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  • 11-酮基-beta-乳香酸

    11-Keto-beta-boswellic acid

    11-酮基-beta-乳香酸
    产品编号 CFN90152
    CAS编号 17019-92-0
    分子式 = 分子量 C30H46O4 = 470.68
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Boswellia carterii Birdw.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    11-酮基-beta-乳香酸 CFN90152 17019-92-0 10mg QQ客服:3257982914
    11-酮基-beta-乳香酸 CFN90152 17019-92-0 20mg QQ客服:3257982914
    11-酮基-beta-乳香酸 CFN90152 17019-92-0 50mg QQ客服:3257982914
    11-酮基-beta-乳香酸 CFN90152 17019-92-0 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Pennsylvania State University (USA)
  • Universit?t Basel (Switzerland)
  • University of Leipzig (Germany)
  • China Medical University (Taiwan)
  • University of Sao Paulo (Brazil)
  • Aveiro University (Portugal)
  • Seoul National University (Korea)
  • Universidade Federal de Santa Catarina (Brazil)
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  • The University of Newcastle (Australia)
  • Uniwersytet Gdański (Poland)
  • Monash University Malaysia (Malaysia)
  • Aarhus University (Denmark)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Environ Toxicol.2020, doi: 10.1002
  • Drug Chem Toxicol.2020, 1-14.
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Int J Mol Sci.2023, 24(8):7442.
  • bioRxiv2021, 462065.
  • J Pharm Biomed Anal.2018, 151:32-41
  • Curr Issues Mol Biol.2023, ;45(2):1601-1612.
  • J of Apicultural Research2020, 10.1080
  • Antioxidants (Basel).2022, 11(1):171.
  • Nanjing University of Chinese Medicine2022, 345930.
  • J Food Sci.2021, 86(9):3810-3823.
  • Turk J Med Sci.2023 53: 1312-1320.
  • Nutrients.2021, 13(1):254.
  • Phytomedicine.2021, 2(82):153452
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • Phytomedicine.2022, 99:154025.
  • Bioorg Med Chem.2020, 28(12):115553.
  • J Chromatogr A.2022, 1685:463640.
  • Phytomedicine.2022, 100:154058.
  • ...
  • 生物活性
    Description: 11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenase; and it can increase the Nrf2 and HO-1 expression, which provides protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. 11-Keto-beta-boswellic acid possesses significant anti-inflammatory, and anti-tumoral activities.
    Targets: NO | PI3K | Akt | HSP (e.g. HSP90) | NF-kB | Bcl-2/Bax | Caspase | PARP | Nrf2 | HO-1 | PARP | LOX | COX | TNF-α | 5-LOX
    In vitro:
    Phytochemistry. 2013 Dec;96:330-6.
    Biotransformation of 11-keto-β-boswellic acid by Cunninghamella blakesleana.[Pubmed: 23962801]
    11-Keto-beta-boswellic acid (KBA), as one of the active constituents in the gum resin of Boswellia serrata, possesses significant biological activities including anti-inflammatory activity. However, its extensive metabolism and low polarity has limited the systemic availability of 11-Keto-beta-boswellic acid. The present research was aimed to obtain and explore the various possible derivatives of 11-Keto-beta-boswellic acid through biotransformation by Cunninghamella blakesleana AS 3.970.
    METHODS AND RESULTS:
    A total of ten transformed compounds were isolated and purified, and their chemical structures were characterized as 7β-hydroxy-11-keto-β-boswellic acid; 7β, 15α-dihydroxy-11-keto-β-boswellic acid ; 7β, 16β-dihydroxy-11-keto-β-boswellic acid; 7β, 16α-dihydroxy-11-keto-β-boswellic acid; 7β, 22β-dihydroxy-11-keto-β-boswellic acid; 7β, 21β-dihydroxy-11-keto-β-boswellic acid; 7β, 20β-dihydroxy-11-keto-β-boswellic acid; 7β, 30-dihydroxy-11-keto-β-boswellic acid; 3α, 7β-dihydroxy-11-oxours-12-ene-24, 30-dioic acid and 3α, 7β-dihydroxy-30-(2-hydroxypropanoyloxy)-11-oxours-12-en-24-oic acid by various spectroscopic methods. The biotransformation processes include hydroxylation, oxidation and esterification. Primary structure-activity relationships (SAR) of inhibitory effects on NO production in RAW 264.7 macrophage cells are discussed.
    Eur J Med Chem. 2015 Jul 15;100:98-105.
    11-Keto-boswellic acid derived amides and monodesmosidic saponins induce apoptosis in breast and cervical cancers cells.[Pubmed: 26073487 ]
    Beta-boswellic acids are considered the main bioactive components of frankincense. Their potential to act as cytotoxic agents, as well as that of their derivatives remained unexploited so far.
    METHODS AND RESULTS:
    In this study we were able to prepare derivatives of 11-keto-β-boswellic acid (KBA) that showed lower IC50 values as determined by a sulphorhodamine B (SRB) assay using several different human tumour cell lines. Monodesmosidic saponins of KBA are as cytotoxic as 3-acetyl-KBA. The presence of a free hydroxyl group at position C-3 seems to lower cytotoxicity while the presence of an amide function at C-24 improves cytotoxicity. The most active compound of this series gave IC50 values as low as 4.5 μM.
    CONCLUSIONS:
    Cell death proceeded mainly via apoptosis.
    In vivo:
    Mol Neurobiol. 2015 Dec;52(3):1430-1439.
    Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia-Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism.[Pubmed: 25452227]
    Oxidative stress is well known to play a pivotal role in cerebral ischemia-reperfusion injury. The nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway has been considered a potential target for neuroprotection in stroke. 11-Keto-beta-boswellic acid(KBA) is a triterpenoid compound from extracts of Boswellia serrata. The aim of the present study was to determine whether KBA, a novel Nrf2 activator, can protect against cerebral ischemic injury.
    METHODS AND RESULTS:
    Middle cerebral artery occlusion (MCAO) was operated on male Sprague-Dawley rats. KBA (25 mg/kg) applied 1 h after reperfusion significantly reduced infarct volumes and apoptotic cells as well as increased neurologic scores at 48 h after reperfusion. Meanwhile, posttreatment with KBA significantly decreased malondialdehyde (MDA) levels, restored the superoxide dismutase (SOD) activity, and increased the protein Nrf2 and HO-1 expression in brain tissues. In primary cultured astrocytes, KBA increased the Nrf2 and HO-1 expression, which provided protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. But knockdown of Nrf2 or HO-1 attenuated the protective effect of KBA.
    CONCLUSIONS:
    In conclusion, these findings provide evidence that the neuroprotection of KBA against oxidative stress-induced ischemic injury involves the Nrf2/HO-1 pathway.
    BMC Vet Res . 2019 Aug 1;15(1):270.
    Measurement of 3-acetyl-11-keto-beta-boswellic acid and 11-keto-beta-boswellic acid in Boswellia serrata Supplements Administered to Dogs[Pubmed: 31370899]
    Abstract Background: Osteoarthritis is a common canine disease frequently treated with nutritional supplements that often lack independent verification of ingredients, active ingredient concentration, efficacy, or safety. Human supplements containing Boswellia serrata extracts (BSE) with high concentrations of active constituents 3-acetyl-11-keto-β-boswellic acid (AKBA) and 11-keto-β-boswellic acid (KBA) are bioavailable, safe, and efficacious in the alleviation of symptoms of naturally occurring osteoarthritis in people. Thus, oral AKBA and/or KBA supplementation could be a promising novel therapy for dogs with osteoarthritis. The primary objective of this study was to determine the concentrations of AKBA and KBA within six human and seven canine market formulations containing BSE administered to dogs, using a derivation of the previously validated high performance liquid chromatography (HPLC) method. The secondary objective was to compare measured concentrations to label claims. Results: The mean concentrations of AKBA and KBA within the formulations tested were 42.3 mg/g AF (0.1-155.7 mg/g AF) and 5.2 mg/g AF (0-24.8 mg/g AF), respectively, with four of the formulations containing an undetectable amount of KBA. None of the market formulations had a label claim for KBA. For the five tested formulations with a label claim for AKBA, the mean percentage of detected AKBA was 173% of the concentration listed on the label (range: 114-224%). Formulations claiming to contain AKBA had a mean AKBA concentration of 98.2 mg/g AF, significantly higher than formulations claiming only to contain BSE (7.4 mg/g AF; p = 0.01). Conclusions: This study demonstrated a large variation of boswellic acid concentrations in market formulations claiming to contain BSE, with products claiming to contain AKBA containing higher concentrations of AKBA than other products. There was also a large variation in, and overall high, percent difference between label claims and measured concentrations of AKBA. All products met or exceeded label claims. However, differences between label amounts and detected concentrations confirm the need for independent laboratories to quantify concentrations of active ingredients in supplements containing BSE. This would be necessary prior to the use of these formulations in the research or clinical setting. Keywords: Boswellia serrata; Boswellic acids; Canine osteoarthritis; Chromatography; Frankincense; Nutraceutical.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1246 mL 10.6229 mL 21.2459 mL 42.4917 mL 53.1146 mL
    5 mM 0.4249 mL 2.1246 mL 4.2492 mL 8.4983 mL 10.6229 mL
    10 mM 0.2125 mL 1.0623 mL 2.1246 mL 4.2492 mL 5.3115 mL
    50 mM 0.0425 mL 0.2125 mL 0.4249 mL 0.8498 mL 1.0623 mL
    100 mM 0.0212 mL 0.1062 mL 0.2125 mL 0.4249 mL 0.5311 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-O-乙酰基 9,11-脱氢 β-乳香酸; 3-O-Acetyl 9,11-dehydro beta-boswellic acid CFN70260 122651-20-1 C32H48O4 = 496.7 5mg QQ客服:2159513211
    栎樱酸; Roburic acid CFN98562 6812-81-3 C30H48O2 = 440.71 20mg QQ客服:2159513211
    野甘草酸; Dulcioic acid CFN97681 78516-69-5 C30H48O3 = 456.71 5mg QQ客服:3257982914
    Triptocallic acid A; Triptocallic acid A CFN99881 190906-61-7 C30H48O4 = 472.7 5mg QQ客服:1413575084
    22-羟基-3-氧代乌苏-12-烯-30-酸; 22-Hydroxy-3-oxo-12-ursen-30-oic acid CFN99821 173991-81-6 C30H46O4 = 470.7 5mg QQ客服:3257982914
    beta-乳香酸; Beta-boswellic acid CFN90221 631-69-6 C30H48O3 = 456.70 20mg QQ客服:3257982914
    3-乙酰基-beta-乳香酸; 3-O-Acetyl-beta-boswellic acid CFN90530 5968-70-7 C32H50O4 = 498.74 10mg QQ客服:1457312923
    11-酮基-beta-乳香酸; 11-Keto-beta-boswellic acid CFN90152 17019-92-0 C30H46O4 = 470.68 20mg QQ客服:2159513211
    乙酰基-11-酮基-beta-乳香酸; 3-O-Acetyl-11-keto-beta-boswellic acid CFN90531 67416-61-9 C32H48O5 = 512.72 20mg QQ客服:215959384
    9,11-去氢-beta-乳香酸; 9,11-Dehydro-beta-boswellic acid CFN95335 471-65-8 C30H46O3 = 454.7 5mg QQ客服:2056216494

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