乙酰基-11-酮基-beta-乳香酸

3-O-Acetyl-11-keto-beta-boswellic acid

	产品编号	CFN90531
	CAS编号	67416-61-9
	分子式 = 分子量	C₃₂H₄₈O₅ = 512.72
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Boswellia carterii Birdw.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
乙酰基-11-酮基-beta-乳香酸	CFN90531	67416-61-9	10mg	QQ客服：3257982914
乙酰基-11-酮基-beta-乳香酸	CFN90531	67416-61-9	20mg	QQ客服：3257982914
乙酰基-11-酮基-beta-乳香酸	CFN90531	67416-61-9	50mg	QQ客服：3257982914
乙酰基-11-酮基-beta-乳香酸	CFN90531	67416-61-9	100mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Instituto de Investigaciones Agropecuarias (Chile)

Chinese University of Hong Kong (China)

Macau University of Science and Technology (China)

Aveiro University (Portugal)

University of Ioannina (Greece)

Tohoku University (Japan)

University of Leipzig (Germany)

Heidelberg University (Germany)

Sanford Burnham Medical Research Institute (USA)

University of Vigo (Spain)

Shanghai Institute of Organic Chemistry (China)

University of Mysore (India)

John Innes Centre (United Kingdom)

Universidad de La Salle (Mexico)

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Description:

3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(50) of 1.5 m muM.

In vitro:

Toxicol Mech Methods. 2006;16(4):199-226.

Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R)).[Pubmed: 20021046]

The novel anti-inflammatory properties of the gum resin derived from Boswellia serrata, also known as Salai guggal in Ayurvedic medicine, are well recognized and highly recommended for human consumption. The active constituents of the gum resin are boswellic acids (BAs). Among the BAs, 3-O-Acetyl-11-keto-beta-boswellic acid potently inhibits 5-lipoxygenase product formation with an IC(50) of 1.5 m muM.
CONCLUSIONS:
We developed a novel Boswellia serrata extract (5-Loxin(R)) enriched with 30% 3-O-Acetyl-11-keto-beta-boswellic acid (US Patent 2004/0073060A1).

Biomed Chromatogr. 2014 Oct;28(10):1402-8.

Comparative pharmacokinetic study of two boswellic acids in normal and arthritic rat plasma after oral administration of Boswellia serrata extract or Huo Luo Xiao Ling Dan by LC-MS.[Pubmed: 24806456]

11-keto-β-boswellic acid and 3-O-Acetyl-11-keto-beta-boswellic acid following oral administration of HLXLD or Boswellia serrata extract alone in normal and arthritic rats.
METHODS AND RESULTS:
An LC-MS method was developed and validated for the determination of 11-keto-β-boswellic acid and 3-O-Acetyl-11-keto-beta-boswellic acid in the comparative pharmacokinetic study. The results showed that there were significant differences in pharmacokinetic parameters between normal and arthritic groups. Interestingly, the absorptions of two boswellic acids were significantly higher in HLXLD than Boswellia serrata extract alone, indicating the synergistic effect of other herbal ingredients in HLXLD.
CONCLUSIONS:
This comparative pharmacokinetic study provided direct evidence supporting the notion that the efficacy of a complex mixture such as HLXLD is better than that of single components in treating human diseases.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3-O-乙酰基 9,11-脱氢 β-乳香酸; 3-O-Acetyl 9,11-dehydro beta-boswellic acid	CFN70260	122651-20-1	C₃₂H₄₈O₄ = 496.7	5mg	QQ客服：1413575084
栎樱酸; Roburic acid	CFN98562	6812-81-3	C₃₀H₄₈O₂ = 440.71	20mg	QQ客服：2056216494
野甘草酸; Dulcioic acid	CFN97681	78516-69-5	C₃₀H₄₈O₃ = 456.71	5mg	QQ客服：2159513211
Triptocallic acid A; Triptocallic acid A	CFN99881	190906-61-7	C₃₀H₄₈O₄ = 472.7	5mg	QQ客服：2056216494
22-羟基-3-氧代乌苏-12-烯-30-酸; 22-Hydroxy-3-oxo-12-ursen-30-oic acid	CFN99821	173991-81-6	C₃₀H₄₆O₄ = 470.7	5mg	QQ客服：3257982914
beta-乳香酸; Beta-boswellic acid	CFN90221	631-69-6	C₃₀H₄₈O₃ = 456.70	20mg	QQ客服：1413575084
3-乙酰基-beta-乳香酸; 3-O-Acetyl-beta-boswellic acid	CFN90530	5968-70-7	C₃₂H₅₀O₄ = 498.74	10mg	QQ客服：2159513211
11-酮基-beta-乳香酸; 11-Keto-beta-boswellic acid	CFN90152	17019-92-0	C₃₀H₄₆O₄ = 470.68	20mg	QQ客服：3257982914
乙酰基-11-酮基-beta-乳香酸; 3-O-Acetyl-11-keto-beta-boswellic acid	CFN90531	67416-61-9	C₃₂H₄₈O₅ = 512.72	20mg	QQ客服：1413575084
9,11-去氢-beta-乳香酸; 9,11-Dehydro-beta-boswellic acid	CFN95335	471-65-8	C₃₀H₄₆O₃ = 454.7	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9504 mL	9.7519 mL	19.5038 mL	39.0076 mL	48.7596 mL
5 mM	0.3901 mL	1.9504 mL	3.9008 mL	7.8015 mL	9.7519 mL
10 mM	0.195 mL	0.9752 mL	1.9504 mL	3.9008 mL	4.876 mL
50 mM	0.039 mL	0.195 mL	0.3901 mL	0.7802 mL	0.9752 mL
100 mM	0.0195 mL	0.0975 mL	0.195 mL	0.3901 mL	0.4876 mL