxytrametenolic acid

    3-O-Acetyl-16 alpha-hydroxytrametenolic acid

    3-O-Acetyl-16 alpha-hydroxytrametenolic acid
    产品编号 CFN90804
    CAS编号 168293-13-8
    分子式 = 分子量 C32H50O5 = 514.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The sclerotium of Poria cocos(Schw.)Wolf
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 1mg QQ客服:215959384
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 5mg QQ客服:215959384
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 10mg QQ客服:215959384
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Maryland School of Medicine (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Bulletin of Health Research2016, 44(4):279-286
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Molecules.2021, 26(12):3652.
  • Pharmaceutics.2022, 14(12):2765.
  • Pharmaceutics.2021, 13(7):1028.
  • Molecules.2022, 27(2):451.
  • National Academy Science Letters2023, s40009.
  • J Ethnopharmacol.2022, 282:114574.
  • Food Chem.2017, 221:1135-1144
  • Toxicological Research2020, doi: 10.1007.
  • Nutrients.2023, 15(3):753.
  • J Ethnopharmacol.2023, 321:117501.
  • Food Chem.2019, 274:345-350
  • Cancer Manag Res.2019, 11:483-500
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Int J Mol Sci.2022, 23(20):12516.
  • Univerzita Karlova2022, 228192.
  • Applied Biological Chemistry 2022, 65,5(2022).
  • Anal Bioanal Chem.2023, 415(9):1641-1655.
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Front Pharmacol.2021, 12:615157.
  • bioRxiv - Biochemistry2023, 548213.
  • ...
  • 生物活性
    Description: 3-O-Acetyl-16 alpha -hydroxytrametenolic acid has inhibitory activities against AAPH-induced hemolysis of red blood cells, it shows a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. 3-O-Acetyl-16 alpha-hydroxytrametenolic acid markedly inhibited the promoting effect of 12-O-tetradecanoylphorbol-13-acetate (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse).
    Targets: Immunology & Inflammation related
    In vitro:
    Phytother Res. 2003 Feb;17(2):160-2.
    Inhibitory effects of triterpenes isolated from Hoelen on free radical-induced lysis of red blood cells.[Pubmed: 12601680 ]
    Hoelen, sclederma of Poria cocos Wolf, has long been used as a sedative and diuretic in traditional medicine. Formerly, we demonstrated that Hoelen in vitro protects red blood cells from AAPH-induced hemolysis.
    METHODS AND RESULTS:
    In this study, tests were carried out to identify the main ingredient of Hoelen that has the scavenging effect on free-radicals. Triterpene carboxylic acids isolated from the methanol extract of Hoelen, i.e. pachymic acid, polyporenic acid, 3-epidehydrotumulosic acid, 3beta-hydroxylanosta-7,9(11), 24-trien-21-oic acid and 3-O-Acetyl-16 alpha-hydroxytrametenolic acid, were found to have inhibitory activities against AAPH-induced lysis of red blood cells.
    In vivo:
    Oncology. 1996 Sep-Oct;53(5):382-5.
    Inhibitory effects of lanostane-type triterpene acids, the components of Poria cocos, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.[Pubmed: 8784472]
    Pachymic acid, 3-O-Acetyl-16 alpha-hydroxytrametenolic acid, and poricoic acid B had been isolated from the sclerotium of Poria cocos Wolf.
    METHODS AND RESULTS:
    These compounds showed a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. At 0.2 mumol/mouse, these compounds markedly inhibited the promoting effect of 12-O-tetradecanoylphorbol-13-acetate (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9425 mL 9.7125 mL 19.425 mL 38.85 mL 48.5625 mL
    5 mM 0.3885 mL 1.9425 mL 3.885 mL 7.77 mL 9.7125 mL
    10 mM 0.1943 mL 0.9713 mL 1.9425 mL 3.885 mL 4.8563 mL
    50 mM 0.0389 mL 0.1943 mL 0.3885 mL 0.777 mL 0.9713 mL
    100 mM 0.0194 mL 0.0971 mL 0.1943 mL 0.3885 mL 0.4856 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    松苓新酸; Dehydrotrametenolic acid CFN90577 29220-16-4 C30H46O3 = 454.69 20mg QQ客服:1413575084
    16α-羟基松苓新酸; 16alpha-Hydroxydehydrotrametenolic acid CFN90790 176390-66-2 C30H46O4 = 470.7 5mg QQ客服:1457312923
    3-O-乙酰基-16α-羟基松苓新酸; 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid CFN90791 168293-14-9 C32H48O5 = 512.7 5mg QQ客服:2159513211
    茯苓酸B; Poricoic acid B CFN95050 137551-39-4 C30H44O5 = 484.7 20mg QQ客服:2159513211
    茯苓酸G; Poricoic acid G CFN95056 415724-84-4 C30H46O5 = 486.7 5mg QQ客服:1413575084
    大戟二烯醇; Euphol CFN89516 514-47-6 C30H50O = 426.71 10mg QQ客服:2056216494
    大戟醇; Euphorbol CFN91600 566-14-3 C31H52O = 440.7 5mg QQ客服:1457312923
    羊毛甾醇; Lanosterol CFN92368 79-63-0 C30H50O = 426.7 20mg QQ客服:3257982914
    丁酰鲸鱼醇; Butyrospermol CFN92376 472-28-6 C30H50O = 426.7 5mg QQ客服:2056216494
    苦楝酮; Kulinone CFN92977 21688-61-9 C30H48O2 = 440.70 5mg QQ客服:2159513211

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