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  • 3-O-Acetyl-16 alpha-hydroxytrametenolic acid

    3-O-Acetyl-16 alpha-hydroxytrametenolic acid

    3-O-Acetyl-16 alpha-hydroxytrametenolic acid
    产品编号 CFN90804
    CAS编号 168293-13-8
    分子式 = 分子量 C32H50O5 = 514.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The sclerotium of Poria cocos(Schw.)Wolf
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 1mg QQ客服:215959384
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 5mg QQ客服:215959384
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 10mg QQ客服:215959384
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Physiologiae Plantarum2015, 37:1736
  • Arch Pharm Res.2015, 38(6):1080-9
  • J Chromatogr Sci.2015, 53(5):824-9
  • Molecules.2016, 21(6)
  • Nat Prod Sci.2016, 22(2)
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Pak J Pharm Sci.2018, 31:311-315
  • Korean J Dent Mater.2018, 45(2):139-146
  • BMB Rep.2018, 51(5):249-254
  • Nutrients.2019, 11(6):E1380
  • Chemistry of Plant Materials.2019, 129-136
  • Chinese Medicine2019, 14(1)
  • Nutr Metab (Lond).2019, 16:31
  • Chemistry of Plant Materials.2019, 215-222
  • Molecules.2019, 24(16):E2985
  • Med Sci Monit.2019, 25:9499-9508
  • Saudi Pharm J.2019, 27(1):145-153
  • Phytother Res.2019, 33(3):676-689
  • Int J Mol Med.2019, 43(6):2516-2522
  • Phytomedicine.2019, 59:152785
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Genes Genomics.2020, 10.1007
  • ...
  • 生物活性
    Description: 3-O-Acetyl-16 alpha -hydroxytrametenolic acid has inhibitory activities against AAPH-induced hemolysis of red blood cells, it shows a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. 3-O-Acetyl-16 alpha-hydroxytrametenolic acid markedly inhibited the promoting effect of 12-O-tetradecanoylphorbol-13-acetate (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse).
    Targets: Immunology & Inflammation related
    In vitro:
    Phytother Res. 2003 Feb;17(2):160-2.
    Inhibitory effects of triterpenes isolated from Hoelen on free radical-induced lysis of red blood cells.[Pubmed: 12601680 ]
    Hoelen, sclederma of Poria cocos Wolf, has long been used as a sedative and diuretic in traditional medicine. Formerly, we demonstrated that Hoelen in vitro protects red blood cells from AAPH-induced hemolysis.
    METHODS AND RESULTS:
    In this study, tests were carried out to identify the main ingredient of Hoelen that has the scavenging effect on free-radicals. Triterpene carboxylic acids isolated from the methanol extract of Hoelen, i.e. pachymic acid, polyporenic acid, 3-epidehydrotumulosic acid, 3beta-hydroxylanosta-7,9(11), 24-trien-21-oic acid and 3-O-Acetyl-16 alpha-hydroxytrametenolic acid, were found to have inhibitory activities against AAPH-induced lysis of red blood cells.
    In vivo:
    Oncology. 1996 Sep-Oct;53(5):382-5.
    Inhibitory effects of lanostane-type triterpene acids, the components of Poria cocos, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.[Pubmed: 8784472]
    Pachymic acid, 3-O-Acetyl-16 alpha-hydroxytrametenolic acid, and poricoic acid B had been isolated from the sclerotium of Poria cocos Wolf.
    METHODS AND RESULTS:
    These compounds showed a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. At 0.2 mumol/mouse, these compounds markedly inhibited the promoting effect of 12-O-tetradecanoylphorbol-13-acetate (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9425 mL 9.7125 mL 19.425 mL 38.85 mL 48.5625 mL
    5 mM 0.3885 mL 1.9425 mL 3.885 mL 7.77 mL 9.7125 mL
    10 mM 0.1943 mL 0.9713 mL 1.9425 mL 3.885 mL 4.8563 mL
    50 mM 0.0389 mL 0.1943 mL 0.3885 mL 0.777 mL 0.9713 mL
    100 mM 0.0194 mL 0.0971 mL 0.1943 mL 0.3885 mL 0.4856 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Aphagranin A ; Aphagranin A CFN96579 1318173-53-3 C33H54O6 = 546.79 5mg QQ客服:2932563308
    金钱松呋喃酸; Pseudolarifuroic acid CFN91924 130825-79-5 C30H42O4 = 466.65 5mg QQ客服:2932563308
    3-氧代甘遂-7,24-二烯-21-酸; 3-Oxotirucalla-7,24-dien-21-oic acid CFN97609 82464-35-5 C30H46O3 = 454.69 5mg QQ客服:2159513211
    苦楝萜酸甲酯; Methyl kulonate CFN92975 22611-37-6 C31H48O4 = 484.71 5mg QQ客服:2159513211
    帕克醇; Parkeol CFN92825 514-45-4 C30H50O = 426.7 5mg QQ客服:2159513211
    葫芦二烯醇; Cucurbitadienol CFN92378 35012-08-9 C30H50O = 426.7 5mg QQ客服:1413575084
    桦褐孔菌醇; Inotodiol CFN92367 35963-37-2 C30H50O2 = 442.7 5mg QQ客服:2159513211
    3beta-羟基羊毛甾-8,24-二烯-21-醛; 3beta-Hydroxylanosta-8,24-diene-21-al CFN92365 96574-03-7 C30H48O2 = 440.7 5mg QQ客服:215959384
    3β-羟基-羊毛甾-8,24-二烯-21-酸; Trametenolic acid CFN92366 24160-36-9 C30H48O3 = 456.7 5mg QQ客服:2932563308
    Tsugaric acid A; Tsugaric acid A CFN90990 174391-64-1 C32H50O4 = 498.8 5mg QQ客服:3257982914

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