3-O-乙酰基-16α-羟基松苓新酸

3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

	产品编号	CFN90791
	CAS编号	168293-14-9
	分子式 = 分子量	C₃₂H₄₈O₅ = 512.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The sclerotium of Poria cocos(Schw.) Wolf
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
3-O-乙酰基-16α-羟基松苓新酸	CFN90791	168293-14-9	1mg	QQ客服：3257982914
3-O-乙酰基-16α-羟基松苓新酸	CFN90791	168293-14-9	5mg	QQ客服：3257982914
3-O-乙酰基-16α-羟基松苓新酸	CFN90791	168293-14-9	10mg	QQ客服：3257982914
3-O-乙酰基-16α-羟基松苓新酸	CFN90791	168293-14-9	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

National Cancer Center Research Institute (Japan)

Uniwersytet Jagielloński w Krakowie (Poland)

University of South Australia (Australia)

Tohoku University (Japan)

Universidad de La Salle (Mexico)

Medizinische Universit?t Wien (Austria)

Kyung Hee University (Korea)

Korea Food Research Institute(KFRI) (Korea)

University of Medicine and Pharmacy (Romania)

Instytut Nawozów Sztucznych w Pu?awach (Poland)

Agricultural Research Organization (ARO) (Israel)

University of Oslo (Norway)

Universidade do Porto (Portugal)

Srinakharinwirot University (Thailand)

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Description:

3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells.

Targets:

NO | NOS | PGE | COX

In vitro:

Bioorg Chem. 2017 Feb;70:94-99.

Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells.[Pubmed: 27912907 ]

Poria cocos Wolf (Polyporaceae) has been used as a medicinal fungus to treat various diseases since ancient times. This study aimed to investigate the anti-inflammatory chemical constituents of the sclerotia of P. cocos.
METHODS AND RESULTS:
Based on bioassay-guided fractionation using lipopolysaccharide (LPS)-stimulated Raw264.7 cells, chemical investigation of the EtOH extract of the sclerotia of P. cocos resulted in the isolation and identification of eight compounds including six triterpenoids, namely poricoic acid A (1), 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid(2), polyporenic acid C (3), 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid (4), trametenolic acid (5), and dehydroeburicoic acid (6), as well as (-)-pinoresinol (7) and protocatechualdehyde (8). The structures of the isolated compounds were determined by spectroscopic analysis, including 1H and 13C NMR spectra, and LC/MS analysis. The anti-inflammatory activities of the isolates were evaluated by estimating their effect on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated Raw264.7 as well as on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Compounds 1-5 inhibited NO production and iNOS expression in LPS-stimulated Raw264.7 cells. Among them, compound 1 exerted the highest anti-inhibitory activity and reduced PGE2 levels via downregulation of COX-2 protein expression.
CONCLUSIONS:
The findings of this study provide experimental evidence that the sclerotia of P. cocos are a potential source of natural anti-inflammatory agents for use in pharmaceuticals and functional foods. Furthermore, the most active compound 1, seco-lanostane triterpenoid, could be a promising lead compound for the development of novel anti-inflammatory agents.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
大戟二烯醇; Euphol	CFN89516	514-47-6	C₃₀H₅₀O = 426.71	10mg	QQ客服：3257982914
大戟醇; Euphorbol	CFN91600	566-14-3	C₃₁H₅₂O = 440.7	5mg	QQ客服：1413575084
羊毛甾醇; Lanosterol	CFN92368	79-63-0	C₃₀H₅₀O = 426.7	20mg	QQ客服：1413575084
丁酰鲸鱼醇; Butyrospermol	CFN92376	472-28-6	C₃₀H₅₀O = 426.7	5mg	QQ客服：1457312923
苦楝酮; Kulinone	CFN92977	21688-61-9	C₃₀H₄₈O₂ = 440.70	5mg	QQ客服：2056216494
Aphagranin A ; Aphagranin A	CFN96579	1318173-53-3	C₃₃H₅₄O₆ = 546.79	5mg	QQ客服：3257982914
金钱松呋喃酸; Pseudolarifuroic acid	CFN91924	130825-79-5	C₃₀H₄₂O₄ = 466.65	5mg	QQ客服：2159513211
3-氧代甘遂-7,24-二烯-21-酸; 3-Oxotirucalla-7,24-dien-21-oic acid	CFN97609	82464-35-5	C₃₀H₄₆O₃ = 454.69	5mg	QQ客服：2159513211
苦楝萜酸甲酯; Methyl kulonate	CFN92975	22611-37-6	C₃₁H₄₈O₄ = 484.71	5mg	QQ客服：1413575084
帕克醇; Parkeol	CFN92825	514-45-4	C₃₀H₅₀O = 426.7	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9505 mL	9.7523 mL	19.5046 mL	39.0092 mL	48.7615 mL
5 mM	0.3901 mL	1.9505 mL	3.9009 mL	7.8018 mL	9.7523 mL
10 mM	0.195 mL	0.9752 mL	1.9505 mL	3.9009 mL	4.8761 mL
50 mM	0.039 mL	0.195 mL	0.3901 mL	0.7802 mL	0.9752 mL
100 mM	0.0195 mL	0.0975 mL	0.195 mL	0.3901 mL	0.4876 mL